Revvity Signals

What's New

We are delighted to release our new version of Signals, 25.5. This release brings enhancements in Signals Synergy, our SAR and Decisioning capabilities, Samples, Materials Libraries and Inventory, and to Admin Defined Tables and Variation Tables amongst others. We have new beta capabilities for SAR and decisioning and an AI based capability to extract text from images. Finally, we have also fixed a number of small bugs.

This release of Signals brings updates to the horizontal view, and management of materials, in Variation tables. We have extended import and export flows to and from Signals Synergy, including a beta capability in publishing table data to Inventa. We have redesigned Order and Internal Request Tables in Inventory, extended the material lineage capability and extended our extraction coverage for the ELN archive. We have extended the utility of autotext, and added calculated product equivalents in the stoichiometry tables. Finally, we have also fixed a number of small bugs.

The following improvements are available for users, administrators and developers on the Signals platform. Certain features may only be available with appropriate licensing and/or with enablement by an administrator.

Fundamentals
–Spotfire Connector Oracle available
–Addition of Plates to Parallel Experiments
–Automatic fill of hierarchical attribute child value if it is the only child
AI
–Text Extraction from Images (beta)
SAR & Decisioning
–HELM rendering supports ChemDraw and custom coloring schemes
–Nanobody Structure Prediction Data Function
–Embed GenBank Data Function
–Mapping useability enhancements in Publish Results to Data Factory app (beta)
–Downloadable report for successful publications (beta)
Synergy
–Create Work Order privilege
–Select default Synergy Experiment Template for a Work Order Template
–Include Reference Table configuration in a Work Order Template
–Admin-defined fields for Reference Tables
–Add Designs to Work Order Reference Tables from multiple Ideas
–Customize Design ID sequence
–Sponsor users Quick Add Designs to Chemical Drawings in Experiments, ADOs, and Synergy Experiments
–Expanded Designs Statuses for Design synthesis tracking and Approve Designs for Synthesis privilege – available to all systems
–Bulk Design status update from Designs Smart Folder Data Grid view – available to all systems
–Kanban board view in Designs Smart Folder for Designs synthesis tracking – available to all system
Admin Defined Tables & Variation Tables
– CASE function
– Multiline entry in equation editor
– Improvements to the Horizontal Summary View in Variation Tables
– Publish Variation Tables to Inventa available to all systems
Samples
– Autoscaling of units for Sample Moles calculation
– Significant figure handling improvements in Sample calculations
Inventory
– New labels
– Requests support Internal Request workflow
– System Supplier List available in new container creation workflow (beta)
– Add Material Library properties to container labels
Materials
– Updates to the Materials Table material selection
– Change the batch/lot of a selected material
– Calculated properties for DNA and RNA materials
– Bulk import with multipart GenBank and FASTA files
– Disregard Order in Materials Bulk Import
Administration
– ChemDraw aromatic display preferences are respected in Inventa
Integrations & APIs
– API update to allow chemical drawing import via HELM
– API for fetching bulk import success reports
– API for fetching Worksheet field definitions
– APIs for fetching and creating CRO users
– External Actions can be hidden from CROs

We also fixed several small bugs in this release. Details of the enhancements are described below.

The following OnDemand videos for Signals Notebook End Users are now available

Materials Table: Register and Manage Materials within an Experiment

System administrators of Signals Synergy should be aware that there is a new privilege called Add Work Orders that is now required to create Work Orders. Previously, no privilege was required to create Work Orders. For users to continue creating Work Orders, you must grant them this privilege via a role.

Data Factory administrators should be aware that job-service/postJobserviceLoad primary API is now asynchronous and will immediately respond with a 202 and the string “accepted”. It will no longer return the job’s information.

Data Factory administrators should be aware that the DELETE /information-design-service/mtypes/{name} primary API now returns 409: Conflict when trying to delete a measurement type linked to an Experiment, ADO, or Table in Signals One.

Developers should note that we have changed the GET/entities endpoint to no longer allow for both “trashed” and “untrashed” items to be fetched simultaneously. The "includeOptions" will continue default to "untrashed" when no explicit parameters are specified. This change only impacts customers who are explicitly setting “includeOptions” to “trashed,untrashed” or any combination including both.

Administrators are recommended to subscribe to the channels within our support news site found at https://support.revvitysignals.com/hc/en-us/categories/360004446171-Support-News which contains more information about releases and other pertinent product information.

This content is anticipated for release on our Production E3 environments, and for Private Cloud customers on our deferred release schedule, in November 2025.

Further Details

Fundamentals

Spotfire Connector Oracle is available within Spotfire for Signals. The end user must install the required driver for function in Spotfire for Signals Analyst. Data Connection information must be embedded in analysis file. Authoring, editing, and creating new is supported in Spotfire for Signals Analyst while Spotfire for Signals Online can consume existing.

Users are now able to add the standard Plate element in Parallel Experiments using the Add Content dropdown. When populating the plates using Autofill, the user now can populate that plate with samples from the Sample Summary table.

In a click reduction effort, child fields in a Parent/Child Hierarchical Attribute pair will automatically fill if the user only has access to a single child of their selected parent. This is no way alters user access to values in the HA. Users are still able to remove any auto-filled child attributes.

SAR & Decisioning

Users can now customize HELM rendering in ChemCharts visualizations by selecting predefined ChemDraw or Pistoia styling, or by creating their own custom color and shape schemes

Users can now embed GenBank files into Inventa Analysis using the ChemCharts 'Embed GenBank Files' data function, which extracts GenBank IDs and file content from URLs in Spotfire tables

Users can leverage the new 'Nanobody Dashboard' ChemCharts data function to generate comprehensive visualizations for nanobody developability assessment, including 3D structure prediction, antibody numbering, surface area analysis, developability metrics, and sequence liability identification

Synergy

The System Admin can now control which Roles can create Work Orders using the new Add Work Orders privilege. Previously, all users with access to the Synergy App (Synergy App privilege) could create Work Orders; now, users must be granted this privilege in Signals Configuration to create Work Orders.

For commonly used workflows, several improvements have been made to reduce the number of clicks required by the Sponsor end user. First, a default Synergy Experiment template can be selected for a given Work Order Template. This allows the Sponsor end user to create a Work Order and the Draft Synergy Experiment using a single creation screen. In addition, the admin can now add a Reference Table to the Work Order Template and pre-configure the default shared properties.

Reference Table configuration also now supports admin-defined fields, in addition to the shared properties of Designs or Material Assets and Batches. Reference Table admin-defined fields can be used to convey additional information to the CRO, such as which assays to run on specific compounds or the amount and minimum purity requested for Design synthesis.

For Designs, the Design ID is now customizable by the admin in Synergy Configuration. In addition, Designs from multiple Ideas (e.g., across chemistry teams or across projects) can now be added to a Reference Table in a single Work Order.

Finally, internal users can now use the Quick Add toolbar to easily add Design structures to Chemical Drawings in Experiments, admin-defined objects, and Synergy Experiments. The Design ID will be added to the stoichiometry grid Product or Reactant Table and propagated to any subsequently created Sample(s) and then into the Originating Design on registered Material(s) from the Sample(s).

Finally, expanded Design statuses for Design synthesis tracking, Approve Designs privilege, bulk status updates, and a Kanban Board view of Designs by Status in the Designs Smart Folder are now available to all systems.

Admin Defined Tables & Variation Tables

We have added a new conditional function, CASE, to the equation editor in Admin Defined Tables and Variation Tables. The CASE statement allows the admin to define a series of up to 20 different outcomes based off of the results in a given comparison column. The first matching result is provided. The admin can define a final result should no outcomes match. This provides a more elegant alternative to nested IF statements.

We have also updated the equation editor to allow multirow editing to aid in the definition of the equations for more complex equations such as those using the CASE function above.

The Horizontal View in Variation Tables has been updated to highlight the variant, the component and the header of the column so users can easily see where they are entering values:

The publication of Variation Tables to Inventa is now available to all systems.

Samples

To conserve the behavior from calculations in the stoich grid in the Sample calculations, autoscaling of units for Sample Moles calculation have been added along with Significant figure handling improvements in Sample calculations.

Significant Figures are now applied to calculated values for Sample Yield and Moles in Samples: Moles should have the same number of Significant Figures as Amount, Sample Yield should have the same number of Significant Figures as Moles in Samples when the number of Significant Figures for Theo Moles in Products is higher, and Sample Yield should have the same number of Significant Figures as Theo Moles in Products when the number of Significant Figures for Moles in Samples is higher.

Inventory

We have added a 64 by 19 mm label:

A 47 by 30 mm label:

And a 25 by 25 mm option with 1 slot:

Requests support Internal Request workflow. Users can now use the Internal Request workflow from inside of a Request in the Task and Request workflow:

Adding an Internal Request will allow users to choose materials from the Samples, Task To Do or Materials Tables:

The Internal Request will be available from inside of the Request:

And can be seen in the Internal Request Table:

Add Material Library properties to container labels. Some properties make sense to store on the material in the Material Library. To not duplicate data, administrators can now pull the data from Material Libraries into the container label. If multiple Material Libraries have the same property to be printed on a label (ex: purity), the administrator can select the property to be added to the label from multiple Material Libraries in one slot on the label:

Materials

Updates to the Material Table materials selection. Users can now select the asset or the batch/lot to be added to a Materials Table:

Users can select the Batch/Lot or Asset option in the filter on the left to narrow the selection:

Both Assets and Assets with Batch/Lots will be added to the table:

Change the batch/lot of a selected material. If users have selected a specific batch/lot of a material, they can update the batch/lot to a different one:

If a batch/lot is not currently selected, one can be selected:

If a container has already been selected and a decrement has been entered and the user wants to update the batch/lot, a message will appear:

Calculated properties are now available for DNA and RNA material types and in the preconfigured Primers and Plasmids libraries. Molecular weight, GC content, extinction coefficient, and melting temperature are available for single-stranded and double-stranded molecules.

Multipart GenBank and FASTA files can now be bulk imported into a DNA or RNA materials library. Workflows are available to bulk import a collection of single sequence files (current capability), a single multipart GenBank or FASTA file and corresponding meta-data (via .zip folder), or a single multipart GenBank or FASTA file with fixed values (via multipart .gb or .fa file).

There is a new option that allows for the parallelization of Material import while still utilizing matching against materials already stored in SNB. It is critical to note that for uniqueness checking to occur correctly there can be NO DUPLICATE values within the file to be uploaded as these values will be parallelized for import and checked against values within the system.

Administration

The Signals Research Suite license is now renamed Signals One and can be seen in the Users pages within Signals Configuration. The bulk update user file and integrations such as APIs are unchanged.

Admins are now able to manage the chemistry autotext. Under System Settings, there is a new Chemistry Autotext option that allows the admin to select which properties available in the Stoich grid appear in the Chemistry Autotext. Admins are now able to include custom admin defined stich properties in their Chemistry Autotext.

Integrations & APIs

This update brings additional endpoints for our Synergy product. New APIs have been added to fetch and create CRO users. CRO users may be fetched by CRO using the CRO or you may fetch the CRO a user belongs to by user ID.

To create a user as member of a CRO the CRO must be specified as part of the URL parameters by CRO ID. The request body should contain the details of the CRO user.

As a reminder CRO IDs can be fetched using GET /synergy/cros.

Additionally, External Actions may now be configured by an Admin to be displayed or not to CRO users similar to External Data Sources. This is specific to each External Action and toggleable during creation or while editing an existing External Action. Existing External Actions and newly created ones will default to not display for CROs.

POST /entity/children/{filename} has been enhanced to allow for using HELM strings for creating child chemical drawings. The content-type should be specified as chemical/x-helm and send a request body containing a HELM string.

POST /materials/{libraryName}bulkImport has been enhanced. You may now specify a reportFormat via URL parameter when creating a bulkImport job: 'FAILURES_ONLY', the report only includes the materials which failed to import. This is the default value; 'DUPLICATES_AND_FAILURES', the report includes the materials which failed to import or duplicated.; 'ALL_RESULTS', the report includes the materials which imported successfully, failed to import or duplicated.

The API now allows for matching the available behavior for report generation via UI.

An API has been added to fetch the report by the jobID returned by the bulkImport request.

A new API has been added to fetch worksheet field definitions via API by a worksheets entity ID. This behaves similar to fetching ADT column definitions.

Further Details

The following capabilities are in beta and are available for users, administrators and developers on the Signals platform upon request. Please contact your account representative or our support team if you would like access to the following features.

AI

For tenants with a Signals One license, users will now be able to utilize AI to extract and search by text from uploaded Images. This includes files of JPEG, PNG, and TIFF. This will apply to newly uploaded images only. Should a user load an image similar to the one shown here they would be able to search for it using keywords from the image like DMF, DMC, etc.

SAR & Decisioning

As part of the Data Factory beta, enhancements to mapping and reporting are now available.

Data Factory Publication Reports now include downloadable summaries for successful publications, providing key metadata such as file details, project information, and publication date.

The Publish Results to Data Factory app introduces convenient mapping controls including automapping, filtering options for mapped/unmapped columns, and the ability to reset to default mapping

Inventory

System Supplier List available in new container creation workflow:

Administrators of existing systems can update the Container Type by selecting the System Supplier List to be added to the Container Type:

What's New

We are delighted to release our new version of Signals, 25.6. This release brings enhancements in audit trials, Synergy, Inventory, Variation Tables and Inventa amongst others. We have a new beta capabilities of an In Vitro Analysis object, and extended beta capabilities around publishing results to Data Factory. The beta capabilities around Internal Data Sources in Text Elements are now available to all systems. Finally, we have also fixed a number of small bugs.

Fundamentals
–Audit trail captures the initial state of content upon copying a system template, experiment, or personal template
AI
–Schema Updates to support SDK Generation
Data Workflows & Analytics
–In Vitro Analysis (beta)
SAR & Decisioning
–Internal References support in Inventa Analyses
–Integrated Summary App supports “Is Any Of” for numeric attributes
–Automapping improvements in Publish Results to Data Factory app (beta)
Synergy
–Support for Normalized Compounds in Synergy Designs and Reference Tables
–Duplicate check Designs against both Designs and Materials of the same material type
–Search and filter Designs by Assigned CRO
–Capture Design ID on Reactants, Products, and Samples created from Designs
–Synergy Experiment properties can be configured to inherit from Collaboration properties
–Share Synergy Experiment Templates to CRO Department(s)
–Append Template to Synergy Experiments for CRO users
–Configuration Transfer support for Reference Table definitions
–Publish Admin Defined Tables from Synergy Experiments to Inventa – available to all systems”
Chemistry
–Show/hide residue IDs of biopolymers
–Auto-pair tool now accepts RNA/DNA strands with pendant Chem or peptide monomers
–Enhanced selection behavior for atoms, bonds and structures
–Attach Data can now be added as chemically significant
Admin Defined Tables & Variation Tables
–Include Component Headers in Variant Calculations
–Update to Publish Variation Table to support variable measures in headers and columns
–Variation Table Vertical View update for variant hidden rows
Samples
–Moles calculation in Samples utilizing Radioactivity
Plates
–Addition of Mass (g) to Amount Annotation Layer in Plates
Inventory
–New label
–Update to Internal Request workflow to include Material ID of registered Samples
Materials
–Bulk import with multipart GenPept and Swiss-Prot files
Administration
–Spotfire for Signals Access Workflows privilege available
–Internal Data Sources now available in Autotext available to all systems
–IDS checkbox to allow admin to specify which sources are available in text element
Integrations & APIs
–API for Sequence pairing from two chemical drawings
–API enhanced to export plates as CSV
–API to modify CRO users
–API to fetch CSV example for bulkImport
–API with additional criteria for Data extraction from SDF

We also fixed several small bugs in this release. Details of the enhancements are described below.

Data Factory Administrators should be aware that the maximum number of measurement attributes has been increased to 7000

Data Factory Administrators should be aware that Dataset warnings are now presented in reverse-chronological order (up to 100)

Data Factory Administrators should be aware that the primary API GET /job-service/job has been deleted

This content is anticipated for release on our Production E3 environments, and for Private Cloud customers on our deferred release schedule, in November 2025.

Further Details

Fundamentals

The audit trail now captures the initial state of content when copying a system template, experiment, or personal template. When content is copied, the audit trail logs both 'created' and 'edited' records showing the previous version with the initial content. This enhancement applies only to newly created content and is not retroactive.

AI

The Swagger page for Notebook APIs has been enhanced with better Schema information for API responses. This is in preparation for providing access to YAML files to facilitate SDK Generation through OpenAPI tools.

SAR & Decisioning

The Assay Details preview section of Inventa Analyses now supports the display of internal references

Integrated Summary App support “Is Any Of” for numeric attributes, allowing users to search for a set of numeric criteria.

Synergy

Normalized Compounds are now supported in Synergy for both Designs and Reference Tables. The Normalized Compounds libraries facilitate the registration of materials with a salt-stripped structure as an asset, while still retaining the original raw structure for the batches associated with that asset. Salt stripping is valuable when working with CROs that deliver compounds. To enable a material library of type Normalized Compounds, activate the library for Synergy in Signals Configuration and then configure Designs and Reference Tables in Synergy Configuration.

Release 25.6 also brings several new features in Synergy related to Designs. First, when creating or importing Designs, Designs can be checked for uniqueness against Designs only or Designs and Material Assets of the same Material type. The Administrator can change this setting under the Uniqueness Rules for each Material type in Signals Configuration.

Designs have a new property called Assigned CRO. Assigned CRO is automatically captured when a Design is added to a Work Order for a CRO. Designs can be searched and filtered by Assigned CRO in both Advanced Search.

When a CRO user or Sponsor user adds a Design to a Chemical Drawing as a Product or Reactant, the Design ID is captured in the Design ID property in the stoichiometry grid. The Design ID is propagated to subsequently created Samples. If the Sample is then registered, the Originating Design will be added to the Material and the Design status updated to Synthesis Complete. If the Design is added as a Product, the Design ID is also added to the Reference from W.O. property of the Synergy Experiment for ease of search for related Synergy Experiments.

Synergy Experiment Template attribute list fields can be configured to inherit the property from the parent Collaboration. If a field is set to inherit, the field will be automatically populated with the corresponding value from the parent Collaboration on the Draft Synergy Experiment and all subsequent Synergy Experiments created by the CRO users. As a result, the Sponsor or CRO user does not have to repeatedly populate the same property, such as Project Code or Disease Target.

CRO users can now Append Template to a Synergy Experiment. This allows CRO users to add additional content for specific use cases. The Synergy Administrator can share Synergy Experiment Templates to CRO Department(s).

Finally, Configuration Transfer now supports the transfer of Reference Table configuration settings.

The ability to publish Admin Defined Tables (ADTs) to Data Factory from Synergy Experiments is now available to all systems. Similar to the publication functionality in internal Experiments. Properties of the Synergy Experiment, including those that are Hidden from CRO, and columns of the Tables can be mapped to measurement type attributes in a specified Data Factory project and published by the Sponsor user.

Chemistry

The auto-pair tool has been improved to work with a wider range of RNA and DNA strands. This enhancement allows strands that include additional Chem or peptide monomers when finding the complementarity between strands and placing hydrogen bonds between them.

There is now enhanced visualization in ChemDraw when atoms, bonds and structures are selected on the canvas. ChemDraw now individually highlights all the atoms, bonds and structures that are part of the selection, in addition to the selection box that appears upon selection on the canvas. This provides a clear distinction between selected and unselected elements on the canvas.

When annotating a molecule or stereocenter in ChemDraw using the 'Attach Data' capability, annotations can now be specified as 'chemically significant'. When this option is selected, annotations become chemically significant and are recognized and honored in chemical searches. Additionally, users can now edit existing annotations by selecting them and reopening the 'Attach Data' dialog in ChemDraw.

Admin Defined Tables & Variation Tables

Headers in Components in Variation Tables can now be used in calculations in Variants. The Variant Headers can be found in the selectable properties or can be entered manually.

Update to Publish Variation Table to support variable measures in headers and columns. Administrators can now map variable measure field(s) from both columns and headers for both Components and Variants:

Variation Table Vertical View update for variant hidden rows now is darker gray and will not allow users to type in cells associated with hidden rows:

Samples

A new Moles calculation in Samples utilizing Radioactivity and Molar Activity is now available. If the user enters Radioactivity and Molar Activity values for a Sample, Moles is calculated as “Moles = Radioactivity / Molar Radioactivity”
If the user subsequently enters an Amount on the sample, Moles will be recalculated using the Amount and FM as is standard.

Plates

Users can now enter values in the Amount annotation Layer utilizing Mass (g). Values with this new unit are included in the table and export just as the previously available volume amounts.

Inventory

A new 48 by 16 mm label is designed to have the QR code fit inside of a circle that can be added to the top of a tube. The 1-D barcode was designed to fit on a rectangle label next to the circle label and put on the tube vertically:

Update to Internal Request workflow to include Material ID of registered Samples. When users register a Sample from the Samples table the Material ID will automatically be filled in.

Now in the Internal Request, users will see the Sample ID, the Containers and the Material ID as an option to select from:

Materials

Multipart GenPept, FASTA, and Swiss-Prot files can now be bulk imported into a Proteins material library. Workflows are available to bulk import a collection of single sequence files (current capability), a single multipart file and corresponding meta-data (via .zip folder), or a single multipart file with fixed values (via multipart .gb or .fa file).

Administration

Spotfire for Signals Access Workflows privilege available to control which users can access and substantiate a Spotfire for Signals Workflow. Also controls who can import and export workflows. Users without this privilege can still leverage Workflows embedded within shared DXPs.

Internal Data Sources now available in Autotext available to all systems. Additionally, Admins are now able to select which Internal Data Sources are available for use in the text element by selecting the checkbox on the IDS in the SN Config.

Once the Admin Enables the IDS in the text element, users will be able to select the IDS to utilize in snippets or in the text element.

Integrations & APIs

This update brings new APIs to support modifying CRO users in Signals Synergy. Synergy Users for a provided CRO may be updated in bulk. This is an asynchronous API that allows the bulk update status to be checked once initiated via the POST API. The POST API takes a CSV files with User ID,Email,First Name,Last Name,Country,Alias,Licenses. Field are optional as when applicable.

Plates can now be exported as CSV via the External API. To download the plate as a CSV set the “format” URL parameter to “csv”. The default format will be a JSON file if not specified.

The example zip for material bulk import can now be specified to contain a CSV example. To download the zip with a CSV example set the “dataFileType” url parameter to “csv”. The default data type will be SDF if not specified.

A new API has been added to pair two single oligonucleotide sequences and create a chemical drawing of the paired sequence.

The request takes an eid of a parent as a URL parameter and the body takes two chemical drawings each containing a single oligonucleotide sequence as well as a parent entity. If the pairing is successful a chemical drawing of the resulting pair is added to the provided parent entity.

The parent entity must be capable of having a child chemical drawing.

Two new endpoints have been added to Signals Data Factory for exporting data from projects.

These endpoints will all or a specific measurement type data by Project.

The request will allow for, and the response will contain a search ID and last document id. Providing these in subsequent requests will allow for pagination, and to only capture data that has comes after the provided last document id.

An optional request body can be used to filter the results further.

For all measurement types you can filter on: Entity, Attribute(s), and Tag(s) as well as specify which fields you want returned in the results.

For individual measurement types you can filter on: Entity and Attribute(s) as well as specify which fields you want returned in the results.

Further Details

Data Workflows & Analytics

For tenants with a Signals One license, users will now be able to perform In Vitro (screening, assays) data analysis, visualization and results quality control. The first curve fitting method available, is the logistic 4 Parameter (4P) fit.

Parsing of instruments output files is now directly available in Signals One to generate analytics-ready tabular data. Some System parser definitions for Revvity plate readers (e.g. EnVision, EnSpire, Operetta,…) are provided out of the box:

The data from the instrument output files can be enriched with the information about the plate format and the materials tested to provide all the information required for the visual analytics steps:

The analysis and visualization is organized in steps. Currently, normalization:

and 4P curve fitting steps are available:

Each curve can be controlled in detail and outliers excluded from the analysis at the level of the data points or even whole curves:

SAR & Decisioning

Minor automapping enhancements were introduced to the Publish Results to Data Factory to prioritize the optimal match, even if the same data table column is associated with multiple attributes.

What's New

We are delighted to release our new version of Signals, 25.7. This release brings enhancements in Signals Synergy, our ChemDraw sketcher, Tables, Samples, History, Inventory, Plates and Materials. We have new beta capabilities enabling Semantic Search and extended beta capabilities around the in vitro analysis object, updated data factory and supplier lists. Finally, we have also fixed a number of small bugs.

Fundamentals
–The audit trail for System Templates and Experiments captures the previous and current versions of Layout Changes for actions including Rename Page, Add Page, Delete Page, & Reorder Page
–The “Updated User” audit record within the Admin Audit Trail displays current and previous versions of the specific changes to User metadata
AI
–Semantic Search (beta)
Data Workflows & Analytics
–Preview of the assembled data in Vitro Analysis (beta)
– Calculations can be applied when analyzing two instrument readouts in Vitro Analysis (beta)
– Re-execution of Analytics steps in Vitro Analysis (beta)
– Improved error handling in Vitro Analysis (beta)
SAR & Decisioning
– Inventa Analysis SAR Groups preview can now be filtered by Data Factory project
– Integrated Summary App now supports well-level details within the combined unsummarized table.
– Target Engagement Profiler now uses “continuous” as the default x-axis
– Data Factory projects now support Custom Entity data and Material Sync (beta)
Synergy
– Bulk fill values in Reference Tables for selected rows
– Sharing of batch salt information to CROs in Reference Tables
– Status Modified field and filter for Designs and Work Orders
– Notifications for internal users and groups assigned to Designs
Chemistry
– View basic chemical properties in the Analysis panel
– Add chemical properties directly to the ChemDraw canvas
– Hydrogen-bonded fragments are treated as a single structure
Admin Defined Tables & Variation Tables
– Update to Material selection from experiment to include Name
Samples
– Inclusion of Reaction ID in Sample Update Modal
Plates
– New Properties Annotation Type
Inventory
– System Supplier List available in new Material Library (beta)
– Exponential notation update on Container Amount on Batch/Lots
Materials
– Bulk import of salts for compounds
– Bulk update of salts & solvates for materials
– 'dd-MM-yyyy' date format for bulk import
Integrations & APIs
– New API to recall Synergy Work Order
– New APIs to move locations to new parent locations
– New API for creating a material from a material table
– Download option for Notebook API Yaml Files

We also fixed several small bugs in this release. Details of the enhancements are described below.

Administrators should be aware that the stereochemical annotation of pseudochiral OR centers using the guided stereo tool will change to add an additional label which will interpreted as chemically significant. This change will occur in a future release and only apply to annotations made subsequent to the change, existing compounds will remain with the prior understanding until edited.

This content is anticipated for release on our Production E3 environments, and for Private Cloud customers on our deferred release schedule, in November 2025.

Further Details

Fundamentals

When a user updates the Layout for System Templates and Experiment-like objects, the audit trail captures previous and current versions for the layout changes including Rename Page, Add Page, Delete Page, & Reorder Page. This change only applies to content updated after the update.

Additionally, when an admin updates metadata within a User’s profile, the “Updated User” audit record within the Admin Audit Trail displays current and previous versions of the specific changes to the user’s metadata.

SAR & Decisioning

Inventa Analysis users can now filter SAR Groups data by Data Factory project to focus on the most relevant data.

Users can now include Details-level measurement types in the Combined Unsummarized Table within the the Integrated Summary App.

The Target Engagement Profiler now defaults to “continuous” x-axis when viewing Concentration vs. Time, within a convenient checkbox to switch to a categorical view.

Synergy

Sponsors often need to provide additional information related to a specific Design or Material (ExID) using Reference Table admin-defined fields. For example, a Sponsor may need to indicate which assays to run on specific compounds or the amount and minimum purity requested for each Design being synthesized. Sponsor users can now Bulk Fill values in Reference Tables using copy-paste from cells within the table or from an excel or csv file.

In addition, users can also Bulk Fill multiple cells in a column with the same value. After selecting a set of rows, users choose a column from the Bulk Fill menu and then enter or select a value. After pressing Bulk Fill, the same value is applied to the cells in all selected rows.

Salt information for a batch may be very important for a CRO to know when running an assay or analysis. Thus, Salt information can now be configured as Shareable to CRO in batch Reference Tables for Material libraries of type Compounds. When set to Shareable to CRO, a Sponsor can include the primary (first) Salt Name, MF, MW, and Coefficient in a batch Reference Table for a CRO Work Order.

When searching for Work Orders or Designs, it may be useful to search for those that recently changed Statuses. For example, which Work Orders were recently transitioned or which Designs were Proposed or Sent in the last week. Status Modified is a new properties on Work Orders and Designs available in Advanced Search and Smart Folder filters.

Finally, internal users and user groups now receive a notification (if configured) when a Design is assigned to them.

Chemistry

A new 'Analysis' panel in the ChemDraw editor now displays basic chemical properties for structures and biopolymers. These properties are context-sensitive, based on the selection on the canvas, and include information such as chemical name, molecular weight, molecular formula, and exact mass.

Specific properties from the Analysis Panel can be added directly to the ChemDraw canvas. Clicking the 'Add to Drawing' button at the bottom of the panel opens a window where properties can be selected and pasted onto the canvas.

Hydrogen bonded fragments in ChemDraw will now be recognized as a single structure with properties such as molecular weight, molecular formula and exact mass being calculated accordingly.

Admin Defined Tables & Variation Tables

Update to Material selection from experiment to include Name in Variation Table. Administrators will need to add the Material Name field and set it to be of type Variable Property. They will then be able to select the Name for the Variable Parameter and set the Material ID as the Internal Reference Column Name:

This allows the user when selecting material for the components in the Variation Table, to populate the Name (Chemical or otherwise) at the same time as the Material ID:

The user will see both columns fill in with data automatically:

Samples

To aid users in selecting the correct structure during the sample update process, we now include the Reaction ID in the sample update modal.

Plates

Users can now add a new Annotation layer type, Property. Annotation layers of type Property are collected in a properties tab on the plate and have a single value for every well in the plate.

Admins can add Property Annotation layers to plate templates as is currently done with other annotation layers. When end users fill in a value in a property, the value populates for every well in the plate table

Users can hide or edit the names of the property type annotation layers.

Inventory

Exponential notation update on Container Amount on Batch/Lots. Scientific notation will appear only after 5 digits (ex: mg in the screenshot)

Materials

For Materials libraries of type Compounds, Salts can now be included during Bulk Import. Salt Name and Coefficient can be matched to columns in an SD or CSV file. The Salt Name must match an existing system salt (Signals Configuration > System Settings > Salts and Solvates) and only one salt per compound batch is supported.

The ‘dd-MM-yyyy’ format (e.g. ’15-02-2019’) is now available as a Date Format option during bulk importing of materials.

Integrations & APIs

We have updated our Synergy API to support recalling of Work Orders.

PUT /synergy/workOrders/{workOrderId}/status now supports the “recall” action. A Work Order must be in the To-Do state for this action to succeed.

We have added new APIs to move a sub-location to a new parent location. This is an asynchronous API that follows our standard pattern of Begin Move Job, Check Status of Move and Download Report of Move. Only location that include the “movable” system property and have it enabled will be able to move to new parent locations.

We have also added a new API to register a new material from a material table. The table must be configured to allow for material registration in System Configuration. The row being registered as a new material must have all required data for the material to successfully register.

We have also added a method to download all the YAML files which back our Notebook Swagger page via Signals Configuration. This is to make it convenient to access these files for usage with SDK generation tools. They were tested with OpenAPI Generator.

Further Details

AI

Users with a Signals One license will now have access to the new Semantic Search. Semantic search is an AI-powered method of searching that focuses on understanding the meaning and context of a user's query, rather than just matching keywords. It leverages Natural Language Processing (NLP) and Machine Learning (ML) to interpret the user's intent and deliver more relevant search results.

To enable Semantic Search users just need to click the Sematic Search icon to enable semantic search.

Data Workflows & Analytics

The first rows of data assembled from multiple sources (instruments data, plates, external lookup tables,…) can now be previewed in the Data Assembly.

The Preview highlights the columns used for matching and the columns added to the instrument data. A column first added before being used for matching will have the column header highlighted as “Matched” and the content rows as “Added”. The Preview appears upon assembling the data when pressing the “Assemble” button.

Calculations can be applied when analyzing two instrument readouts in Vitro Analysis. Two instrument readouts can now be used (Read 1 and 2) and combined using a predefined calculation.

When user changes like exclusions or settings modification take place in the analytics steps, each step can be recalculated independently from the other steps using the new “Recalculate” button.

When the next step in the analytics is impacted, the recalculated button of the downstream step is enabled and the user notified that the steps are out of sync (e.g. normalization changes that impact curve fitting).

When potential problems are detected, warnings become visible in the user interface to help users identify early on the sources of problems.

In this example, the matching of two columns returns no rows, which is an indication of a wrong selection of columns to match.

SAR & Decisioning

Custom Entity data can now be published directly to Data Factory projects (beta version) from the Inventa Dashboard.

Inventa Sync now supports Data Factory projects (beta version). Map material libraries to projects using the new Data Factory Mapping section (accessible from the Material Management page), then activate sync on a per-project basis though the Project Activation and Status section.

Inventory

System Supplier List available in Material Library. Administrators can now add the System Supplier List to the Materials Library at both the asset level:

And the batch/lot level:

Multiple Fields can be associated with the System Supplier List and can be added to the Materials Table:

Users will see the fields in the Materials Table when they add them to an Experiment/ADO:

Bulk Import to a Materials Library supports the System Supplier List field type:

The mapping import screen as well as the example file supports the System Supplier List field:

What's New

We are delighted to release our new version of Signals, 25.8. This release brings enhancements in our Data Workflows and Analytics, SAR and decisioning, Inventory, Tables and Plates amongst others. We have new beta capabilities for Hierarchical Tables, Contextual Lists and extended beta capabilities around Supplier Lists, Data Factory and InVitro Analysis. Finally, we have also fixed a number of small bugs.

AI
–Admin options to enable/disable AI functionality in Signals One (Beta)
Data Workflows & Analytics
–Animal Selection & Group Assignment App with Randomization capabilities is no longer available
–Data Factory 2.0 Publishing (beta)
–Exclusion of Plates or individual Wells (beta)
–Analytics annotations (beta)
SAR &Decisioning
– System generated IDs can be used when publishing data to Data Factory (beta)
– Changes to Data Factory’s information design now propagate to published data (excludes legacy projects) (beta)
– ChemCharts manual sequence alignment visualization, HELM enhancements, and structure visualization improvements
Synergy
– Copy/Copy Partial of Work Order
– Bulk create Designs from enumerated Products in Parallel Experiments
Chemistry
– Drawing of individual RNA or DNA monomers is now supported in the HELM editor
– Selection and replacement of multiple monomers at once when using the HELM editor is now possible
Admin Defined Tables & Variation Tables
– ROUND function
– Hierarchical Tables (beta)
– Contextual Lists (beta)
Plates
– Load/update plate via CSV upload
Inventory
– 3 New labels
– Update to Export Containers for searches that return no results
– Additional Container Privilege for updating Home Location
– Search by CAS and select containers in Quick Add in Chemical Drawings
– Remove link to any container in the Materials Table
– Bulk Import Containers (beta)
– Update to Advanced Search for Home Locations with grid coordinates
– System Supplier List available in Chemistry Settings Configuration (beta)
Materials
– Option to utilize structure AND additional fields in uniqueness checking
– Total Cysteine Content (%) for protein sequences
Adminstration
– Privilege to create or use personal templates
– Privilege to copy experiments or entities
Integrations & APIs
– Enhanced APIs to allow RXN files for export and replacement of Chemical Drawings
– API enhanced for adding items to Stoichiometry grids without Chemical Structures
– New APIs for moving location content to a new location
– New API to create relationship links between entities
– API enhanced fetch all samples from a Samples Table
– New APIs to fetch and update Order details
– External Notifications for Work Orders
– New CRO specific APIs for interacting with Entities and Samples

We also fixed several small bugs in this release. Details of the enhancements are described below.

Developers should note that we are planning to address an issue with the GET /entities/{eid}/export endpoint, where currently the response returns an incorrect Content-Type header for Text entities. The header is currently set to text/plain, while the actual content is text/html. This only affects text entities created through text file upload. This will be corrected in an upcoming release.

Data Factory administrators should be aware that in an upcoming release you will no longer be able to create Legacy Data Factory projects. We encourage adopting the Data Factory beta features which will soon replace the current (legacy) projects.

System Administrators of E3 or Private Cloud systems using our validation ready deferred release should be aware of the upcoming change to our patch process. Starting November 2025, we will introduce a planned patch to E3 and select Private Cloud environments approximately 3-4 weeks after the update to Production. These patches will contain resolution to critical issues identified late stage during PQ testing or immediately post-Production. Note: These critical issues can include those not identified via a Sandbox tenant that were not fixed in sufficient time in our Standard releases to be part of the Production update. If no appropriate issues are identified, no patch will be released. The planned timing for the patch will be communicated in the Release Notes.

Administrators should note that the beta capability “Animal Selection & Group Assignment App with Randomization capabilities” is no longer available.

Administrators should be aware that the stereochemical annotation of pseudochiral OR centers using the guided stereo tool now will add an additional label which is interpreted as chemically significant. This change only applies to annotations made subsequent to this change, existing compounds will remain with the prior understanding until edited.

Data Factory administrators should be aware that you can no longer change the data type of an attribute to an incompatible format (e.g.: from chemical structure to date).

Data Factory administrators should be aware that secondary (AER) maps will now only be handled by the Data Factory backend. You can no longer create nor modify these maps manually. Consequently, the following are breaking changes in Primary APIs:
GET /information-design-service/import-maps/{importMapId} no longer returns secondary maps
POST /information-design-service/import-maps/search no longer returns secondary maps
POST /information-design-service/import-maps no longer allow the creation of secondary (AER) maps. This will return a 400 error if attempted. Query parameters and response fields related to secondary maps have been removed.

The following endpoints will no longer return fields related to secondary maps:
PATCH /information-design-service/mtypes/{name}
GET /information-design-service/mtypes/{name}
The following endpoints have been marked deprecated and will no longer include fields related to secondary maps:
GET /information-design-service/attributes/{attributeId}
POST /information-design-service/mtypes
PUT /information-design-service/attributes/{attributeId}

This content is anticipated for release on our Production E3 environments, and for Private Cloud customers on our deferred release schedule, in March 2026

Further Details

SAR & Decisioning

The ChemCharts “Manual Sequence Alignment Visualization” allows users to manually align biological sequences (including HELM). Drag to align single or multiple residues and modify gaps as needed.

The ChemCharts HELM visualization introduces a handful of customer-requested helper data functions.

Convert biosequence formats using the BILN to HELM data function.

Extract all monomers or monomer units from HELM into a set of columns

Perform HELM substructure or similarity searching using a powerful graph-based comparison of query structure and target structures.

Optionally use a local data table as a monomer source

ChemCharts now supports SVG image format within Table/Gallery visuals, and the Embed Image data function.

There are minor enhancements to the Kinome, Chemistry, Gallery, and Table ChemCharts

In the Kinome visualization, optionally use column names as node labels.

In the Table visualization, there is a new visual indicator for columns with a shadow column assigned.

The Chemistry visualization now supports defining a default structure column, enabling/disabling tooltips for structure search images, specifying the image size in structure searches, and importing/exporting structure searches

Gallery visualizations can now be exported to PDF

Antibody and Nanobody data functions, including Developability Dashboards, now support the ABodyBuilder v3 model

Use the new “Extract Sequence from GenBank” data function to output the sequence into a new column.

Synergy

Sponsor users with the new privilege Clone Entities can Copy or Copy Partial Work Orders. This allows the Sponsor to easily send the same compounds for another assay or easily repeat common Work Orders.

After enumerating Products in a Parallel Experiment in Signals, a Sponsor may want to synthesize the products internally or send the Products off to a CRO for synthesis. On a Sub-Experiment/Products Table in a Parallel Experiment, a Sponsor can now Bulk Create Designs. Created Designs are marked with the Originating Experiment for traceability and are easily sent off in a Work Order for synthesis at a CRO.

Chemistry

Support for drawing individual RNA/DNA monomers has been added to the HELM editor. When editing in the RNA/DNA tab of the HELM Editor, there is a new "None” option available in the dropdown menu for secondary monomers. When “None” is selected, a monomer of that type will not be drawn when the primary monomer is added to the ChemDraw canvas. Additionally, if the user wishes to draw using only the primary monomer (ribose, base or phosphate), a modifier key is available. Selecting alt/option + the monomer will only add the primary monomer to the canvas.

Bulk selection of monomers while in HELM edit mode is now possible by using the 'Shift' key and selecting multiple monomers on the canvas. Once selected, these monomers can be replaced simply by selecting a new monomer in the HELM editor.

Admin Defined Tables & Variation Tables

A new function “ROUND” is available in table calculations, to supplement our exiting ROUNDUP and ROUNDDOWN functions. ROUND uses the method “Rounding half away from zero”, an optional second argument allows definition of which position relative to the decimal point the value is rounded to. If the second argument is absent, the value is rounded to the nearest whole number.

Plates

Users are now able to load or update Plates via a csv upload by selecting “Update plates from csv”.

This brings up a mapping modal which allows the user to map columns from their csv to the associated annotation layers.

Once imported the plate is updated.

Inventory

3 New Labels:
25 x 18 mm:

12 x 12 mm:

89 x 25 mm:

Update to Export Containers for searches that return no results. If the data changed during the export the job would not finish, Users will now see a failure message on the page:

And on the report page:

Additional Container Privilege for updating Home Location. Now users can be given the privilege to update a container’s Home Location. Previously this was reserved for System and Inventory Administrators. Users still need security access to the containers as well as Edit Container privilege to update the Home Location:

Once the user has the privilege to update the Home Location, they can use the vertical 3 dots in the top right corner to open the Edit menu:

Search by CAS and select containers in Quick Add in Chemical Drawings. When users type a CAS number in the Quick Add, associated containers will show as an option:

Users then select the container they would like to add to the Chemical Drawing:

Remove link to any container in the Materials Table via the unlink icon:

Update to Advanced Search for Home Locations with grid coordinates filter:

Users can select a location with a grid coordinate to find which container is supposed to be in that location:

Materials

Admins now have the option of utilizing both the structure rules AND material fields in uniqueness checking during material registration.

This is an addition to the existing OR option for uniqueness checking. If AND is utilized, a duplicate will only be identified with there is a match on the Structure AND all selected rules.

These options are deactivated if the Structure rules are turned off as all fields will be utilized regardless of selection.

Calculated total cysteine content (%) is now available for Protein materials.

Administration

Admins can set a privilege to control users’ ability to copy experiments or entities. The “Clone Entities” privilege allows users to copy and partially copy experiments, and content entities within an experiment. Disabling this privilege from all roles for a user will disable the their ability to copy content.

Admins can also set a privilege to control users’ ability to save or use personal templates. When the “Save as Template” privilege is disabled for users they cannot save nor use Personal Templates.

When admins disable both the ‘Clone Entities’ and ‘Save as Template’ privileges, end users are forced to use the latest definition of a system template when creating an experiment.

Integrations & APIs

We have updated our APIs to allow for exporting and replacement of Chemical Drawings with RXN files. A replaced Chemical Drawing will maintain the entities ID while replacing the content from the provided RXN file.

We have added new APIs for adding custom products and reactants to Stoichiometry grids. This enables the ability to add either a product or reactant to a stoichiometry table without need of a chemical structure.

We have added new APIs for moving location content to a new location. This will move all the containers in a location to another location. You will need to provide an option for handling duplicates as part of the request.

The API is asynchronous and kicked off in three steps: Create the Move Content Job -> Check the Status of the Job -> Get a report of a completed Job.

We have added a new API to create relationship links between entities. The type of relationship: related, repeats, repeated_by, duplicates, duplicated_by, precedes, or preceded_by is required for creating the link.

We have updated our API to allow fetching all Samples in a Samples Table.

We have added new APIs to fetch and update Material Orders.

For our Synergy product we have added External Notifications for Work Order signing Events. These are included in the Notification Trigger “All Signing Events”.

We have added new APIs specific to our Synergy Product CROs. These allow for specific APIs to be utilized by CRO users. This enables customers External Actions to read and write for CRO users without exposing details that CROs are restricted from seeing or interacting with

Further Details

AI

Administrators will now be able to enable or disable new AI features utilizing the AI settings options. AI features still require a Signals One license and infrastructure to function. This just allows the admin more granular control on when these features are made available to end users.

Data Workflows & Analytics

It is now possible to define the mappings of the raw data and curve fit results with the Measurement Types of a Data Factory 2.0 project in the In Vitro Analysis templates.

In addition to the raw data and curve fit results, which are interrelated, a set of general properties can also be mapped for publication.

The users of an In Vitro Analysis template with publishing activated can decide whether both raw data and curve fit related tables or only one of them should be published for their analysis.

In addition to the exclusion of curves and curve data points, it is now possible to exclude whole plates or plate wells from normalization.

The exclusions at the plate or well level affect the normalization and the curve fitting downstream. Therefore, the users are notified that they should recalculate the normalization results.

Successively, downstream steps dependent on the normalization, like the curve fitting, will also need to be recalculated and the user gets another notification.

Plate, well, curve and point-level annotations are now embedded in an In Vitro Analysis.

All the annotations can be reset and result recalculated in a row by clicking on the global RUN button, while the recalculate buttons maintain the annotation.

SAR & Decisioning

System generated unique result IDs are now available for use with Data Factory (beta) projects in Signals One. When enabled by an Administrator, unique identifiers will be automatically generated for any empty ID values during publication, while preferentially using any explicitly provided identifiers. This feature does not apply to legacy projects.

Data Factory will now propagate changes in entity, attribute, or measurement type design to maps and published data. When making a change to the information design, administrators will be warned if the change will require data reprocessing. Once an admin makes a change requiring data reprocessing, newly published data will be inaccessible until after the admin selects “Reindex Now”, and data finishes processing. When reindexing, all design changes are applied to any existing data or newly published data. Any existing admin-defined maps will continue to work.

When an admin has made changes that require data reprocessing, end-users will see a “New Data Pending” notice, indicating that access to newly published data may be delayed. Previously published data will remain accessible during this time. The label is removed once data finishes processing.

Admin Defined Tables, Variation Tables and Hierarchical Tables

A new tabular content type, Hierarchical Tables, has been added. Hierarchical Table Templates can be defined by an administrator in the Table Templates folder. Hierarchical Tables can contain multiple table layers, with association between an upper row in a table and one or more rows in the lower table, to provide layers of data containing different levels of detail. Hierarchical Tables require the end user to have a Signals One license.

The association between rows can be indicated with “propagating down” an identifier value from a row above. Rows from multiple associated upper rows can be displayed, to add rows however a single parent must be selected.

Available property types include a similar library to in Admin Defined Tables, such as Text, Number, Date/Time, Internal Reference etc. Equations in a table layer or between table layers, or Headers, can be defined. Number properties can also be defined with conditions for data entry, ranges can be set and the property set to either not allow an out of range value, or to provide a visual indication when a value does not match.

A new property type, Contextual Picklists, have been added to ADTs, Variation Tables and Hierarchical Tables. Contextual Picklists allow an administrator to define a logic for generation of a dropdown list, where the values for the list are sourced from other content within the system. This capability is only available to users with a Signals One license.

The source of the list can be defined as coming from the Experiment the user is in. The source is further defined as to the content type, such as an Admin Defined Table. Depending on the content type, the source is further refined to identify the Origin Template. Finally, the Property where the values are found is defined. A dropdown list of the unique values, given the prior definition, is presented to the end user as a dropdown.

The source for the list can also be defined as a different Experiment or similar object (Admin Defined Object etc.) The other Experiment must be defined in the table with an Internal Reference type field.

In addition to choosing data from table type objects, the values in the list can also represent the names of the content items within an Experiment by selecting the option “Experiment child elements”.

The values in the list can also represent the Variant Names from Variation Tables to aid in associating testing or other data on those Variants by selecting “Variant Names” after selecting the Variation Table and Origin Template.

Inventory

Bulk Import Containers into Inventory. Users need to navigate to Inventory, to the Add New menu:

Select a Container Type to activate the Example download and the File Upload:

A csv example file will be created based on the container type properties:

Users need to be able to create containers and have (at least) read access to locations to import containers:

Once the import is started, the progress will be displayed at the bottom of the screen:

When the import is complete a report will be created. If there are any errors, they will appear in the report and the containers with errors will not be created.

Once complete, the users will be brought to the containers search table with the filter pre-set for the date:

System Supplier List available in Chemistry Settings Configuration. Navigate to the SN Config Chemistry Settings to create a column using the System Supplier List option:

Users will see the column in the stoichiometry table with the favorite suppliers at the top of the alphabetical list:

What's New

We are delighted to release our new version of Signals, 25.10. This release brings enhancements in versioning, equations, Variation Tables, Inventory and Synergy amongst others. We have new beta capabilities for viewing published data from Material libraries and around calculating protein properties. We have extended beta capabilities around Hierarchical Tables and Contextual Lists. The beta capabilities around text extraction from images and publishing samples are now available to all systems. Finally, we have also fixed a number of small bugs.

Fundamentals
– Origin Template (Original Name) property for versioning
– Increase of Task creation limit to 2000
AI
–Text Extraction from Images for Signals One customers available to all systems*
–Admin options to enable/disable AI functionality in Signals One available to all systems*
Data Workflows & Analytics*
–SPR Data Import App available in Spotfire for Signals now supports Carterra file schema versions up to 10
SAR & Decisioning*
–View Published Data from Material Library (beta)
Synergy†
–Failed Status on Work Orders
–Choice of Work Order transition when submit the only Synergy Experiment
Chemistry
–Inclusion of Barcode to Internal Enumerator mapping
–Inventory Decrements from Parallel Experiments
–Context-sensitive ChemDraw floating toolbar
–Drag-and-drop RXN files onto the ChemDraw canvas converts to CDXML
–Atom numbers can now be enabled via a checkbox in the Properties panel
Admin Defined Tables, Variation Tables and Hierarchical Tables
–Calculate Number with Unit from a Number property
–Calculate Maximum
–Publish Samples available to all systems
–Updates to the Internal Reference Column Name Configuration
–Addition of Internal Reference Lookup in Variation Table
–Copy/Paste with Hidden Rows in a Variant Table
–Internal Reference type properties can be used as source for Contextual Lists (beta)*
–Search of Hierarchical Tables (beta)*
–Hierarchical table data optionally included in exported PDF (beta)*
Inventory
–Updates to Bulk Container Import
–Return Containers to Home Location
–Updates to Container Aliquot Workflow
–Create Sublocations from Parent Location
–Deleted Locations removed from Recent Locations
Materials
–Loading Measure Added to Number with Unit in Materials
–Update to Batch/Lot page
–Calculated properties for protein complexes (beta)
ELN Archive
–Preview ELN Archived Experiment Types directly in search results
Administration –Update Definition privilege
–Spotfire for Signals Custom Apps Configuration available for Private Cloud now tracks Custom App module version*
–Configuration Transfer of Contextual Lists in Worksheets (beta)
–Configuration Transfer of Hierarchical Table Templates (beta)
–Hierarchical Tables included in Configuration Report (beta)
–Contextual Lists included in Configuration Report (beta)
Integrations & APIs
–New API for exporting Orders
–New APIs to support Supplier List
–Enhanced APIs to support Supplier List Fields
–Enhanced API for Text element export
–New API to replace Chemical Drawing with a Duplex
–Enhanced API to allow expanded chemical formats for uniqueness checking
–New API to update Synergy Experiment Status
–New API to close Synergy Work Orders
–Enhanced API to allow creation of Work Orders with templates

* Requires Signals One license
† Requires Signals Synergy license

We also fixed several small bugs in this release. Details of the enhancements are described below.

Administrators should be aware that the Normalized Compound Salt Stripping tool will change to better handle fractional coefficients by altering how multi-fragment salts are interpreted from the Salt List. This change will occur in a future release and only apply to registrations subsequent to the change, existing compounds will remain with the prior understanding until edited.

Developers should note that this release addresses an issue with the GET /entities/{eid}/export endpoint, where the response returned an incorrect Content-Type header for Text entities. The header was set to text/plain, while the actual content is text/html. This only applies to text elements created through text file upload.

Data Factory administrators should be aware of several important updates. The latest version of Data Factory has officially exited beta, and all older versions of Data Factory projects and apps are now designated as “Legacy.” As part of this transition, it is no longer possible to create new legacy Data Factory projects through the user interface. We strongly encourage administrators to begin adopting the latest Data Factory features, as legacy projects will be fully deprecated in a future release. A simple migration path will be provided in a future release to support this transition.

Data Factory administrators should also note that the Advanced Security policies in Inventa apply an “AND” logic across all user groups, restricting access if any groups lack permissions. This behavior differs from the standard Signals security model and will be fixed to align with the standard in a future release.

This content is anticipated for release on our Production E3 environments, and for Private Cloud customers on our deferred release schedule, in March 2026.

Further Details

Fundamentals

A new property, called “Origin Template (Original Name)” is now captured on templated content such as ADTs, Variation Tables, Hierarchical tables, Worksheets and Experiments. This searchable property captures the name of the template used to create the item. Unlike the existing Origin Template property, which updates to reflect the current name of the Template will show the name at the time of creation. For items where the definition can be updated, the captured value will be updated if you update the definition. This allows the name of the template to be used to indicate and update the version of the definition. Note that this property is only present for content added or updated after this change.

Users will now be able to create up to 2000 tasks at a time through the task creation modal and via bulk actions. It should be noted the behavior of task creation is unchanged only the limit has been extended.

AI

For tenants with a Signals One license, users will now be able to utilize AI to extract and search by text from Images uploaded to Signals Notebook. This includes files of JPEG, PNG, and TIFF. This will apply to newly uploaded images only. Should a use load an image similar to the one below they would be able to search for it using keywords from the image like Control, Norovirus, etc.

Data Workflows & Analytics

SPR Data Import App available in Spotfire for Signals now supports Carterra file schema versions up to 10.

Synergy

Sometimes a CRO is unable to successfully complete a Work Order for the Sponsor. For example, synthesis of a Design may fail, even after several successful steps or attempts, each submitted as a Synergy Experiment. Thus, at the time of Work Order submission, the CRO can alternatively submit a Work Order as Failed and provide a reason. The new Failed status is represented on the Work Order Kanban Board and included as an available External Notification.

Previously, in the case where there was only 1 Synergy Experiment for a Work Order, submitting the Synergy Experiment automatically submitted the Work Order. We now allow the user to choose how to transition the Work Order when submitting the 1 Synergy Experiment. The user can Submit the Work Order along with the Synergy Experiment, Fail the Work Order as they submit the Synergy Experiment, or do nothing to the Work Order (e.g., desire to continue adding more Synergy Experiments to the Work Order).

Chemistry

The barcode can now be mapped as part of importing SDFs into the Parallel Experiment internal enumerator along with the container ID. These values should also be visible in the stoich grids for the enumerated subexperiments.

We are now able to support Inventory Decrements from Parallel Experiments. Users may need to unhide the Inventory Decrement, Container ID and Barcode in the table:

Add New Compounds:

Containers will automatically update from Available to In Use and the Current User will update from Unassigned to the logged in user.

Scan or type the barcode into the search bar:

Add the container to the enumeration:

The container ID and Barcode will appear in the table. Users need to type in the full amount they will be removing from the container in the Inventory Decrements. This means that the user needs to know how much they will need for each sub experiment and put the total of that in the Inventory Decrement. This saves the user from having to navigate to every sub experiment to put in the Inventory Decrement:

Once the user types a value in the Inventory Decrement, the Current User, the Status and the Amount Available will be automatically updated. Users need to type in the Inventory Decrement before they enumerate the reaction:

Once the reaction has been enumerated, the Inventory Decrement column can no longer be updated:

Each sub experiment will show the Container ID and the Barcode, but not the Inventory Decrement column. This is done on purpose, so that users do not try to update the Inventory Container from a Sub experiment:

The ChemDraw editor now includes a context-sensitive floating toolbar. When content is selected on the ChemDraw canvas, a toolbar appears above the selection, displaying commonly used tools based on the selected object. As the pointer moves away from the toolbar, it automatically hides to minimize disruption to the editing process.

RXN files can now be dragged and dropped onto a ChemDraw canvas and converted automatically to cdxml for continued editing.

Atom numbers in ChemDraw can now be enabled for a selected object by selecting 'Show atom numbers' in the Atom section of the Properties panel

Admin Defined Tables, Variation Tables and Hierarchical Tables

Configuration Administrators can now define an equation to convert Numbers to Number with Unit properties. The CONVERTNUMBER function can be applied to properties of type Number with Unit. The function follows the format CONVERTNUMBER(Arg1, Arg2, Arg3) where Arg1 is an input property of type Number, Arg2 is the unit within the measure to apply to the Number. Arg3 optionally allows conversion to a different unit within the Measure.

A Configuration Administrator can also define equations to calculate the maximum of a series of data. The functions MAX and MAXOVER allow the selection of the largest of a set of data. If applied in a Header, the conditional maximum can be calculated using MAXOVER or by nesting an IF functions within MAX.

Publish Samples is now available to all systems. We’ve made an update to the Internal Reference Column Name drop down. When using the Internal Reference in configuration, the ability to refence the Internal Reference is not available for fields set to Multi-select. This has been updated to prevent misconfigurations.

If Multi-select is checked the Internal Reference is no long available to select in the Internal Reference Column Name:

Variation tables with hidden rows in the variant can be copy/pasted into. The hidden rows will be skipped over and the values will be added to the next row that is visible:

We’ve added a new Type in the configuration of the Variation Table. This is called Internal Reference Lookup. The purpose of this type is so that the administrator can configure a multi-select (from Materials already referenced in the experiment) that will put the materials into separate rows in the Variation Table.

Administrators should select the new Internal Reference Lookup from the Type drop down menu. Only 1 Internal Reference Lookup column is allowed per table so that the magnifying glass icon is associated with only one Internal Reference Lookup column. Administrator will need to select the “Limit Materials to same containing entity…” The “Show Lookup Icon…” will be automatically selected and greyed out:

When users make a new table in the experiment, they will see the magnifying glass in the top right corner of the table:

When users select the magnifying glass, they will see a list of Materials that are already referenced in the experiment. They can multi select all the Materials they would like to add to the Variation Table:

Selected Materials will be added in separate rows in the Variation Table:

Under the Property Type column Administrators can now choose Sample Properties as an option to be printed on the container labels:

We’ve made an update to the Bulk Container Import to have separate columns for the Material Library/Sample Type and the Material ID (Asset + Batch/Lot). This means that the example files have been updated and any template files that were used previously to bulk import containers, will need to be updated to have the additional column to import the data correctly:

Users can now return a series of containers to their Home Locations. Users can Search or filter for the containers that they would like to have returned to their Home Location on the Containers Search Table:

Once the containers are selected, and the Return to Home Location has been selected the containers with Home Locations will be updated. Any containers with out a Home Location will remain in the Current Location and they will be shown in the report as failures:

You can now split a container into multiple sub-containers with an option to make all aliquot amounts identical. This helps save time and reduce manual entry when preparing multiple identical vials.

Admins can now create a new sublocation directly while viewing a specific location. The parent location is automatically pre-filled in the creation form, making it faster and easier to build hierarchical location structures.

When a user selects a deleted location from the Recent options list, the system now displays a warning: “Location entry could have been trashed or may not exist. Please select a different location.”

After this warning the trashed location is removed from the Recent options list and cannot be reselected. If the user navigates away and returns, the deleted location will not reappear in Recent options. All workflows involving location selection will automatically exclude deleted locations going forward.

Materials

Admins can now utilize the measure Loading (mmol/g) for Number w/ Unit properties in Material Libraries and utilized in Sample mapping.

The Inventory Container Amount column has been moved to be next to Location:

ELN Archive

Support for previewing ELN Archived Experiment Types across all search result views

Administration

Administrators can now define if user can update the definition of tables and Worksheets. The Author privilege “Update Definition” will determine if the Update Definition option is available to users.

Signals One Private Cloud environments with Spotfire for Signals Custom Apps enabled now track module version of Custom Apps.

Integrations & APIs

We have added new APIs for exporting your Orders to a CSV or SDF file. The default value will be CSV. This is an asynchronous API flow with three endpoints to support it. First to initiate the bulk export, this requires a request body specifying the Orders you want to export and the columns you want to export. Second is to check the status of the export job. Third is to download the exported file.

We have added new APIs to fetch and update the Suppliers list. The update requires a well formatted CSV as part of the request. For convenience an example CSV is available via API.

We have enhanced APIs for stoichiometry tables, materials (assets and batches), and containers to support Supplier list field types. You will be required to specify the supplier list by the supplier ID as fetched in the new APIs. Alternatively, the Name and Country of the supplier may be used instead. Below are examples for Assets, Stoichiometry tables, and Containers using the supplier ID.

We have enhanced the entity export API to allow for Text entities to be exported as text files. This is specified using the “format” URL parameter which defaults to HTML if not specified for a text element.

We have added a new API to replace an existing chemical drawing with a paired duplex. The request body must contain two Chemical Drawing entities to be paired.

We have enhanced the API for uniqueness checking of a material to allow for additional chemical structures to be used. The content type must be specified as part of the value object for Chemical Drawing fields. InChI, SMILES, and HELM are now supported in addition to CDXML.

We have added a new API to support updating the Status of a Synergy Experiment. Synergy experiments can be updated from Active to Submitted, Submitted to Closed, Submitted to Active, and from Closed to Submitted based on the “action’ specified in the request.

We have added an enhancement to our APIs to support closing of Work Orders. This is a new action, “approve_and_close” allowed when updating Work Orders via API and transitions a Work Order from Submitted to Closed.

We have enhanced the Work Order creation API to allow for specifying a template as part of the request. It should be noted that if the Work Order template includes a template for the Synergy Experiment associated with the Work Order it will not be automatically created. To achieve this, users should use the API to create the Synergy Experiment after successful creation of the Work Order.

Further Details

SAR & Decisioning

Quickly access published data without leaving the Material Library. The new Published Data tab automatically retrieves results for the selected material, displaying aggregated values by measurement type in a summary table. Interactive tables allow users to drill down to specific measurement results.

Admin Defined Tables, Variation Tables and Hierarchical Tables

Contextual Picklists now allow the use of Internal Reference properties as the source, including IDs from Sample, Task and Material tables, and Internal Search Attribute Lists.

Search is now enabled for Hierarchical Tables. Hierarchical Table is available as an option under the Type query tool. Additionally Hierarchical Table properties are available as individual query facets.

The data from Hierarchical Tables can also now be included in the Exported PDF as an attached .csv file.

Materials

A new set of calculated properties for protein complexes is available upon request for Custom and Protein material types and in the preconfigured Antibodies library. Molecular weight, isoelectric point, extinction coefficient, and total length can now be computed for complexes comprised of multiple protein parts linked to via internal references.

Up to 20 individual protein parts can be specified per calculation.

Updates to any of the underlying protein parts are automatically checked for when viewing the complex material.

Administration

Contextual Lists and Hierarchical Tables are now supported in both the Configuration Transfer process in addition to the new Configuration Report.

What’s New

We are delighted to release our new version of Signals, 26.4.

Fundamentals
– Ontologies integration allows terms to be used across experiments, materials, tables, and more available to all systems
– Ontology integration now supported in Synergy, including Collaboration, Idea, Work Order, and Synergy Experiments Templates, as well as Designs and Reference Table fields available to all systems
– CSV import handling for ontology terms
– Ontology support for plate templates
– External Ontology Sources now support SciBite CENtree
– Audit trail displays highlighted granular changes for text elements (beta)

AI
– Prompt-to-filter (beta)*
Data Workflows & Analytics*
– Data Assembly continuous viewer
– Median-based robust Normalizations
– Additional Quality Control metrics

SAR & Decisioning*
– Ontology support on Inventa Analysis templates
– New ChemCharts Biopolymer data functions
– ChemCharts Table usability improvements

Synergy^†
– Collaboration setting allows Sponsor admin to choose whether to use Material IDs or aliased ExIDs with CROs
– Search for Synergy Experiments based on Work Order
– System Snippets are available for CRO users
– Work Tasks in Work Orders (beta)
Chemistry
– Multi-strand and branched complex biopolymers now supported
– Upload of rdf file types to External Enumerator
Tables
– Definition and display of Scatter Plots on Admin Defined Tables available to all systems^*
– End user adjustment of Scatter Plots available to all systems^*
– Export of image from Scatter Plots available to all systems^*
– Highlight selected rows or points in the Scatter Plot and Table available to all systems^*
– Definition and display of Bar Charts on Admin Defined Tables^*
– Define and display Size By and Transparency on Scatter Plot to enable Bubble Charts on Admin Defined Tables^*
Inventory
– Enable container ID and barcode selection directly within Reagent tables
– Support Inventory Decrement at Sub‑Experiment Level in Parallel Experiments
– Display container details in Samples table when Material ID is present
– Multi Select property display in the Container search table
InventoryGo^‡
– Flexible reconciliation workflows introduced: Batch vs. Individual scanning options
Administration
– Migration for legacy Data Factory projects
– Spotfire for Signals Online Access privilege available
– Admin Defined Dashboards
– Audit trail displays highlighted granular changes for admin-defined tables (beta)
Integrations & Interfaces
– Ontology API Support
– Salt Stripping Data for Chemical Drawings fetch API
– Entity properties on Bulk Export API
– Update Hierarchical Tables Headers API
– External Enumerator via API
– Bulk create Samples via Summary Table via API

* Requires Signals One license
† Requires Signals Synergy license
‡ Requires InventoryGo license

We also fixed several small bugs in this release. Details of the enhancements are described below.

Administrators are recommended to subscribe to the channels within our support news site found at https://support.revvitysignals.com/hc/en-us/categories/360004446171-Support-News which contains more information about releases and other pertinent product information.

Data Factory administrators should be aware that the Bulk Delete option from the Inventa Dashboard is now available regardless of the “Enable system-generated Unique Result IDs in Spotfire workflows” setting. However, Using Bulk Delete still requires explicit mapping of a Unique Result ID.

Data Factory Administrators should note that legacy Data Factory projects will be fully deprecated in a future release. A straightforward migration path is now available to support this transition. A specific deadline has not yet been scheduled.

This content is anticipated for release on our Production E3 environments, and for Private Cloud customers on our deferred release schedule, in November 2026.

Further Details

Fundamentals

Ontology support is now available for all systems. Administrators may connect to a ontology provider (BioPortal, OLS, or SciBite CENtree) as an External Ontology. Once a specific ontology from that source is connected, Administrators can create a new type of Attribute, Ontology Lists, which contain a subset of terms from the ontology. This Ontology List can be used in templates and properties across signals, including Experiments, Materials, Tables, Samples, Admin Defined Objects, Plates, Inventa Analyses (for Signals One), Synergy Experiments and Design/Reference Tables, and more.

When you import a CSV into a table, ontology values are now validated against the Ontology List for that field. If a value in the CSV matches a term’s preferred name or any synonym, it is automatically mapped to the correct ontology term. If no matching term is found, users can resolve the value during import by selecting the appropriate term from the Ontology List.

Data Workflows & Analytics

In Signals One, all In Vitro Analysis users will discover that in the Data Assembly step, the 5-rows static preview has been replaced by an interactive viewer with continuous scroll. Numerical and categorical columns can now be filtered, sorted, reordered and hidden to flexibly slice and dice the data that will be used in the Analytics steps. Visual cues indicate the source data of the columns, and which columns were used during the matching process.

In the Analytics steps of the In Vitro Analysis, a couple of new normalization methods, using the median instead of the average, can now be found in the Inter Plate Method menu, both with the “Robust” prefix.

The Robust Normalized Percent Activation is calculated using the expression: “(value - median(n)) / (median(p) - median(n)) * 100” while the Robust Normalized Percent Inhibition is calculated using the expression: “(median(p) – value) / (median(p) - median(n)) * 100” (where p and n are the values for positive and negative controls). Median-based normalizations are called "Robust" because they are not heavily influenced by extreme outliers.

Finally, the mean and standard deviation of both positive and negative controls are calculated and added to the Normalization results.

SAR & Decisioning

ChemCharts Data Functions introduce Free‑Wilson analysis for HELM sequences, using aligned sequence and property data to quantify position‑specific monomer contributions. Combined with the Free‑Wilson Enumerator, users can design and prioritize novel HELM sequences based on predicted performance.

ChemCharts Table Visualizations now support a crosshair, which once activated highlights the cell, row number, and column header when moving the mouse.

Synergy

Synergy now allows the administrator to choose whether to use aliased ExIDs or Material IDs with a CRO on a Collaboration-by-Collaboration basis. An administrator with the privilege Manage Collaborations has access to a new Collaborations Settings menu on a Collaboration where the administrator can choose between aliased ExIDs or Material IDs. The default is ExIDs to support the current behavior. This setting can only be changed while the Collaboration is New (before being sent to the CRO) and no child Work Orders are yet created.

If the Collaboration is set to Materials IDs, materials shared via the Reference Table will display with their Material IDs to both the CRO and Sponsor. The Sponsor will not have a toggle to switch between the IDs, indicating that the Material ID will be shared with the CRO.

The use of Material IDs persists throughout the Collaboration in all child Work Orders and Synergy Experiments. For example, when a CRO user populates an internal reference column in an admin-defined table or when the Sponsor registers a Sample in a Samples table, the column will display the Material ID for both the Sponsor and CRO.

If the Collaboration is set to ExIDs (default), materials shared via the Reference Table will display with their ExIDs to the CRO, and the Sponsor will have a toggle to switch between the ExIDs, Material IDs, or both (existing behavior).

Both Sponsor and CRO users can now search for Synergy Experiments by the associated Work Order ID. The Work Order filter can be added in Advanced Search, typically alongside Type = Synergy Experiment, or to the Synergy Experiments Smart Folder.

Finally, CRO users can now access and insert System Snippets using the Insert Text Template on any Text element. Note, CRO users cannot save text templates to avoid cluttering the template options for all users.

Chemistry

The ChemDraw editor now supports rendering and cleanup of multi-strand and branched complex biopolymers, making these structures easier to display in a clear, aligned, and readable layout.

Users are now able to load an RDF type file into the External Enumerator for Parallel Experiment enumeration. Fields within the rdf can be mapped into the external enumerator. Reactant order is defined by the rdf file. Solvent and Rxn Conditions are not commonly included in the rdf file and therefore will need to be added manually.

Additional reactants or products can be added manually similarly to what can currently be managed.

Tables

Scatter Plots are now available to all tenants. End users require a Signals One license to view and edit charts in ADTs.

Configuration Administrators can now choose to define a Bar Chart on Admin Defined Tables. Similar to the definition of Scatter Plots, administrators can define the Bar Chart on the Table template including setting properties for the value and categorical axis. The chart can be a simple, stacked or 100% stacked bar chart and can be displayed vertically or horizontally. The admin can also choose if the end user is able to adjust the settings for the chart.

Configuration administrators can also now define a Size By and an Opacity setting for Scatter Charts. These two settings allow for the creation of Bubble Charts using the Scatter Chart type. If the end user is allowed to change chart settings these options are also available directly within the Admin Defined Table.

Inventory

Users with the right permissions can now assign or reassign containers in cloned or pre-defined experiments, even after container details are cleared, enabling more flexible and accurate inventory workflows in Reagent table.

Inventory Decrement can now be entered at the sub‑experiment level, allowing users to accurately update container usage when working with parallel, cloned, or reagent‑specific sub‑experiments.

Container details are now accessible from the Samples table even when a Material ID is provided, ensuring consistent visibility across sample workflows.

Container multi‑select properties are now available in the Container table, allowing users to view multi‑select container properties directly from the inventory view.

InventoryGo

A new Scan List mode has been added to reconciliation, allowing users to scan containers in bulk and fetch results on demand, with a toggle to switch between batch and individual scanning for more reliable and faster workflows.

Administration

A migration path for legacy Data Factory projects is now available. Legacy Data Factory will be deprecated in a future release; administrators are encouraged to migrate to the latest Data Factory as soon as possible. The Legacy Project Migration tool is available from System Settings > Other. Before migrating, review the Migration Guide within the Signals Configuration Guide.

Migration status and history are captured in the Migration Report.

After a successful migration, administrators can review the migrated project before committing the changes.

After you commit, the migrated project is ready to use and can be accessed from the Inventa Dashboard. The legacy project is no longer available for publication or data retrieval in Inventa.

Spotfire for Signals Online Access privilege available to control which users can access and substantiate Spotfire for Signals Online. Users without this privilege will be limited to Spotfire for Signals Analyst use.

Administrators should now be able to create and share dashboards from the SN Config. To edit, share or create dashboards, a user must have the “Manage Dashboards” privilege and access to the SN Config as Admin Defined Dashboards can only be edited or created within the SN Config.

The new “Dashboards” section can be found in the System Settings. To create a dashboard, the admin should select the green “Create Dashboard” button then they are prompted to enter a dashboard name and description.

When the admin clicks on “Create Dashboard” they will be brought to the Dashboard edit screen. Here they can add, remove, edit, or resize widgets similarly to what can be done with a personal Dashboard.

To add a new “Record List”, the most commonly utilized widget, the admin would select “Add Widget” > “Record List”. Under “List Source” the admin can select from a standard set of predefined lists or select “Define List” to create a new search list.

Selecting “Define List” > “Click to define query” brings up a search query builder the admin can utilize to define their search list.

Changes to the selected dashboard are saved by selecting the blue “Apply” in the top right corner.

The admin can then share the dashboard with other users or groups similarly to how sharing is managed in other elements.

Dashboards are automatically shared with Read access. If a dashboard is shared with write access or full control to a user or group that does not have access to the SN Config, they will be unable to edit or share the dashboard as shared dashboards are Read Only outside of the SN Config.

For end users, their current personal dashboard has now been named “My Dashboard” on the dashboard menu. Users are still able to edit their own “My Dashboard” as they were previously able to do. All shared dashboards appear below “My Dashboard”. If the user selects one of their shared dashboards this selection is sticky.

Integrations & Interfaces

We have added API support for writing to Ontology List fields. These are enhancements to all APIs which write to entities that support Ontology List fields and properties. There are new APIs to fetch and explore Ontology Lists. The “id” values found here are used to set values on Ontology List fields and properties.

We have enhanced the stoichiometry fetch API to include salt stripping data for a Chemical Drawing. This is a new URL parameter (includeStrippedData) which when true will include the stripped structure and the salts that were stripped from the Chemical Drawing as data in the response.

We have enhanced the API for bulk export of an entity to include the entities properties as part of the table of contents.

We have added a new API to allow patching of Hierarchical Table headers.

We have added new APIs to support the External Enumerator for Parallel Experiments. These APIs allow for usage of a csv or sdf file upload for use with the External Enumerator. There are APIs to fetch and update the mapping for the external enumerator. Lastly, there are APIs to kick off the enumeration and check its status.

We have added new APIs to support the bulk creation of Samples in a Parallel Experiment Summary table. This is an asynchronous job which has two endpoints, first to create the job and second to check the status. There is a URL parameter to support creating multiple samples per row. The request body allows for specifying specific rowIds to create samples from, defaulting to all rows. You may also optionally specify sample properties for all samples created as part of the request body.

Beta Features

The following capabilities are in beta and are available for users, administrators and developers on the Signals platform upon request. Please contact your account representative or our support team if you would like access to the following features.

Fundamentals

Audit trail displays highlighted granular changes within records for text elements in experiments and experiment-like objects. When users compare an audit record with a previous version, there is a "view granular changes" toggle. Selecting this toggle will show users a clear visual summary: gray highlighting shows text that was edited or removed and green highlighting shows newly added or updated text.

AI

We have added a new Beta AI feature allowing a user in Advanced Search to create a filter using a natural language prompt. This filter will be added on top of your existing filters unless the toggle to replace your existing query is enabled. This is limited to Signals One customers.

Synergy

Works Tasks can now be configured and added to Work Orders to create a series of trackable, assignable, and templateable sub-tasks for a Work Order. Work Task properties and templates can be configured in Synergy Configuration > Work Orders > Work Tasks.

A Sponsor user can add a Work Task to a Work Order when the Work Order is in an editable status (Draft, To Do, On Hold). The Sponsor can optionally specify a Synergy Experiment Template to be used for the Work Task, as well as specify which References the Work Task applies to.

Once a Work Order is sent, Work Task(s) Status changes from New to To Do. A CRO Department manager can optionally assign the Work Task(s) to a CRO user. A CRO user can start one or more Work Tasks by selecting the Work Task(s) and creating a New Experiment or adding the Work Task to an Existing Experiment. The Work Task(s) Status then changes from To Do to In Progress.

Note, when creating a New Experiment, the specified Synergy Experiment Template will be used when applicable. Also, each Work Task can have multiple Synergy Experiments associated, and additional Synergy Experiments can be added to an In Progress Work Task from the Work Task table in the Work Order.

Work Tasks display in a Work Tasks To Do table in each associated Synergy Experiment. When the task is done, the CRO user can Complete the Work Task. Work Task(s) must be Completed before submitting the Synergy Experiment.

Administration

Audit trail displays highlighted granular changes within audit records for admin-defined tables. When admins or users compare a table audit record with a previous version, there is a "View granular changes" option. Selecting this toggle will show users a clear visual summary: gray highlighting shows data that was edited or removed and green highlighting surrounding table cells reflects newly added data. Green highlighting with a dashed border reflects text that was updated.

What’s New

We are delighted to release our new version of Signals, 26.6.

Fundamentals
- Audit trail displays highlighted granular changes for text elements is available to all systems
- Audit trail displays highlighted granular changes for structured tables such as hierarchical tables, variations tables, materials tables, etc. (beta)
- Audit trail displays highlighted granular changes for worksheets (beta)
AI
- Semantic Search available to all systems*
Data Workflows & Analytics^*
- Administrative access to Signals Native Analytics is now available to all systems
- Curve fitting extended to Logistic regression 3-4-5 Parameters models is available to all systems
- Initial support for custom curve fit definitions and publication is available to all systems
SAR & Decisioning^*
- Receive an email notification when publication to Data Factory completes
- Track Data Factory publications with an “In Progress” status after submission
- View very small values in scientific notation in the Material Library’s Published Data section
- Use Insights to query, generate, and analyze Measurement and SAR Tables directly in Signals (beta)*
Synergy^†
- Administrative control of CRO privileges per CRO Department
- CRO privilege to enable Copy/Copy Partial of Synergy Experiments for CRO users
- Search Bookmarks in Synergy Advanced Search and Smart Folders for Sponsor and CRO
- File Upload in Synergy Experiments for CRO users
- Work Order-specific naming of Synergy Experiment Drafts
- Sponsor can Recall Work Orders in Accepted by CRO status
- Date Sent, Date Started, and Date Completed data on Work Tasks (beta)
- Configuration Transfer support for Work Tasks (beta)
Chemistry
- HELM string in the Products table and Sample
- Compact display option for Chemical Check Warning watermark
Tables
- Fill values in a column in an Admin Defined Table or Variation Table
- Fill values in a column in a Hierarchical Table*
- Disallow copy of values in a column when copying a row in an Admin Defined Table
- Disallow copy of values in a column when copying a row in a Hierarchical Table*
- Box Plots on Admin Defined Tables*
- Bucketed numerical column can be used for Categorical axis on a Bar Chart*
- Bar and Segment totals can be displayed in a Bar Chart*
- A Second categorical column can be displayed on a Bar Chart*
- Define segment ordering for stacked Bar Charts*
- Multiple lines per column in a Line Chart*
- Numerical properties displayed as aggregate on Y axes in a Line Chart*
Plates
- Increase of csv upload limit from 2000 to 50000
Inventory
- Bulk Update Home Locations for Containers
- Autofill for Inventory Decrement in Stoichiometry Table
- "Modified Date" and "Location Type" Column Added to Container Search Table and included in exported data
- New 54 × 25 mm (QR Code) Label Template with 5 Slots
InventoryGo ^‡
- Grid location support for Rectification workflow
- Activate/Deactivate default location for Auto Complete Rectification
- Optimized Adjustment Status Control
Materials
- UI update to material tables configuration available to all systems
Tasks and Requests
- Increase in Task creation limit from 2000 to 4000
Administration
- Audit trail displays highlighted granular changes for admin-defined tables is available to all systems
- A matching Configuration Report (PDF) generates based on selective configuration export (beta)
Integrations & APIs
- API Key Limit from 25 to 100
- API to export Monomer Library to JSON
- API to bulk export Containers
- Enhanced bulk Material Export to allow specifying materials
- APIs to fetch Report and Results tables from Data Exchange
- Fetch Synergy Data Exchange Report and Results Tables API
- Department assignment support via Bulk CRO User Update API

* Requires Signals One license

† Requires Signals Synergy license

‡ Requires InventoryGo license

The following OnDemand videos for Signals Synergy are now available:

Assays in Signals Synergy

Administrators should note that we have resolved an inconsistency in the way non global numbering currently works for Parallel Experiments, Requests, Inventa Analysis objects and In Vitro Analysis objects. These objects will now take the next number in sequence regardless of object type. The current behavior is that they take the next number in sequence for the given object type.

Data Factory Administrators should note that legacy Data Factory projects will be fully deprecated in a future release. A straightforward migration path will be provided in an upcoming release to support this transition.

Data Factory administrators should note there have been performance improvements for Bulk Delete and row-based publications.

This content is anticipated for release on our Production E3 environments, and for Private Cloud customers on our deferred release schedule, in November 2026.

Further Details

Fundamentals

Display of granular audit trail changes within text elements are now available to all systems.

AI

Semantic Search is now available to all systems

Data Workflows & Analytics

Administrative access to Signals Native Analytics is now available to all systems.

Analytics definitions for 3-4-5 Parameter logistic curve fittings are now available to all systems.

Custom curve fit definitions and publication is now available to all systems.

SAR & Decisioning

Users can now opt in to receive an email notification when a Data Factory publication or bulk delete action completes. The notification includes the target Project and, when available, the publication source. Multiple publication sources are supported including: Tables (e.g. ADTs), the Inventa Dashboard, and the Publish Results to Data Factory Spotfire app.

The Publication Report for Data Factory projects now displays an “In Progress” status after a publication is submitted, confirming that the request was received. The status updates when the publication completes.

The Material Library’s Published Data view now displays very small values in scientific notation in both Summarized and Measurement views.

Synergy

In Synergy, most CRO privileges are managed by CRO roles (CRO Department Manager vs Department Member), Collaboration access, and Work Order assignment. This keeps CRO onboarding and offboarding simple and CRO behavior predictable. However, some privileges require Sponsor administrative control. A Sponsor Administrator with the privilege to Manage CROs and access to CROs (System Administrators, Synergy Administrators and Synergy CRO Managers) can now manage CRO privileges in Synergy Configuration > Contract Research Organizations on a per CRO and per CRO department basis.

There are two administrator-controlled CRO privileges, Copy Entities and Copy Synergy Experiments. Copy Entities allows a CRO user to copy individual elements within Synergy Experiments, such as a Chemical Drawing, Text, or Table. Copy Synergy Experiments requires Copy Entities and allows a CRO user to Copy/Copy Partial a Synergy Experiment.

Search bookmarks allow the user to reuse common filters with a single click. In 26.5, we introduced search bookmarks in Smart Folders. In 26.6, we have extended search bookmarks to Synergy Smart Folders and Advanced Search for both the Sponsor and CRO. In a Smartfolder, a user can add a bookmark by selecting the bookmark Icon in the left corner. A specific Smartfolder will only show the bookmarks made with that Smarfolder, but all bookmarks are available in Advanced Search.

In Synergy Experiments, CRO users can drag and drop files files, such as PDFs, images, or documents. Now, CRO users have the option to File Upload under Add Content, allowing the CRO user to load multiple files at once.

When a Sponsor drafts a Synergy Experiment, the name is always appended with -draft. To provide additional differentiation for Draft Synergy Experiments and ensure Drafts do not consume a number in the Synergy Experiment auto-numbering sequences, Draft Synergy Experiments will be auto-named {Work Order name}-draft. If a Draft is deleted and replaced, subsequent drafts will be appended with a number independent of auto-numbering sequences (e.g., {Work Order name}-draft-1).

Finally, the Sponsor users can now Recall Work Orders in the status Accepted by CRO. Recalling a Work Order requires Full Control (e.g., authorship or via shared access) to the Work Order. As with Recall on To Do Work Orders, recalling a Work Order removes it from the CRO and returns it to the editable Draft status for the Sponsor.

Chemistry

Admins can now add the HELM string as a chemically aware column in the stoich grid. The admin can add a new variable property to the Reactants and/or Products table of the stoich grid. Under variable property is the new HELM String option. This property can only be used once in the table.

This HELM String property will update as the HELM structure is updated.

The HELM property is also available in the Sample. Admins can add the property by selecting the field type Calculated Property > HELM String. As with the Stoich property, this option can only be used once.

The HELM String property will also be available in the Chemistry autotext as is currently possible with all other stoich properties.

Admins can now utilize a compact view of the chemical check warning. This is especially useful for users working with larger molecule and HELM representations. The compact view can be enabled in the External Checking section of the Chemistry Settings. This is a tenant-wide setting.

The compact warning display is smaller and placed near the top of the canvas to be less obstructive of the chemistry.

Tables

Admin Defined Tables, Variation Tables and Hierarchical Tables now allow users to right-click and fill a given cell value into other rows. The user can select if they Fill Up (all rows above), Fill Down (all rows below) or Fill All. If the user has selected rows they can also fill the selected rows only.

Configuration Administrators can also set that the values in certain columns in Admin Defined Tables and Hierarchical Tables are not copied if a user copies a row.

Configuration Administrators can now choose to define a Box Plots on Admin Defined Tables. Similar to the definition of other chart types, administrators can define the Box Plot on the Table template including setting properties for the Categorical and Numeric axes. The admin can also choose if the end user is able to adjust the settings for the chart.

Configuration Admins can now also define numerical values on the categorical axis of barcharts. Admins define a number of buckets for the numerical values to be segmented into. Admins can also define that bar and/or segment values are displayed on the chart.

A second categorical property can also be used to display on the categorical axis to allow a side by side vs a stacked bar chart.

The Configuration Admin can also define either an ordering for the segments in a stacked barchart, either by name or by value.

Setting a Color By allows plotting of a single column of data in a Line Chart as multiple lines.

An aggregate method can also be defined for the Numerical properties plotted on Y and Secondary Y axes of a Line Chart.

Plates

The csv upload maximum has been increased from 2000 rows to 50000 rows to better accommodate multiple large plates. Larger files may take some time to upload.

Inventory

Users can now update the home location for multiple containers at once from the Container Search Table. After selecting containers and choosing Edit Home Location, users can either set the current location as the home location or assign a specific grid or non-grid location using barcode scanning or location search. The operation supports partial success handling, provides a downloadable CSV report containing the Container ID, previous home location, and new home location, and records all changes in the audit trail.

The Reactants grid now includes a user-triggered Autofill feature for the Inventory Decrement column. Users can bulk-populate all rows via a header-level Autofill button or update individual rows using a row-level option. The system automatically maps the correct source value based on container unit: Sample Mass for mass-based containers and Volume for volume-based containers. Manually entered values are never overwritten, and containers in Disposed, Final Disposed, or Trashed status are excluded. Clear success/error feedback is provided, with row-specific error icons on hover for troubleshooting.

The Container Search Table now includes additional reporting and filtering capabilities with support for both Modified Date and Location Type columns. Users can view, show/hide, filter, sort, and export these fields to quickly identify recently updated containers or locate containers stored in specific location types (such as refrigerators or acid cabinets). Both columns support header-level filtering, are included in CSV/Excel exports (and SDF exports for Modified Date), and enable more efficient reporting, auditing, and offline analysis.

A new label template sized 54 × 25 mm is now available for container barcode printing. The label features a QR code along with 5 configurable slots that Admins can map to any container or material property via SN Config. Long location paths are intelligently truncated — displaying from the closest location upward and trimming the beginning if the path exceeds the available space.

InventoryGo

Users can now rectify inventory discrepancies involving containers stored in grid locations. The Rectification workflow has been enhanced to support grid-based storage, allowing users to accurately select and update container locations within specific grid cells during reconciliation activities. This improvement streamlines inventory correction processes, improves location accuracy, and ensures grid location assignments are maintained consistently throughout the rectification workflow.

The Adjustment Status control in InventoryGo has been redesigned to improve usability on smaller mobile screens. The previous button bar has been replaced with a compact ellipsis menu, reducing screen clutter and allowing more container information to be displayed without scrolling. Users can still access all adjustment actions while benefiting from a cleaner, more space-efficient interface.

Users can now control whether a location is used as the default location for Auto Complete Rectification by activating or deactivating the setting directly on the location record. This enhancement provides greater flexibility when managing reconciliation workflows, ensuring that only appropriate locations are automatically selected during rectification. By allowing administrators to enable or disable this behavior as needed, organizations can better align auto-completion processes with their inventory management practices and location usage policies.

Materials

The user interface for Admin configuration for materials tables in Signals Configuration has been updated and is now available to all systems.

Tasks and Requests

The maximum number of tasks has been increased from 2000 to 4000 to better accommodate workflows that require multiple tasks per sample.

Administration

Display of granular audit trail changes within text elements are now available to all systems.

Integrations & APIs

We have increased the API key limit from 25 to 100.

We have added API support for exporting individual monomer libraries to JSON.

We have added a new set of asynchronous APIs to bulk export containers as either a csv or sdf file, defaulting to csv. This follows our standard pattern for asynchronous APIs of start job, check status, and download the content. You may optionally specify a list of container barcodes to export; if not provided, it will export all containers, up to 600,000. Optionally, you may also include filters to only return containers which match the filters. 'Container Type', 'Status', 'Location', 'Content Entity Type' and 'Material Library' are currently supported filters. Lastly, you must include the set of fields, with a minimum of one, to include in the export. Barcodes, fields, and filters are all specified in the request body to initiate the export job. See the Swagger page for full details and examples.

We have enhanced existing APIs for bulk exporting material libraries. You may now specify a list of materials, by ID, to export in the request body. If not provided, the entire library will be exported.

We have added a new set of APIs for our Synergy product to fetch the list of Data Exchange files, the data exchange report file, and the Data Exchange results table file by table name.

We have enhanced the bulk update for CRO users to include updating Departments when including them in a column in the bulk update csv.

Beta Features

Fundamentals

Audit trail displays highlighted granular changes for structured tables and worksheets. The structured tables included are the following: variation tables, hierarchical tables, samples tables, materials tables, task tables, work tasks, design tables, synergy experiment tables, & sample tables. When users compare an audit record with a previous version, there is a "view granular changes" toggle. Selecting this toggle will show users a clear visual summary: gray highlighting shows text that was edited or removed, green highlighting shows newly added, and dashed boarder green highlighting indicates updated text (beta).

SAR & Decisioning

Insights is a new Signals object (beta) that lets users query Data Factory and generate summary or SAR tables directly in Signals. After an Administrator enables the feature, users can create Insights from the Add New menu or the dedicated Smart Folder.

When creating an Insight, users define a Data Factory query by specifying criteria for materials, measurements, or both.

Running the query automatically generates an aggregated summary table, or SAR table, based on the selected criteria. Users can configure the table by renaming columns, controlling numeric display, adding secondary values within cells such as count, applying color options, filtering, and sorting. Some field types, including Chemical Structures, include additional formatting capabilities, such as chemical fragment highlighting. Column settings are available by right clicking the column header.

After a query completes, Insights returns a broad set of columns. Users can choose which columns to display from the Column Selector under Show more > More Options, using search and aggregation-type filters to find the most relevant columns.

Configuration changes are automatically saved to each user’s personal view and persist locally in the browser. Users with Write access to the Insight can save their personal view (“My View”) as the Default view for all users, supporting a consistent shared layout while preserving individual flexibility.

From a summary or SAR table, users can right-click any cell to add the corresponding Measurement table containing the individual rows behind the aggregated result. If the measurement type has an associated Details measurement type, it is retrieved automatically. An Insight can include multiple Measurement tables for different measurement types.

Synergy

As part of the existing Synergy Work Tasks beta feature, Work Tasks have several new properties. Sponsors often want to track how long it takes a CRO or CRO Department to perform certain tasks. Thus, Work Tasks now track the date/time the Work Task was sent (Date Sent), started by the CRO (Date Started), and completed by the CRO (Date Completed). These properties are visible on the Work Task, via search, and via API.

Finally, Work Tasks properties and templates are now supported in Configuration Transfer.

Administration

A matching Configuration Report (PDF) generates based on the selective configuration export. When users select specific objects to export during configuration migration, a matching Configuration PDF Report will generate in an export modal based on the object selections made (beta).

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