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What's New

Explore recent and historical product updates for Revvity Signals' Cloud Native SaaS Software 

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What’s New

The latest release of Signals introduces significant enhancements to the ChemDraw+ application.  HELM editing capabilities have been substantially expanded, now featuring the ability to create complementary strands with hydrogen bonding with several different new tools. We've improved the user drawing experience by incorporating a new drawing tool and access to symbols commonly used in chemical names and reactions. Finally, several bug fixes have been extended with this release. 

The following improvements are available for users of Signals ChemDraw. Certain features may only be available with enablement by an administrator.

ChemDraw+

-    Selection of attachment points between monomers to create biopolymer crosslinks
-    Complementary strands generated from text tab now contain hydrogen bonds
-    Generate complementary strand tool 
-    HELM Auto-pair tool
-    Show 3' and 5' ends of oligonucleotides
-    Chemical Symbols
-    Join tool

 

ChemDraw+

Selection of attachment points between monomers to create biopolymer crosslinks 

The creation of biopolymer crosslinks between monomers with multiple possible attachment points is now supported. When creating a crosslink, the monomers will now expand, allowing users to select specific attachment points to make the connection. After making the selection, users can finalize the process by selecting "Connect," and the monomers will be successfully crosslinked. 

Complementary strands generated from text tab now contain hydrogen bonds

Complementary strands of RNA or DNA that are created from the text tab of the HELM editor are now created with hydrogen bonds automatically mapped between the strands. The hydrogen bonds are placed according to Watson-Crick base pairing. Hydrogen bond pairing information is also now supported in ChemDraw when inserting HELM strings or pasting them on the canvas. Additionally, when generating a HELM string for a sequence containing hydrogen bonds, the resulting HELM string will now contain the pairing details.

Generate complementary strand tool

Complementary strands of oligonucleotides can now be generated from a selected oligonucleotide on the ChemDraw canvas.  This new tool is available on the right-hand context toolbar allows users to generate a complementary strand when an oligonucleotide is selected. When this new tool is used, a complementary strand will be generated with hydrogen bonds automatically mapped between the strands. The hydrogen bonds are placed according to Watson-Crick base pairing. For sequences containing custom monomers, the complement will be based on the natural monomer equivalents of the selected sequence.

HELM Auto-pair tool

Complementary strands of oligonucleotides can now be selected and automatically paired in the new ChemDraw editor. When paired, hydrogen bonds will be placed between the strands according to Watson-Crick base pairing, with maximum overlap in complementarity between the strands. For sequences containing custom monomers, the hydrogen bonding will be placed according to Watson-Crick base pairings based on the natural monomer analogs. The auto-pair tool will appear on the right-hand context toolbar when two oligonucleotide sequences are selected.

Show 3' and 5' ends of oligonucleotides

A new option has been added to the Biopolymer section of the Properties panel in the new ChemDraw editor which allows users to display the 3' and 5' ends of an oligonucleotide on the canvas. When an oligonucleotide is selected, users can choose to show or hide the label by selecting or unselecting this option.

Chemical Symbols

Common symbols used in chemical names and reaction conditions can now be added to a ChemDraw text element in the new ChemDraw editor using the new Chemical Symbols tool. This tool will be available on the right-hand context toolbar when editing in a text element on the ChemDraw canvas.

Join tool

A new join tool is now available on the right-hand context toolbar of the new ChemDraw editor. When used, the join tool allows users to combine structures on the ChemDraw canvas by merging two or more selected atoms into a single atom.


What’s New

The latest release of Signals introduces enhancements to the ChemDraw+ application.  Structure based searching capabilities have been added to allow users to filter and search for drawings containing chemical structures. Additionally new capabilities and enhancements have been made to the HELM drawing capabilities. Finally, several bug fixes have been extended with this release.

The following improvements are available for users of Signals ChemDraw. Certain features may only be available with enablement by an administrator.

ChemDraw+

-    Structure based searching
-    Sharing of Drawings
-    HELM in-line annotation support for monomers and polymers 
-    Biopolymer connections now appear curved instead of sharp corners


 

ChemDraw+

Structure based searching

New filtering and search capabilities have been added to the application for filtering and searching drawings based on chemical structures. Available as a button next to the text search field in the list views, the ‘Draw…’ button opens a structure editor. 

After drawing a structure, users can select from substructure, similarity, full, and exact search options. Selecting 'Search' will then initiate the search filter.  

After completing a structure search, the 'Draw' button transforms into an 'Edit' button. Selecting this button allows for previewing the structure, making changes to it, or removing it from the search filter. Structure searches can be combined with text-based searches to refine results even further.

Sharing of Drawings

Users can now share Drawings with other users or groups in ChemDraw+ from within a drawing or from the Actions menu in a Drawings list view.

During the sharing process, you can specify Read, Write, or Full access permissions. Once shared, these permissions can be modified or revoked as needed.
 



Recipients will receive an automatic notification when a drawing is shared with them.

HELM in-line annotation support for monomers and polymers

Annotation capabilities are now available for monomers and biopolymers through the properties panel. When a monomer or biopolymer is selected, users can access a new Annotation field in the Monomer or Biopolymer section, allowing them to add simple text and descriptions to specific parts of their sequence. For annotated monomers, a badge appears on the graphic to indicate the presence of an annotation which is also viewable in the hover-over preview. 

Biopolymer annotations are directly added to the ChemDraw canvas, appearing centered above or below the sequence. These annotations can be imported from HELM strings and are added as in-line annotations to the HELM string when generated. 

Biopolymer connections now appear curved instead of sharp corners

Biopolymer visualization has been refined in this release with the introduction of curved crosslinks and connections, replacing the previous sharp-cornered design. This enhancement significantly improves the visual clarity of complex structures, allowing users to easily distinguish between crosslinks and chemical linkages between monomers.