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Demos Trials

Small Molecule Drug Discovery powered by ChemDraw™

Signals One™️, with the power of ChemDraw built in, helps research teams move their small-molecule portfolio from idea to clinical candidate—from design to decision.

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Signals Notebook - ChemDraw Integration Showcase

In this short interactive demo, see small molecule research 
in action: 

  • Run a synthetic chemistry experiment
  • Attach experimental data
  • Search chemical structures
  • Create reusable templates
  • Repurpose existing experiments
Explore Now
    Design

    Design small molecules with the industry standard for chemical drawings

    Whether you’re creating chemical libraries, exploring SAR, developing PROTACs, macrocycles, molecular glues, 
    or designing payloads for multimodal therapeutics, you can 
    create your molecules in Signals Notebook with integrated 
    ChemDraw™—the leading chemical drawing solution for over 40 years, refine your design with Signals One, and collaborate easily with Signals Synergy:

    • Visualize and modify your molecular layouts effortlessly with the power and familiarity of ChemDraw
    • Collaborate with external partners via Signals Synergy and share insights across teams with traceable design support  
    • Optimize design properties early with AI-enabled predictive modeling in Signals One

    Go from initial idea to high-confidence candidate with connected, chemistry-first design tools.

    Explore ChemDraw-powered design   

    Make

    Capture every step from synthesis to scale

    Whether creating novel compounds or optimizing the synthesis process, Signals Notebook helps teams document and track reaction conditions, reagent sources, and inventory.

    • Record reaction conditions, reagents, yields, and batches in Signals Notebook
    • Manage inventory and prevent repeated work with centralized inventory management
    • Collaborate with CDMOs and other external partners using Signals Synergy to support and scale small-molecule synthesis projects
    • Keep track of each molecule and prevent costly manual audits by linking downstream characterization to each molecule in Signals Notebook

    Maximize efficiency, scalability, and repeatability with clear, collaborative, and centralized documentation and data.

    See how Signals Notebook + Synergy supports internal and external synthesis and inventory tracking 

    Test

    Characterize with confidence by linking experimental data to each molecule

    Small-molecule therapeutics need to be effective, safe, stable, and bioavailable. Signals One helps unify diverse types of experimental data into one coherent view.

    • Customizable workflows supporting multiple levels of screening and data capture, from high-throughput screening to toxicology and PK/PD testing
    • Link screening data directly to individual compounds and batches in Signals One for full traceability
    • Visualize comparative results with native analytics including curve fitting, clustering, and PCA

    Streamline data capture, comparison, and interpretation across your small molecule screening pipeline with Signals One.

    Discover how Signals One supports small molecule screening

    Decide

    Advance the right candidates with multiparameter confidence

    Identify lead candidates and prioritize next steps with decision support that enables fast, evidence-based go/no-go decisions based on multiparameter optimization and structure-activity relationship (SAR) insights, including properties such as potency, selectivity, solubility, permeability, protein binding, clearance and tolerability.

    • Use Spotfire analytics in Signals One to compare compound profiles across key attributes
      Compare compounds across multiple attributes with multiparameter optimization (MPO) and insights from SAR to find “Goldilocks” candidates
    • Run automated PCA and clustering to identify trends across assays and candidates
    • Make transparent go/no-go decisions faster with all your data in one place 

    Turn your molecular data into momentum with clear, confident decisions.

    Explore MPO for small molecule screening in Signals One 

    Drug Discovery for Every Modality

    Signals is the cloud software suite that accelerates drug discovery for every modality, enabling your team to confidently advance from concept to candidate.
     

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