Revvity Signals Research Suite - 2023 Updates

The Signals Research Suite is a complete, integrated data capture, processing & analysis SaaS software for scientific research. Capture, manage, and share experiment data, notes and research findings in a secure and accessible environment built on the foundation of Signals Research Platform.

Releases By Year

2024 2022 2021 2020

23.10 Nov 2023 (Update to E3 in March 2024)

What's New

Revvity Signals™ Research Suite, including Signals Notebook

This version 23.10 release of Signals brings the ability to synchronize custom material libraries to Signals Inventa. We have also made a number of improvements to Inventory, added locking to embedded Tables in Worksheets, improved the process for adding multiple Internal References, enhanced our Materials Libraries and extended our External APIs. We have continued to work on our ongoing beta capabilities for HELM monomers. Finally, we have also fixed a number of small bugs.

The following improvements are available for users of Signals Notebook Individual Edition, Signals Notebook Standard, Signals Notebook Private Cloud, Signals Research Suite Standard and Signals Research Suite Private Cloud. Certain features may only be available with appropriate licensing and/or with enablement by an administrator.

•    Fundamentals
–    Type or paste of internal references (beta)

•    Inventa
–    Sync custom Material Libraries
–    Out-of-the-box maps for Material Libraries

•    Worksheets
–    Embedded Admin Defined Tables can be locked after editing and require a Reason for Change to be further edited

•    Inventory
–    Tooltip for on-the-fly Container amount calculation to US units
–    Admin option to enable/disable US unit calculations
–    New Label Templates for Containers
–    Location Grid Coordinates shown for all Locations Paths
–    Container Search Table (beta)

•    Materials
–    Bulk export Materials as a .zip archive
–    Bulk update of Sequence Materials
–    None option for Pictogram, Hazard, and Precautionary Statements

•   Administration
–    Unlock locked users in Signals Authentication
–    File download of file versions from the audit log
–    Configuration Transfer of HELM Monomer library (beta)

•    Integrations & APIs
–    Locked Admin Defined Tables in Worksheets can be patched with a reason for change
–    API support for bulk import of RNA Materials.
–    API support to bulk export chemically aware libraries in additional formats
–    API support to retrieve HELM Monomer libraries

We also fixed several small bugs in this release. Details of the enhancements are described below:

Administrators should note that certain of our operational URLs will be changing as part of our rebranding effort from PE to Revvity If you currently whitelist our operational URLs you will need to add the new URLs in order to continue unrestricted access to the application. If you do not whitelist our operational URLs then you can ignore this message. Specifically, if you have whitelisted “login.snb.PE.com” you should add “login.srp.revvitycloud.com”. Also, if you have whitelisted webdav.*, for example “webdav.signalsnotebook.PE.cloud” you should add webdav.signalsresearch.revvitycloud.com”. Additionally, if you have whitelisted incoming emails from the application, please also add noreply-srs@revvitycloud.com or just revvitycloud.com to your whitelist. Further information on whitelisting operational URLs can be found here: https://support.revvitysignals.com/hc/en-us/articles/4408240261012-How-to-access-Signals-Notebook-from-closed-network-

Administrators and users are reminded that we are beginning to transition to new URLs for accessing the application with this release. We will be adding the new access URLs shortly after the release and removing the original URLs at the end of March. We encourage you to update relevant bookmarks and start using the new URLs as soon as they become available. Further information on the ongoing changes to our URLs and the potential actions you may need to take can be found here: https://support.revvitysignals.com/hc/en-us/articles/20264670846740-Signals-Notebook-Upcoming-domain-changes

Developers should note that we will be changing the GET/entities endpoint to exclude Trashed Items by default. The "includeOptions" will now default to "untrashed" when no explicit parameters are specified. To get the current pre-change behavior you can include "trashed,untrashed" as the "includeOptions". This will not impact users who are already specifying specific "includeOptions" as part of their usage of the endpoint. This change will occur in a future release.

Administrators are recommended to subscribe to the channels within our support news site found at https://support.revvitysignals.com/hc/en-us/categories/360004446171-Support-News which contains more information about releases and other pertinent product information.

This content is anticipated for release on our Production E3 environments, and for Private Cloud customers on our deferred release schedule, in March 2024.

Further Details

Inventa

Custom material libraries can now be synced to Inventa in Signals Research Suite tenants. As a reminder, only 1 library can be selected for the Material Sync.

Example Inventa maps for out-of-the-box material libraries (Antibody, Cell Line, Compound, Plasmid, Reagent) are now available from the Help Center.

Worksheets

Embedded Tables in Worksheets can now be set to be locked once edited. The “Lock field after value has been entered” setting is now available on Table type properties when defining the Worksheet. Once selected, a table will become locked to further editing once it contains data and the user has stopped editing it. In order to make further edits the user must unlock the table, those edits are not saved until the user completes the Reason For Change workflow.

Inventory

A new tooltip for on-the-fly Container amount calculation to US units is now available in inventory. The tooltip automatically converts the SI amount into a fixed set of US units as follows:

This tooltip is currently only available for Container Amounts and not the Total Container amount value.
This tooltip and the associated US unit converter on container creation are now controlled by an Admin option to enable/disable US unit calculations.

We have added two new label sizes with QR codes and pictograms, for Containers: 50 x 50 mm and 101 x 50 mm.

Location Grid Coordinates will also now show for all Location Paths.

If the path is too long, the coordinate will show in the hover over.

Materials

Materials can now be exported as a Zip archive. This archive will include file attachments and images for the selected Materials.

Sequence based Materials may include sequence files in a bulk update. A supported file type should be included in the upload. Users will see new examples and scenarios of how the system will handle sequence file types uploaded to a given target Material collection.

“None” is now an option for Pictograms, Hazard, and Precautionary Statements to make the safety information more accurate in Material Libraries.

Administration

If an end user attempts to log into Signals Notebook multiple times using an incorrect password, their user account in the Signals Authentication service can become blocked. If this happens, administrators can force the unblocking rather than waiting for the block to be removed. The unblock option is available from the user screen.

File changes in the audit log are now available for download. For example, if a Sequence based Material file is updated, both the current and previous version are available for download from the system.

Integrations & API's

Endpoints for editing ADTs have been enhanced to support the locking of ADTs embedded in Worksheets to ensure that a reason is entered for any change on a locked table. The PATCH/adt/{eid}, POST/adt/{eid}, PATCH/adt/{eid}/{rowid}, and DELETE/adt/{eid}/{rowid} endpoints have been enhanced to allow for a valid reason for change to be entered via a “meta” field when a locked table is being edited.

The Materials bulk import API now supports import of RNA Materials. An example zip file can be downloaded with the GET API "/materials/{libraryName}/bulkImport/example" endpoint.

The POST /materials/{libraryName}/bulkExport endpoint now supports exporting chemistry type Materials via a CSV in SMILES, InChI, or HELM formats.

A new endpoint is available to fetch the configuration of all active HELM Monomer Libraries. Note that this endpoint will not be usable without activation of the Monomer Library beta capability.

The following capabilities are in beta and are only available to users and administrators of Signals Notebook Standard, Signals Notebook Private Cloud, Signals Research Suite Standard and Signals Research Suite Private Cloud upon request. Please contact your account representative or our support team if you would like access to the following features. They are unavailable as part of Signals Notebook Individual Edition.

Fundamentals

Internal references can be typed or pasted into tables. If the value is unique and matches an admin defined query, it will convert to a valid link with preview options available. Users may paste across and down columns and paste actions can include multiple values. Users will see error messages if an internal reference cannot be mapped as typed or pasted. For paste actions with multiple internal references, the operation will fail if any of the pasted values are invalid, and a warning will be displayed. Users can still enter internal references using the search icon in each table cell.

Inventory

We have added a new page to show containers available in Inventory. This can be found by clicking the bottle icon at the top of the page.

To change the headers in the table, click the Show/Hide Properties to deselect the unwanted properties.

To filter the containers to Samples, Material Libraries with Batches/Lots or Material Libraries with only assets select the corresponding checkbox.

You can further filter containers based on Material Library.

You can also adjust headers based on the available properties from the selected Material Libraries.

To see containers for multiple types at once check multiple boxes (ex: Samples and Material Libraries with Batches/Lots).

Administration

HELM Monomer Libraries configuration may now be included in a configuration transfer file. The libraries as well as the search order of the libraries in the source tenant may be selected for transfer to the destination tenant. Transfer of the monomers in each library should be conducted via the HELM Monomer Curation App.

23.9 Oct 2023 (Update to E3 in March 2024)

What's New

Revvity Signals™ Research Suite, including Signals Notebook

This version 23.9 release of Signals brings improvements to our Inventory and Materials management to be able to switch containers in Materials Tables, additional filters for Containers and support for RNA in Materials Libraries. We have enhanced our Calculations Explorer for VitroVivo and enhanced our chemistry viewer to allow users to zoom into smaller content when the chemistry is in read-only. We have added beta capabilities around Plates for autolayout and creating Plate templates. Finally, we have also fixed a number of small bugs.

The following improvements are available for users of Signals Notebook Individual Edition, Signals Notebook Standard, Signals Notebook Private Cloud, Signals Research Suite Standard and Signals Research Suite Private Cloud. Certain features may only be available with appropriate licensing and/or with enablement by an administrator.

VitroVivo
–    Updated Calculations Explorer templates available in out of the box workflows to new layout
–    Calculations Explorer UX improvements: details tab is now “read-only” and ambiguous toggles in dialogs have been replaced by consistent check marks
–    Removed pipelining feature not available in SaaS

Inventa
–    Material Sync connection is now automatically enabled

Chemistry
–    Zoom in/out for non-editable ChemDraw Documents
–    Calculation of mass of Solvent in the Solvents Table

Materials Tables
–    Switch Containers

Plates
–    Plate Autolayout (Beta)
–    Plate Templates (Beta)

Inventory
–    Move Location Notification
–    CAS and Contents name Filter

Materials
–    RNA Materials
–    Bulk download of biological sequence files available to all systems

Administration
–    Materials Library administrator can add and edit Attribute Lists in Materials without Manage Attributes privilege

Integrations & APIs
–    Identify that an ADT or Worksheet did not use the latest version of the template
–    New endpoint for searching containers by barcodes

We also fixed several small bugs in this release. Details of the enhancements are described below:

End users and Administrators should note that we will soon start changing the URLs used to access Signals Notebook and Signals Research Suite. The existing URLs will be supported during the transition period. We will be posting more detailed information at https://support.revvitysignals.com/hc/en-us/articles/20264670846740-Signals-Notebook-Upcoming-domain-changes and all are encouraged to monitor for any changing information at that site.

This content is anticipated for release on our Production E3 environments, and for Private Cloud customers on our deferred release schedule, in March 2024.

Further Details

VitroVivo

In the Calculations Explorer, the details tab is now “read-only”, with fields like Name or Description (left) being displayed without being editable, since editing is natively provided by Spotfire (right):

The ambiguous toggles to create a Calculations Explorer template have been replaced by check marks:

Finally, the features related to Pipelining, not supported in SaaS, are no longer available.

Inventa

Administrators can now select which material library to sync with Signals Inventa in the Signals Research Suite. Previously, only the Compound library was supported. We’ve expanded the supported libraries to included: Antibodies, Plasmids, Cell Lines, and Reagents. Please note that only a single library may be synced at a time. This enhancement is only available for Signals Research Suite tenants.

The synchronization between a Material Library and Inventa is now automatically enabled for all Signals Research Suite tenants. The “Signals Inventa Integration” and “Signals Notebook Connection” screens have been removed. To start a sync, admins need only to choose a supported Material Library and prepare the map and schedule.

Chemistry

ChemDraw Documents that are not editable now allow a user to zoom in and out to aid in seeing smaller content. The zoom buttons appear in the bottom left corner of the ChemDraw canvas.

Users can now calculate the mass of a solvent in the Solvent table automatically using the Density and Volume values.

Materials Tables

Users can now switch containers from within the Materials Table.

Additional containers of the same material lot/batch will display:

If an amount is entered into the Inventory Decrement column users will need to confirm before switching the container that they want to remove the amount from the old container:

Inventory

When users move the contents of a location, they will now receive a notification under the bell icon when the move is complete.

Opening the notification will allow the user to download or navigate to the Inventory Bulk Results page:

New filters for CAS and Contents Name (Contents of a container) are now on the Browse Inventory Home Page as well as the Location page, Container tab:

Users can choose to enter 1 or more CAS numbers to filter results:

Or users can enter 1 or more Contents Names to filter results:

Materials

Administrators may now configure RNA Material types. Like other sequence-based Materials, administrators may designate if a file is required or optional for registration. RNA Material type must be selected at the start of creating a new Material.

File types supported include FASTA, GenBank, and SnapGene RNA files. RNA Materials will be displayed as single-stranded and linear unless the file specifies otherwise. For an individual sequence registration, if the uploaded file does not contain an RNA string the system will prompt the user to proceed or cancel. If the user proceeds the system will convert the string. DNA strings will be converted to RNA and FASTA protein strings will be converted to ambiguous RNA strings. The same actions will occur for bulk RNA Material uploads automatically. The original file used to create any RNA material will remain unchanged and available for download from the system.

Bulk sequence downloads are available to all systems. When exporting DNA, RNA, or Protein materials the user can choose from a variety of formats for sequence retrieval.

Administration

Lower-level Administrators can now add and edit properties of type Attribute List to Materials Libraries without the Manage Attribute privilege. Users with Configure System and Manage Material Libraries privileges can now create or edit existing properties of Material Libraries of type Attribute List. They can only select Attribute Lists that are unsecured or that they have a Group Association to.

Integrations & API's

The GET /entities/{eid} has been enhanced for Admin Defined Tables and Worksheets to track if their related system template has changed. This new flag/value, “hasTemplateChanged”, will only appear, with a value of “true”, if the template the ADT or Worksheet being queried has changed and will not be included at all if it has not.

Additionally, we have added a new endpoint: POST /inventory/containers/search. This new endpoint allows you to search for inventory via barcodes. You may specify up to 100 barcodes in your query. Results will ignore disposed and deleted containers.

Plates (beta)

Users can now generate a plate map more efficiently when laying out multiple samples. Users can select the samples they wish to plate, plan their plate order, designate a starting position, and conveniently add these samples to the plate. Additionally, this enhanced functionality automatically updates plate annotation layers with sample metadata.

In addition, plates are now a part of Systems Object in the Signals Configuration Application. Administrators can now create plate templates with pre-defined annotation layers using the new Plate Template feature.

Users can now choose from a selection of plate templates available to them when creating new plates for their experiments.

23.8 Sep 2023 (Update to E3 in March 2024)

What's New

This version 23.8 release of Signals brings improvements to VitroVivo, Inventa, updates to the ability to move locations in Inventory, some additional calculations in ADTs, an ability to see when ADT and Worksheet templates are not the most current. Administrators can now control who can execute certain signing workflows, and lower level admins can better configure various templates. We have added more improvements around administration, molecular sequences, inventory and beyond, and provided a beta capability around the bulk download of molecular sequence files. Finally, we have also fixed a number of small bugs.

Fundamentals
– Copy/Paste Image into a Text element

VitroVivo
– Updated description of the 4P and 3P curve fits
– Removed Pipelining workflow from Workflows tab
– Deprecating Hierarchical view in Calculations Explorer
– Faster calculations for SPR Referencing
– Improved user interface for In Vivo Apps
– Sequence File Generator App: Group label based selection of Standard Curves and Quality Control samples

Inventa
– Select a different material library for synchronization (Compounds, Antibodies, Plasmids, Cell Lines, or Reagents)
– BLAST support in Global Search

Biological sequences
– Support for RNA sequences

Chemistry
– Single click canvas expansion
– Addition of mL/g and density to Solvent table

Admin Defined Tables
– Identify and update when a Table is using an obsolete definition
– Sum Over, Average Over, Standard Deviation Over, If type calculations

Worksheets
– Identify and update when a Worksheet is using an obsolete definition

Inventory
– US Unit entry aide in Inventory container Amounts
– Container search, link, and decrement from Materials Tables available to all systems
– Updates to move location contents
– Divide Inventory App privilege

Materials
– Bulk download of biological sequence files (beta)

Administration
– Force creation of user in Signals Authentication Service
– Configuration administrator can add and edit Attribute Lists in templates without Manage Attributes privilege
– Workflow Privileges

Integrations & APIs
– Update to POST /inventory/containers and POST /inventory/containers/

Administrators should note that the Inventory App privilege is now divided into 2 privileges, Inventory App is for all users of Inventory and Manage Inventory is for Inventory managers. Administrators should add the Manage Inventory privilege to roles that need to create container and location types instead of the Manage System Templates.

Administrators should note that in this release we will be updating Signals Inventory to no longer allow renaming of Locations. We suggest administrators create new locations and move the contents from the previous location to the new location and then delete the unwanted location. This update will also include the use of external APIs. Administrators should update scripts to no longer rename Locations through the external APIs.

Administrators are recommended to subscribe to the channels within our support news site which contains more information about releases and other pertinent product information.

This content is anticipated for release on our Production E3 environments, and for Private Cloud customers on our deferred release schedule, in March 2024.

Further Details

Fundamentals

Users will now be able to insert images into the text element using Copy/Paste. As with the existing Image insert functionality, the size is limited. Images less than 500 kb will be inserted in-line into the text element. Copy/Pasting larger images will automatically create an image element. This behavior is consistent with the existing “Insert Image” option available in the text element.

VitroVivo

The naming of the parameters in the 4 Parameter and 3 Parameter curve fits is now consistent with the equation displayed in the Calculations Explorer.

The Workflows tab does not contain a Pipelining QA-QC workflow anymore, since this capability is not yet available in SaaS.

The Hierarchical view, in the Calculations Explorer, was confusing for our customers and has now been deprecated. When running the Calculations Explorer using old templates created in Hierarchical view, a warning now indicates to the user that the template can be executed but not modified or saved in that modality anymore (the Update button remains inactive). The more flexible open page layout view, preferred by our users community, is now the default.

The SPR Referencing App now has increased performance allowing faster data processing.

In Vivo apps will now show the different built-in steps in a vertical layout. These enhancements apply to the following apps: Study Designer, Dose Preparation and Baseline Capture.

Previously, users were unable to distinguish between various standard curves or different quality control samples when creating the sample run list using the Sequence File Generator App. Now, users can assign unique group labels to their standard curves or quality control samples and the app will allow them to select these samples based on their assigned group labels. Moreover, the app will automatically generate unique sample names by appending the corresponding group label to each sample.

Inventa

Global Search now supports protein and nucleotide BLAST queries. Attributes defined as “Bio Sequence” in Signals Data Factory will have two new options in Global Search, “BLAST” and “Has Exact Substring”. Each option will return a new Sequence Query summary table that displays either sequence alignment information or highlighted substring matches.

Biological Sequences

Users may now upload RNA sequence files to experiments. An RNA based sequence file can be added via the Biological Sequence Element or drag-and-drop actions. Supported RNA file types are GenBank, FASTA, and the SnapGene (.rna) formats. The sequence will display as a linear single strand, unless otherwise specified in the file metadata. Properties and the underlying sequence are available for search.

Chemistry

Users now have a single click option to expand the ChemDraw canvas to maximum size in experiments. If the stoichiometry table is open when this option is clicked, it will be positioned at the bottom of the screen and available by scrolling. In the expanded view there is also an option to quickly collapse the canvas to return to the experiment overview.

Two additional fields have been added to the Solvent table to more closely mirror the solvent functionality currently available in the Reactants Table. The new mL/g calculation is the “Amount Ratio” of the mass of the limiting reagent to the volume of a specific solvent. Users are able to enter a ratio for this new column and a Solvent volume will be calculated.

The density for the solvents available in the solvent list is now displayed in the solvent table as is currently possible for Solvents added to the Reactants table.

Admin Defined Tables

The administrator can now add instructional text to the Headers and Column Headers for Admin Defined Tables. This text is displayed to the end user via a tooltip.

Additional calculations have been added to the supported equations in Admin Defined Tables. The equations now support SUMOVER, AVGOVER and STDOVER. These equations follow a format such as SUMOVER (Arg1, Arg2) where a numerical column can be calculated as the Sum, Average or Standard Deviation of another numeric column (Arg1) where a third column (Arg3) has identical values.

The equations also support an IF statement. These equations follow a format such as IF (Arg1, Arg2, Arg3) where Arg1 sets up an expression, and Arg2 is entered for the row if the expression holds true, and Arg3 if not.

Worksheets

Worksheets added by an author will now show a warning if the worksheet definition used is older than the most recent version defined by the administrator. The author can then update to the most recent definition, note that any data entered into the worksheet will be lost when they update the definition.

Inventory

A new value entry aide has been added to the Amount field on Container creation to allow users to enter amount values in US units and have that value automatically converted for storage and later use in inventory. Users just need to select the new calculator icon beside the “Amount” field on the container creation modal. This expands the converter where users can enter a value, select the US unit, and the amount is automatically converted to the corresponding Scientific unit in the Amount field.

The value stored in the Amount field is what will be stored on the backend and utilized for amount decrements.

The Container search, link, and decrement from Materials Table capability is available to all systems.

We have improved the move location workflow and will now show the percent complete of the move request in the toast as well as in the Inventory Bulk Results page:

If a move request is in the “Pending” status, a Cancel option will appear and the move request can be removed from the queue:

We have changed the existing Inventory App privilege to provide access to the end user interface for viewing, creating, and editing Containers and Locations. We have added a new privilege, Manage Inventory, for Inventory Administrators to be able to View, Edit, Create and Delete Container and Location types, and Label templates:

Administration

Administrators can now force the creation of users in the Signals Authentication service if they do not exist. If the user is not created in the Authentication service, the admin will be shown an option to add them in the user view. The option will not be displayed if the user already exists.

Non system administrators can now add and edit properties of type Attribute List in various templates including Experiment properties, Admin Defined Tables and Worksheets. Administrators no longer require the Manage Attributes privilege, instead an administrator with Configure System and Manage System Templates will be able to add and edit Attribute Lists that the have access to, either unsecured lists or those where they have a Group Association to at least one value. In the case of Experiment properties the admin will only be able to select a default value for those values they have access to.

Administrators will now be able to customize which users have access to which object signing workflows based on a combination of the existing Workflow settings and a new set of privileges.

For a user to see the option in their signing page, both the workflow setting and the privilege will need to be enabled. In the example below even though the “Allow Void” workflow setting is available, the user does not have the “Allow Void” privilege and so does not have access in the signing page.

Integrations & API's

The POST /inventory/containers and POST /inventory/containers/bulk have been enhanced to allow for the creation of containers for Asset Only Materials. Previously, via the API, containers were restricted to only those in Samples or Batches.

Additionally, we have added additional data validation to the API to ensure only expected values are allowed when using POST/PATCH endpoints.

Materials

Users have expanded options for export of Materials that are of type Protein or DNA. Users with the ability to export materials still first choose the export option under the Action menu.

A modal will open presenting the user with a several export options. The user may choose to obtain a download with the original sequence files or to retrieve the sequences as a multipart GenBank or FASTA file. The CSV download option will still only retrieve the Material properties and not include sequence data. When exporting by ID, the user will be presented with the same modal to choose the format of the sequence based material export.

23.7 Aug 2023 (Update to E3 in November 2023)

What's New

This version 23.7 release of Signals brings improvements to our materials handling with improved bulk upload and update mechanisms, the ability to move location contents, adding single stranded DNA support for biological sequences, enhanced some VitroVivo workflows and a new monomer curation app, available under beta on request. We have also improved some capabilities targeted for our regulated users by adding a more in depth History view for Plates and making the capability to embed tables in Worksheets available to all systems. We have also made some fundamental usability enhancements and improved administrative and integration capabilities. Finally, we have also fixed a number of small bugs.

Fundamentals

–Downsizing of large images

VitroVivo

–Sequence File Generator App ability to add replicates to the sample run list

–SPR Zeroing App performance improvements and now using the Apps SDK

Biological sequences

–Support for Single-stranded DNA

Chemistry

–Remember prior criteria in QuickAdd search window

–HELM Monomer Curation Application (beta

Admin Defined Tables

–Administrator can define instructional text for Headers and Columns

–Log, Natural Log and Exponent calculations

Worksheets

–Embedded Admin Defined Tables available to all systems

–Printing of embedded Admin Defined Tables

Plates

–Compare versions of Plates History

Inventory

–Move location contents

Materials

–Bulk update of chemical Materials with SMILES, InChI, or HELM (beta)

–Bulk upload of HELM Materials (beta)

Administration

–Improved display of items with collapsed partial selections below in Configuration Transfer

–Update of stoichiometry definition in ChemDraw documents in System Templates

–Privileges to manage HELM Monomer Libraries (beta)

Integrations & APIs

–Enhanced POST/entities to allow creation of Tasks

–Container and Location Attachment fields can be added, updated and deleted

We also fixed several small bugs in this release. Details of the enhancements are described below:

Administrators should note that in this release we will be updating the Concentration field in the Materials Library and Variable Measures using the measure called “Count” to be a COUNT measure instead of an INTEGER. The entered values will not be affected. Any use of the external APIs using this field may need to be updated appropriately.

Administrators should note that in an upcoming release the Inventory App privilege will be divided into 2 privileges. Inventory App which will be for all users of Inventory and Manage Inventory which will be for Inventory managers. Administrators will need to add the Manage Inventory privilege to roles that need to create container and location types instead of the Manage System Templates.

Administrators are recommended to subscribe to the channels within our support news site which contains more information about releases and other pertinent product information.

This content is anticipated for release on our Production E3 environments, and for Private Cloud customers on our deferred release schedule, in November 2023.

Further Details

Fundamentals

Most browsers cap the display of image files based on file size. We now will downsize an image file that is too large to display and provide an appropriate warning.

VitroVivo

The Sequence File Generator App now handles insertion of replicates of standard curves or quality control samples. Each replicate sample is uniquely identified by appending the replicate number at the end of the sample name.

The SPR Zeroing App now has increased performance along with a simplified interface consistent with other SPR Apps.

Biological Sequences

Users may now optionally choose to represent any DNA sequence as a single strand. To toggle the sequence the user must enter the Full Size (Experiments) or Dynamic Mode (Materials. The toggle choice will be preserved in the users local browser storage.

Any sequence that includes information designating the uploaded sequence as single stranded will now be displayed as such by default. Previously these sequences were automatically converted to double stranded sequences.

Chemistry

When using the Browse Materials option from the Chemical Drawing in an Experiment, Parallel Experiment, or a Sub-experiment, the option selected (Materials, Containers, or Samples) will remain for future selections when using the same browser until the cache has been cleared.

The HELM Monomer Curation (HMC) App is available in Beta with this release. The app will allow users to bulk upload custom monomers into configured libraries. These custom libraries will then be available for use with the HELM Editor within Signals Notebook. In this release, the HMC App also allows users to browse available libraries, view monomers in detail, and access Reports.

New administrator configuration options are available to provide users with access to the HMC app. System Administrators will have access by default. The app can be accessed via the Signals Home Page and via the App switcher within the Signals Research Suite.

Admin Defined Tables

Adding instructional text to headers and column headers

The administrator can now add instructional text to the Headers and Column Headers for Admin Defined Tables. This text is displayed to the end user via a tooltip.

We have also extended our calculations to include Log, Natural Log and Inverse Natural Log (Exp).

Worksheets

The ability to embed Admin Defined Tables within Worksheets is now available to all systems.

Embedded tables included in the printed content when exporting to PDF

The embedded tables are now also included in the printed content when exporting to PDF. If the option to include attachments is selected, a csv file of the contents is also included in the PDF attachments.

Plates

Non limiting reagents can now be added as an amount ratio relative to the limiting reagent. The amount ratio can be defined as w/w, i.e. grams per gram of limiting reagent, v/v, i.e. milliliters per milliliter of limiting reagent, w/v, i.e grams per milliliter of limiting reagent, or v/w, i.e. milliliters per gram of reagent. The additional column is hidden by default but can be shown if desired.

Inventory

Admins can now move contents of a location to a new location.

The chemist can also capture a snapshot of their planned amounts. The “Record Planned Amounts” control will capture a snapshot of the current Sample Mass, Volume, Moles, Eq and Amount Ratio in equivalent read only planned amount fields. The Clear Planned Amounts will remove the values, or using Record Planned Amounts again will update the values.

If there are sublocations with the same name, users will need to indicate how to handle the duplicate naming. Deletion of the sublocation in the “move to” location will only occur if the location is empty.

The containers and sublocations (if existing) of the location will be moved. The container, sublocation and container barcodes will remain the same as prior to the move.

Users are notified once the move has been executed and can download a report from Inventory Bulk Results under the user profile that contains details about the move.

If the location has a large amount of contents, the results page will show jobs that are In Progress. If more than one job is requested at a time, the jobs will queue in the results page.

Note: Moving into a grid location is not currently supported (selection of the coordinates is not available). If a grid location is a sublocation of a to be moved location, the grid location and the containers will be moved. If a grid location is select to be moved to a non-grid location, the containers will be moved but will no longer have coordinates.

Materials

Registered Chemical Material types (e.g. Compounds) can be bulk updated with SMILES, InChI, or HELM formats.

The HELM format is now supported for bulk registration of Materials. Upload and structure representation is supported for Chemical Material Types. Conversion of HELM strings requires that the tenant administrator has activated the requisite HELM libraries that enable the uploaded HELM strings to be converted into an expected monomer representation.

Administration

Upper-level objects in the Configuration Transfer file now indicate when the lower level items are partially selected.

ChemDraw documents in system templates now give you the option to update table definitions

ChemDraw Documents in System Templates now provide an option to update to the latest stoichiometry table definitions, as defined by the System Administrator in Chemistry settings. The Update stoich definition will appear in any ChemDraw Document in any System Template.

The existing beta for HELM Monomer Libraries has been extended to enable administrative privileges to control the management of HELM Monomer Libraries. The Create & Manage Libraries privilege allows users to configure new HELM Monomer Libraries, change the library sort order, activate or inactivate libraries, and delete custom libraries. The Access Monomer Curation App privilege allows users to navigate to the HMC App and view libraries to which they have access via the security policy. The Add New Monomers privilege allows users with the correct security policy to bulk import monomers via the HMC app.

Integrations & API's

The POST /entities endpoint has been enhanced to allow for Tasks to be created.

Tasks created with the POST /entities endpoint require an ancestor. This can be its direct parent (a TaskContainer) or its grandparent. A grandparent can be one of the following: an Experiment, Parallel Experiment, Request, Custom Admin Defined Object. In the case of a grandparent if a TaskContainer does not already exist as a child of the object it will be created, and the new Task will be added to it.

A task template is also required.

Optionally the endpoint allows for the Tasks fields, such as Reference ID(s), to be set via the attributes.

The documentation for the enhanced endpoint has been updated to include details on Task creation and example bodies for creating a task with and without a Reference ID field being set.

Additionally, we have added new endpoints to retrieve, add, update, or delete an Attachment in the Attachment type field to a Container or Location via the API.

The new Inventory endpoints are:

– GET /inventory/locations/locationId/fields/fieldId/attachment, download the attachment

– PUT /inventory/locations/locationId/fields/fieldId/attachment, add or replace the attachment

– DELETE /inventory/locations/locationId/fields/fieldId/attachment, delete the attachment

– GET /inventory/containers/containerId/fields/fieldId/attachment, download the attachment

– PUT /inventory/containers/containerId/fields/fieldId/attachment, add or replace the attachment

– DELETE /inventory/containers/containerId/fields/fieldId/attachment, delete the attachment

23.6 July 2023 (Update to E3 in November 2023)

What's New

This version 23.6 release of Signals brings enhancements to Search, Inventory, Signals Inventa and VitroVivo workflows. We have added new administrative settings to allow for the system to remember recently used values on experiment creation, and to change the interpretation of certain mol files on import. We have also The Worksheets, Sequence based search and Internal Data Source capabilities previously in beta are now available to all systems. We have added new beta capabilities around improved bulk import to chemically aware material libraries and the ability to embed admin defined tables into Worksheets. Finally, we have also fixed a number of small bugs.

The following improvements are available for users of Signals Notebook Individual Edition, Signals Notebook Standard, Signals Notebook Private Cloud, Signals Research Suite Standard and Signals Research Suite Private Cloud. Certain features may only be available with appropriate licensing and/or with enablement by an administrator.

VitroVivo
– Calculations Explorer enhanced user experience
– Secure connectivity with Signals Image Artist
– Experiment-agnostic Spotfire DXP files
– Improved SPR file loading and SPR Apps performance
– Automated addition of in vivo event ADTs to experiment through internal API
– Improved user interface in Sequence File Generator App
– Ability to export the Sequence File in Sequence File Generator App

Inventa
– Compound Material Sync and ChemCharts compatibility
– Out of the box maps for Material Sync and VitroVivo workflows
– Inventa Rebranding to Revvity Signals

Worksheets
– All previously released capabilities available to all systems
– Transfer configuration of Worksheet Templates
– Display of limit of number of properties in a Worksheet Template
– Embed Admin Defined Tables into Worksheet Templates (beta)

Inventory
– Bulk update Inventory Security
– Container search, link, and decrement from Materials Tables (beta)

Materials
– Bulk import/export chemical materials as SMILES or InChI (beta)

Search
– Define time when using date/time filters in Advanced Search
– Search for multiple values (OR) in a property in Advanced Search
– Biological Sequence search available to all systems

Administration
– Define time when using date/time filters in Advanced Search
– Search for multiple values (OR) in a property in Advanced Search
– Biological Sequence search available to all systems

Integrations & APIs
– External Actions on Search Results
– Update to GET/Worksheet to include details on embedded tables
– POST Plates
– API Endpoints for content layout

We also fixed several small bugs in this release. Details of the enhancements are described below.

The following OnDemand video for Signals Notebook Administrators are now available:

Creating and Utilizing Worksheet Templates

Administrator notes for current release.

Administrators should note that we will be updating the Concentration field in the Materials Library and Variable Measures using the measure called “Count” to be a COUNT measure instead of an INTEGER. The entered values will not be affected. Any use of the external APIs using this field may need to be updated appropriately.

Administrators should note that to keep up with industry standard best practices and ensure the security of our customer data, we have added support for TLS version 1.3. We will remove support for TLS 1.2 in a future update. Although most browsers will automatically select the version of TLS to use, older versions of browsers may be unable to use TLS 1.3 and will need to be updated. Additionally certain integrations may specify the version of TLS being used, in which case these integrations should be updated to reflect the change. This update applies to all Signals Notebook and Signals Research Suite environments including those on our Deferred Release.

Administrators are recommended to subscribe to the channels within our support news site which contains more information about releases and other pertinent product information.

This content is anticipated for release on our Production E3 environments, and for Private Cloud customers on our deferred release schedule, in November 2023.

Further Details

The following improvements are available for users of Signals Notebook Individual Edition, Signals Notebook Standard, Signals Notebook Private Cloud, Signals Research Suite Standard and Signals Research Suite Private Cloud. Certain features may only be available with appropriate licensing and/or with enablement by an administrator.

VitroVivo

The User Experience of the Calculations Explorer is evolving to become simpler and more user friendly. The panel to access the Calculations Explorer now shows clean sections to create new templates, apply existing templates on a new dataset or manage the available templates.

The main panel of the Calculations Explorer is now clearer, with actions visually organized in agreement with their importance and components that only appear when they are needed.

Performance and security have also been enhanced in the context of the SPR Apps and the connectivity with Signals Image Artist.

System Administrators are no longer required to create matching ADT templates for In Vivo events such as dosing event or sampling events in SN Config. Now, required event ADTs will be automatically created in an experiment page using internal APIs based on the template selected by the user in the Study Designer app. This new update also eliminates the need for users to manually add these tables to their experiment page before launching the Study Designer app.

The Sequence File Generator App has an improved user interface now to provide a cohesive and seamless user experience. The new design replaces the tab navigator with a dropdown selector that simplifies the process of choosing the type of sequence to insert.

Also, users can now export the generated sequence file in either CSV (Comma-Separated Values) or TSV (Tab-Separated Values) format.

Inventa

Synchronized compound structures from Signals Material Sync are now compatible with advanced chemical visualizations in Inventa. Behind the scenes, structures are published to Inventa in both CDX and Molfile formats, with the latter ingestible by Inventa’s ChemCharts.

Inventa now comes pre-loaded with a set of parent and detail maps compatible with the output of two VitroVivo workflows: 4P Dose Response-IC50 Assay Workflow and ELISA Assay with Standard Curve Workflow. The maps are available directly from the Publish Measurements app.

A pre-loaded map for the Compound Library map is now also available for administrators setting up the Signals Material Sync.

We have begun the rebranding process, representing our new company name: Revvity Signals. You’ll begin to see ‘Revvity’ referenced throughout Inventa. Logos and color schemes remain unchanged. Rebranding efforts from Inventa and VitroVivo will continue in the next release.

Worksheets

All of the Worksheet capabilities already released are now available to all systems and no longer need to be requested. The configuration of Worksheet templates can now be transferred between tenants.

We have also added a count for the number of properties in a Worksheet template, the maximum count for any single Worksheet template is 500 properties.

Administrators can now embed previously defined Admin Defined Table templates as properties in Worksheet Templates.

The Table is then available in the Experiment to Worksheet editors along with all other fields in the Worksheet.

Searching for properties in the embedded table will return the Worksheet.

Inventory

Update Security is now available on multiple Containers from the Barcode Search Bulk Actions page.

Users with access to the attributes through their group associations or security policy will see options available to them in the drop-down list to choose from:

Administrators can now activate Inventory from the Material Types configuration in the Materials Library. Navigate to Materials, choose a Material Library and view the Material Table to see the toggle.

Once activated, columns for Inventory Decrement, Barcode and Container ID will appear.

Users can then scan or type in the barcode to a container into the ID column of the Materials Table. Invalid barcodes will provide a warning to the end user.

Users can choose to use the Search function instead of the barcode scan/type. By choosing the magnifying glass and changing the drop-down menu to Containers, users will be able to find containers associated with the type of Materials Table.

The user can select one or multiple containers or materials to add to the Material Table:

Once a value is typed into the Inventory Decrement column, users will get a warning when trying to delete the row:

If a user tries to revert the Material Table through the history and the Inventory Decrement value currently entered does not match the same value in the history that has been selected to revert to, the revert will not be allowed:

Search

We have enhanced search filters in Advanced Search to allow definition of time for properties of type Date/Time.

Users can now search for a list of values separated by OR in a single filter. They can simply select “list” and manually enter a list of space separated values in the filter field.

Lists of values can also be copy/pasted into the list field from a text document or spreadsheet.

The Biological Sequence Search, previously under beta release, is now available to all systems. Users can search for biological sequence files across Signals Notebook using exact match, substring match, blastn, or blastp.

Administration

The Internal Data Sources capability recently released in beta is now available to all systems and available without request.

The administrator can now define how ambiguous mol files are interpreted. Certain mol files can contain contradictions in their definition whereby the top level chiral flag may define the molecule as achiral, while the bonds block defines discrete chirality for certain bonds. Although the mol standard defines that the top level flag should take precedence in such cases, and the compound should be interpreted as achiral, many chemically aware software applications treat such files as the opposite and respect the chirality defined within the bond block. The administrator can now define which was to treat such files via a setting in Chemistry Settings.

When selected the bond chirality will be respected regardless of the setting of the top level chiral flag. In the example below, Reactant I was imported with the setting as enabled, Reactant II as not enabled.

A combination of an Admin and end user setting will allow end users enable an autofill recently used values option for Experiment type object creation pages.

Admins need to enable access to the setting the User Settings in Configuration.

When this setting is enabled, users can enable the setting as well under their user settings.

Once enabled by both user and admin, the most recently used value for dropdown lists in fields in the experiment (or ADO, Parallel Experiment, request) creation page will be auto-populated. Users can still alter the values for these fields by clearing the value and selecting another if needed.

In the event that a field has a default value that differs from the most recently used value, the default will still be auto-populated.

Integrations & API's

Admins can now generate an external action on a selection of Search results by choosing the action to occur on one of the Smart Folders such as the Experiments Smart folder, or on Advanced Search results. Actions on “Folders” or search results must use the HTTP POST submit method as the search results are included in the body of the call made.

Admins are able to select to which search Folders the action applies, Advanced search and/or the entity smartfolders.

Once the action is set up and enabled, the user can run the action on their search results by entering selection mode in search selecting the actions icon.

Once in selection mode, users can then select a maximum of 100 items to send to their external action by selecting the “Action on Selected” button and selecting their external action from the dropdown. If fewer than 100 items are returned in the search, the user can select “Action on All” and their external action to send all returned entity IDs to the external action.

The existing endpoint GET/worksheet/{eid} will now return details of any embedded tables requested under our beta trial described below. The table details can be retrieved, or edited, via the existing endpoints for Admin Defined Tables.

New endpoints have been created for managing Plate Containers and their Plates

The new endpoints for Plate/Plate Container management are:

– POST /plates, create a new plate container.
– GET /plates/plateContainerId, get plate container by id
– POST /plate/plateContainerId/plates, add a new plate to a container
– DELETE /plates/plateContainerId/plates/id, remove a plate by id

We have also added new endpoints that allow programmatic creation, manipulation, and deletion of Layouts of Pages for Entities that contain UI page layouts such as Experiments, Samples, and Requests. You can now get the details of your UI page layout, add/remove/rename/reorder Pages, Reorder contents of a page, and move contents from one page in a Parent to another.

The new endpoints are:

– GET /entities/{eid}/layout/pages, Get all the UI layout pages of an Entity
– POST /entities/{eid}/layout/pages, Add a new page to the UI layout of an Entity
– GET /entities/{eid}/layout/pages/{pageId}, Get a specified UI layout page in an Entity
– PATCH /entities/{eid}/layout/pages/{pageId}, Change the name of a layout page or move the page to a new location
– DELETE /entities/{eid}/layout/pages/{pageId}, Remove the page from UI layout if it is empty
– GET /entities/{eid}/layout/pages/location, Get the location of a child entity in the parent UI layout.
– PUT /entities/{eid}/layout/pages/location, Move the child entity to a new location in the parent entity UI layout.

Chemistry

Admin Defined Tables

The administrator can now add instructional text to the Headers and Column Headers for Admin Defined Tables. This text is displayed to the end user via a tooltip.

We have also extended our calculations to include Log, Natural Log and Inverse Natural Log (Exp).

Materials

SMILES and InChI are now supported for bulk upload of compounds via CSV. There is a new example .zip file to provide a guide for uploading CSV with the new structure data.

Users may also export chemically defined Materials as SMILES or InChI format. Previously users could export these libraries without any chemical structure data. Please note that the export converts the structure data from the default standard in Signals Notebook.

23.5 June 2023 (Update to E3 in November 2023)

What's New

This version 23.5 release of Signals brings improvements to Signals Research Suite through Signals VitroVivo and Inventa, Inventory and Materials. We have continued to work on our ongoing beta capabilities for Worksheets and Internal Data Sources and added a new beta capability around HELM monomers. Finally, we have also fixed a number of small bugs.

VitroVivo
– Revised and improved data model for in vivo applications
– New Sequence File Generator App for creating sample run lists for LC/MS assays

Inventa
– External Data Sources
– SAR Layout Permissions
– Append structures to measurement tables
– Clone measurement types

Chemistry
– Copy structure(s) as formats other than CDX, CDXML
– HELM Monomer editor (beta)

Worksheets
– Improved administration view for editing and previewing Worksheet templates
– Integer fields will show a warning if number not in specified range
– Integer fields will not allow entry if number not in specified range
– Date/Time fields will show a warning if number matching a certain time relative to the time of entry
– Date/Time fields will not allow entry if number matching a certain time relative to the time of entry

Inventory
– Variable Measure Property
– Attachments for Containers and Locations

Materials
– Hide empty fields
– Option to expand the canvas of chemical materials

Administration
– Select next level content in Configuration Transfer of Admin Defined Objects
– Updates to Inventory Admin Role, Inventory Admin System Group

Integrations & APIs
– Multiple API Keys per tenant
– Internal Data Sources (beta)
– Limiting moles/solvent ratio
– Enter, update or clear a value for a Timestamp field in Worksheets
– Reopen Experiments, ADOs, Parallel Experiments
– API endpoint to Refresh External Lists

We also fixed several small bugs in this release. Details of the enhancements are described below.

Administrators should note that we have changed the way that the Inventory Administrators have access to Inventory functionality in System Configuration. We have added an Inventory Admin System Group, to which all users with the Inventory Admin Role are automatically assigned. The Inventory Admin role will now also be permanently assigned relevant privileges for the management of Inventory including all Container and Location related privileges. If Administrators would prefer that current users with the Inventory Admin role do not have all of these privileges, they should create a new Role for these users and assign the desired privileges.

Administrators are recommended to subscribe to the channels within our support news site which contains more information about releases and other pertinent product information.

This content is anticipated for release on our Production E3 environments, and for Private Cloud customers on our deferred release schedule, in November 2023.

Fundamentals

Full content names exceeding the width of the side contents pane can now be reviewed with a simple hover over tooltip.

VitroVivo

The data model for in vivo applications has been revised and improved to support design and execution of advanced animal studies involving multiple treatment cohorts. This new data model will now support creation of study cohorts (e.g., Male or Female cohorts, Wild Type or Transgenic cohorts) and associated treatment groups.

Users can now have access to the new Sequence File Generator App in the In Vivo Apps section. This App will help users to create a run list of samples for LC/MS Instruments from existing plate designs.

Inventa

Administrators can now connect External Data Sources, allowing them to leverage SQL queries to directly import data for mapping and indexing.

Users can now specify the privileges on shared SAR Layouts: Read, Write, or Full Control. Those with Read privileges and view and use a SAR Layout, but cannot modify its settings. Write privileges grant the ability to edit, and Full Controls adds the ability to share and delete a layout.

Users now have the option to append structures to measurement tables retrieved via Global Search. A column of structures can be applied to both Parent and Detail level measurement types, and the settings saved with the query.

Administrators can now clone measurement types. Cloned measurement types will inherit all the attributes and secondary mappings as the original measurement type.

Chemistry

Users have additional formats available for the Copy as function for chemically defined items. Selected structures may now be copied as HELM, HELM (Natural Monomers), SMILES, MOL V3000, MOL V2000, InChI, InChI Key, or SLN.

Inventory

The Variable Measure Property is a new field type that is available to Administrators in Inventory and Materials (batch/lots as well as compound/assets). It allows Administrators to choose which unit families the users are able to select from:

The list shows the family units as well as the conversions to the end users when entering values into properties using these property types:

Containers and Locations have a new field type of Attached file that can be used to upload documents. Admins can create the properties in the Inventory Containers or Locations Properties:

Administrators will need to add the property to the Container or Location type:

Existing Container/Locations will have the new field available upon edit. Users will see a note at the top of the screen identifying the new property:

When users create new Containers/Locations, the property is available to have a document uploaded:

Materials

In the Material Properties tab of a Container in Inventory, there is a filter option in the right top corner. This will hide any empty rows in the Material Properties tab when toggled on:

After:

In the Materials Library, in the Compound/Asset page there is the same filter option to hide empty rows:

After:

Users can now also enlarge the canvas for any chemical Material. The properties will still be on the page after expansion in both view and edit modes.

Administration

Configuration transfer of Admin Defined Objects now allows selection of the individual settings for Activation, Auto Numbering, Templates and others. By default the Auto Numbering setting is deselected and all other settings are selected.

The Inventory Admin role has been enhanced to facilitate access to the capabilities required. Users who are assigned the Inventory Admin role are automatically added to the new System Group called Inventory Administrators. They will also have some relevant privileges such as configure System, Inventory App and Manage System Templates automatically assigned. Only System Admins or Inventory Admins can activate or deactivate Inventory.

Integrations & API's

Admins can now generate Multiple API Keys per tenant to allow different API users to perform specific integrations. The maximum currently allowed per tenant is 10 API keys.

We have extended the GET/stoichiometry/{eid} endpoint to return the Limiting Moles/Solvent Ratio from ChemDraw Documents.

The PATCH/worksheet/{eid} endpoint has been enhanced to allow patch of a Timestamp property into a Worksheet. The request allows the developer to request that the value be “now” upon which it takes the current server time, or “clear” whereby the field value is removed.

We have added a new endpoint to allow a developer to reopen an Experiment, parallel Experiment or Admin Defined Object. The new endpoint POST/entities/{eid}/reviews/reopen will allow an experiment or similar object to be Reopened from Closed, Voided or In Review states.

We have added and enhanced endpoints to allow programmatic refresh of an External List. The endpoint POST/attributes/{eid}/refresh is an asynchronous endpoint which will queue the refresh of an External List. The status of the refresh is available via the endpoint GET/attributes/{eid}.

(Beta) Chemistry

Signals Notebook now includes native support for Hierarchical Editing Language for Macromolecules (HELM). This open format lets users represent complex and larger biopolymer modalities in a simpler format while maintaining all atom representation. To utilize the new feature, a Signals Notebook System Admin must activate any of three out-of-the-box HELM Monomer libraries. The configuration of these libraries is in a new section of Signals Configuration.

The libraries included in this release are the Natural Monomers, the Pistoia Alliance Monomers, and the Signals Monomers. System admins may choose to activate any of these libraries and change the sort order of the libraries. In this release, custom monomer libraries cannot be created, and no monomers may be added to any of the system HELM Monomer libraries.

New permissions are available, though only the management of Libraries is relevant for this release.

Access to the Monomer Libraries is dependent on Security Policy and Group Association Settings.

Once at least one HELM Monomer Library is activated, users with access will be able to access the HELM editor in any ChemDraw Canvas. This tool will enable users to add biopolymer building blocks one by one as well as enter a text string in several formats to quickly add a HELM structure to the canvas. Users may also quickly replace a monomer in an existing biopolymer. Users can toggle through different libraries and different monomer types to make their preferred selection. In this release, the Favorites tab will only store selections within the user’s local browser storage.

(Beta) Worksheets

We have improved the editing experience for Worksheet Templates. The button to add new fields is now more prominent and the administrator can now easily navigate between the Editor mode and Preview modes by accessing the two tabs. This allows the admin to define new fields, stay in the “Try It Out” mode to better iterate on their design.

Integer and date/time fields can now be set to enforce conditional entry. Integer fields can be set to only allow values above or below a given value, or values within or outside of a given range. The fields can also be set to allow values out of range but display the fields with a warning. Date/time fields can also be set with a condition, to prevent values, or to allow values out of range while providing a warning. Date/time value conditions are set relative to the time/date of data entry by the end user.

(Beta) Integrations & API's

Fields from internal entities can now be mapped into an Internal Data Source for use in ADTs similar to how fields for external sources can be mapped. This functionality has been expanded from just Materials and Samples to include: Experiments, ADOs, Tasks, Requests, Parallel Experiments, Notebooks, and Inventory Containers, and Locations.

A new “Internal Data Source” can now be created with admin defined fields. The admin can select from a list of available data types. The list of properties available for mapping is automatically filtered based on the selected data type.

Once the Data Source is defined, it can be used in ADT templates (including templates with formulations) similarly to how External Data Sources can currently be utilized.

When creating a table template the “External Data Source” option will now be a “Data Source” option and include Internal Data Sources. Key field identified with Key icon and automatically added to the template. Additional mapped columns can be manually added.

This differs from existing External Data Source behavior as currently all mapped External Data Source Columns are added automatically. The IDS requires that you manually add the columns as not all of them will consistently be needed. Mapping behavior is consistent with existing External Data Source functionality.

For the end user, the behavior of the Internal Data Source reference is very similar to the existing External Data Source behavior. Selecting the field brings up a pre-filtered search modal similar to what is available in QuickAdd. Mapped columns automatically populate in a manner consistent with what is available for External Data Sources

23.4 May 2023 (Update to E3 in November 2023)

What's New

This version 23.4 release of Signals brings improvements to Signals VitroVivo, Signals Inventa, integrated admin defined tables, Inventory, and some new administrative controls. We have released formerly beta capabilities around Material Tables, Sample Statuses and Inventory Decrements to all systems and these capabilities no longer need to be requested to be available. We have continued to work on our ongoing beta on Worksheets and added a new beta capabilities around Internal Data Sources and BLAST searching. Finally, we have also fixed a number of small bugs.

VitroVivo Apps
– New transformations captured in the Calculations Explorer (filtered rows and excluded columns)
– SPR Data import now supports files larger than 500MB and multiple files

Inventa
– Additional locking parameters for Publish Measurement App workflows
– Share options for SAR Layouts

Admin Defined Tables
– Improved handling of timeouts when calling multiple rows in a connected External Data Source

Materials Tables
– Bulk registration (available to all systems)
– Bulk edit (available to all systems)
– Upload from csv file (available to all systems)

Samples
– Statuses for Samples (available to all systems)

Worksheets (beta)
– Timestamp Field type allows end user to enter “Now”
– Fields can be required to have a value before signing
– Number and Number with Unit fields will show a warning if number not in specified range
– Number and Number with Unit fields will not allow entry if number not in specified range

Inventory
– Decrement Inventory containers from stoichiometry table (available to all systems)
– Revert experiments using Inventory Decrements in stoichiometry tables (available to all systems)
– Warn users when deleting an element or an experiment with linked containers and deprecated amounts (available to all systems)
– Additions to Total Amount in containers
– Switch containers in stoichiometry table (available to all systems)
– Updates to Switch containers in stoichiometry table

Materials
– Freeze column headers on Batch page

Search
– Biological Sequence search (beta)

Administration
– Product license assignment at user level
– Enable users to more readily find other users with differing email domains
– Limit end user sharing to only allow increasing access to user who already have View
– Change default to not transfer Starting Number for object Autonumbering when transferring configuration
– Prevent users from creating, editing or deleting comments

Integrations & APIs
– Internal Data Sources (beta)
– External Notifications on Export to ZIP/PDF
– PATCH Plates
– Bulk change Status of Samples

We also fixed several small bugs in this release. Details of the enhancements are described below:

The following OnDemand videos for Signals Notebook Administrators are now available:

Create mandatory content within templates Rel.May 2023
Inventory - Customizing Container Label Templates Rel.May 2023

Administrators should note that we are changing the way that the Inventory Administrators have access to Inventory functionality in System Configuration. We will be adding an Inventory Admin System Group, to which all users with the Inventory Admin Role will be automatically assigned. The Inventory Admin role will also be permanently assigned relevant privileges for the management of Inventory including all Container and Location related privileges. If Administrators would prefer that current users with the Inventory Admin role do not have all of these privileges, they should create a new Role for these users and assign the desired privileges. This change will be available in a future release.

Administrators and end users should note that we have updated the URLs used to access Signals. If you use a bookmark that does not have the “/elements” suffix, such as http://your_name.signalsnotebook.revvity.cloud or https://your_name.signalsnotebook.revvity.eu, then this URL will now go to a homepage that allows access to multiple Signals products. To go directly to your Signals Notebook please update your bookmark to append “/elements” onto the end of your URL, such as https://your_name.signalsnotebook.revvity.eu/elements.

Administrators and users should note that we will now purge old notifications, both end user notifications available under the bell icon, and External Notifications enabled via the administration console SNConfig. Notifications will now only be stored for 6 months. This change is implemented in this release.

Administrators are recommended to subscribe to the channels within our support news site which contains more information about releases and other pertinent product information.

This content is anticipated for release on our Production E3 environments, and for Private Cloud customers on our deferred release schedule, in November 2023.

Fundamentals

All users now have access to the redesigned Help Center. The content has been expanded to support Signals Research Suite.

VitroVivo

Two additional Spotfire transformations are now captured in the Calculations Explorer templates: Filtered Rows and Excluded Columns. To include transformations the user must enable the ‘Include transformations’ toggle accessible when selecting the table in the Create Template area.

SPR Data Import now supports files multiple files for Biacore (.blr files and Insight exported .json files) and Carterra instruments. Data files larger than 500MB are also now supported for all instrument types.

Inventa

Users can now lock the additional parameters in the Publish Measurements app when added to a Workflow. Notably, the individual mapping assignments and publish data method can be locked providing Workflow creators with more control over the publication process.

Users can choose to share a SAR table layout with one or more Groups or keep the layout private. Private layouts cannot be viewed or modified by other users.

Admin Defined Tables

We have updated the method that we use to load rows into an admin defined table, when the rows are sourced from an external database via a lookup ID. The lookups are now sent in batches, which alleviates timeout issues with larger sets of ID lookups.

Materials Tables

Materials tables enabled for registration will now be capable of bulk registration, bulk editing, and CSV upload. These capabilities, previously available under our beta released capabilities, are now available to all systems.

Samples

Sample Statuses, the ability to transition samples from one status to another, and associated privileges, in now available to all systems.

Inventory

The use of decrements from linked containers in the stoichiometry table is now available to all systems. This includes all associated capabilities including the ability to decrement Inventory containers from the stoichiometry table, to prevent reversion of experiments with decremented amounts in stoichiometry tables and to warn users when deleting an element or an experiment with linked containers and deprecated amounts.

The Batch and Containers pages now show a total number of containers available followed by the number of disposed containers, reported under the Total Container Amount:

A hover over window appears for a given compound that contains the Total Container Amount:

The ability to switch containers is now available to all systems. If no value is typed into the Inventory Decrement column, users will not get a warning. When users switch containers the name of the Material from the stoichiometry table will be at the top of the window. If the name of the Material name is blank, users will see the Material ID instead.

The column header will freeze to allow users to scroll longer lists of containers:

Materials

When users scroll vertically on the batch page, the headers will now remain visible:

Administration

The users page now supports product license assignment at the user level. License assignments can be set on the main user page, on the create and edit user pages, as well as with the bulk update. This revised Users page is only available on tenants with appropriate licensing.

We have added a new privilege “Broad User Search” to enable users to more readily find other users with differing email domains by first and last name instead of requiring the full email address.

This functionality will be available for user searching throughout Signals for example in Sharing and addition of reviewers.

Administrators can now also allow a more limited sharing option for end users via a “Read Dependent Share” privilege. Users with this “Read Dependent Share” privilege will be only be able to share content with other users who already have View access via the security policy.

If a user has been granted access via sharing and then loses View access to the entity via security policy, the sharing user only has the option to remove access via sharing and cannot grant further access or alter the level of access via sharing.

The Configuration transfer of Experiments, Notebooks, Parallel Experiments, Requests and Admin Defined Objects will now not transfer the Starting Number for the object Autonumbering by default. For Experiments, Notebooks, Requests, and Parallel Experiments, the setting can be enabled by the administrator if desired on import.

We have also added a new privilege to allow administrators to control if end user can create, edit and delete Comments. If a user does not have the “Add/Edit/Delete Comments” privilege they can still see existing comments but cannot write new comments, or edit or delete existing ones.

Integrations & API's

External Notifications can now be triggered on the export of entities to PDFs and/or ZIP files.

We have added a series of endpoints to our External APIs for the manipulation of Plates. The GET/plates/{plateContainerID}/plates, GET/plates/{plateContainerID}/plates/{id}, PATCH/plates/{plateContainerID}/plates/{id} and PUT/plates/{plateContainerID}/plates/{id} allow developers to get individual Plates, edit them or replace them. - See more at:

The endpoint PATCH/samplesTables/{samplesTableId}/rows has also been enhanced to allow for the bulk update of the Status of Samples.

(Beta) Worksheets

Administrators can now define a new property of type TimeStamp. When this property is added to a Worksheet the end user can enter the current date/time with a single click. Once entered the value can be removed, or updated with a new current timestamp.

Fields can also be defined as to require the end user to enter a value before a singing event can occur. If the end user attempts to sign a Worksheet where the fields are empty, the signing workflow will be prevented and the end user warned that there are fields to complete.

Admins can now also define that fields of type Number and Number With Unit only allow numbers within certain ranges to be entered. The admin can define that the value is accepted but shown as a warning if out of range, or that the value cannot be entered.

(Beta) Search

Fields from internal entities can now be mapped into a Data Source for use in ADTs similar to how fields for external sources can be mapped. This functionality is currently limited to Materials and Samples.

Once the Data Source is defined, it can be used in ADT templates (including templates with formulations) similarly to how External Data Sources can currently be utilized.

23.3 March 2023 (Update to E3 in July 2023)

What's New

In this version 23.3 release we are excited to announce the release of SaaS Signals Research Suite, a new offering with Signals Notebook, VitroVivo, and Inventa combined into a single product. Signals Research Suite provides comprehensive scientific data management and analytics supporting all R&D activities. Learn more. Signals Research Suite is built on the same platform as Signals Notebook, so any Signals Notebook users who are interested in seamlessly upgrading their implementation to the Suite are encouraged to contact their sales representative.

Further, this release brings changes to the Help, login home page and an app launcher to navigate between applications. We have brought a series of improvements to our Inventory capability and to the use of inventoried containers for Materials. We have continued to work on our ongoing beta on Worksheets and added a new beta capability around adding Statuses for Samples. Finally, we have also fixed a number of small bugs.

The following improvements are available for users of Signals Notebook Individual Edition, Signals Notebook Standard, Signals Notebook Private Cloud, Signals Research Suite Standard and Signals Research Suite Private Cloud.

Usability
– Release locks on Microsoft Office desktop files
– Email Notification for Shared Bookmarks/Queries
– Home App
– App Launcher

The following improvements are only available for users of Signals Notebook Standard, Signals Notebook Private Cloud, Signals Research Suite Standard and Signals Research Suite Private Cloud. Some capabilities may only be available with appropriate licensing.

Usability
– Display of External List derived Attributes in tables show additional detail in hover over

Signals Inventa & Signals VitroVivo
– Updated Help Center
– Signals Inventa dashboard & workflows
– TIBCO Spotfire for Signals install
– Administrative control of settings & user roles

Inventory
– Revert experiments using Inventory Decrements in stoichiometry tables (beta)
– Switch containers in stoichiometry table (beta)
– Total Amount in containers displayed in Materials, Display Total Amount of containers in Assets without Batches in Materials Library (available to all users)
– Searching for Total Amounts in containers

Materials
– Show/Hide Disposed filter on all Containers pages
– Disposed containers show with strikethrough on Containers page

Materials Table
– Registration from Materials Tables (available to all administrators)
– Create child materials from the Materials Table (available to all administrators)
– Creation of lots/batches with the Material Table (available to all administrators)

Samples
– Statuses for Samples (beta)

Administration
– Filtering for Worksheet locking events in Admin Audit trail
– Configuration transfer of Field Locking reasons

Integrations & APIs
– GET Field Locking reasons for use in editing locked Worksheet fields
– PATCH Worksheets with locked fields
– POST/PATCH containers includes home location
– Update Sample Status
– GET/POST/PATCH multi-value attributes lists sourced from External lists

Worksheets (beta)
– Indication that a locked field has been previously edited
– Return to Locked field to continue editing
– Print Worksheets

We also fixed several small bugs in this release. Details of the enhancements are described below:

The following OnDemand videos for Signals Notebook Administrators are now available:

Create mandatory content within templates Rel.May 2023
Inventory - Customizing Container Label Templates Rel.May 2023

Administrators should note that the capability to define reasons for changing locked fields used in Worksheets, which was described in the previous (23.2) update, was erroneously described as being in beta and only available on request. This capability is actually available to all administrators albeit has no utility without enablement of the Worksheets capability.

Administrators and users should also note that due to a change in our Chemical Drawing capability, Chemical Drawings will not load in versions of Safari older than 16.3. We strongly recommend that all users always use the most up to date version of their browser.

Administrators and end users should note that we will be updating the URLs used to access Signals Notebook in a future release. If you use a bookmark that does not have the “/elements” suffix, such as http://your_name.signalsnotebook.revvity.cloud or https://your_name.signalsnotebook.revvity.eu, then this URL will soon go to a homepage that allows access to multiple Signals products. To go directly to your Signals Notebook please update your bookmark to append “/elements” onto the end of your URL, such as https://your_name.signalsnotebook.revvity.eu/elements.

Administrators and users should note that we will soon be purging old notifications, both end user notifications available under the bell icon, and External Notifications enabled via the administration console SNConfig. Notifications will now only be stored for 6 months. This change will be implemented in a future release.

This content is anticipated for release on our Production E3 environments, and for Private Cloud customers on our deferred release schedule, in July 2023.

Useability

Users can now override any locks that exist on the editing of Microsoft Office documents when opening to edit in Microsoft Office Desktop. The user is informed if a lock exists and who owns the lock.

Overriding the lock will take control of editing the document, if the user with the previous lock is still working their changes will no longer be recorded. The lock override is recorded in the History as a discrete event.

Users are now able to receive an email notification when a search query is shared with them by turning on the email notification option for “When someone shares an item with me” in their notification settings.

The user will receive an email notification with a link to the search.

A New Home App allows easy access to subscriptions, tools, and other items to explore. The Home App will show applications available to you. Users can also navigate between Apps, and to the Home App by using the App Launcher accessible to the right of their username.

The following improvements are only available to users and administrators of Signals Notebook Standard, Signals Notebook Private Cloud, Signals Research Suite Standard and Signals Research Suite Private Cloud. Some capabilities may only be available with appropriate licensing.

Users will now be able to see additional detail for values from External List derived Attributes in tables with a hover over. This will apply to single-select and multiselect fields and will be available for ADTs, Materials, Samples, Tasks, Stoich tables, Worksheets, and Inventory Locations and Containers.

Signals Inventa and Signals VitroVivo

The Help Center has been redesigned with expanded content to support Signals Research Suite.

Users now have a dedicated dashboard for their Inventa Projects and Analyses.

The dashboard is backed by the new system object, Inventa Analysis. An example Inventa Analysis is provided out-of-the-box.

A dedicated smartfolder allows users to easily search through their entire Inventa Analysis collection.

Users can create a new Inventa Analysis by launching any of the Inventa applications from the dashboard or from the Add New button.

The Inventa Analysis contains an interactive preview of associated compounds that is linked to the SAR Analysis app inside of Signals Inventa.

Visualizations can be directly exported from Spotfire for Signals into the Inventa Analysis object. This allows users to capture visualizations at a snapshot in time. Visualizations inside the Inventa Analysis support annotations.

Within Spotfire for Signals, users can browse and open existing Inventa Analyses.

Users can now install TIBCO Spotfire for Signals from the Home App by clicking the install link under tools and following the instructions.

Administrators now have settings to manage Signals Research Suite. Inventa settings are found on the Signals Configuration Home Page and additional settings are found on the Revvity Signals Apps page within Spotfire for Signals.

Administrators can control which user groups have the privilege for managing VitroVivo and Inventa by setting privileges within Users Roles page in Signals Configuration.

Inventory

The ability to display Total Amounts of Materials in Containers, at the Material, Asset/Lot and Container levels, is now available to all users.

Users can now search for results via the Total Amounts of Materials in containers. The search filters are easily found by typing “ REPORT” into the Add filter option to see the 3 Amount Available search options, to search via Total Mass, Volume or Count. The filter can be further refined by defining ranges or other conditions similar to other numerical filters, or combined with other filters to narrow down results. The Total Amount filter is available from both Materials and Inventory searches.

The results returned can include both the Material in addition to the individual Batch/Lots if additional filters are not applied.

Materials

Disposed Containers can optionally hidden, or shown again, on all Containers pages.

Container pages are now displayed on all Material Libraries, both those with and without Batch/Lots. Disposed containers are shown with strikethrough on the Containers page.

Disposed containers are also shown with a strike through when the corresponding batch is expanded:

Materials Tables

The ability to enable registration functions from the Materials Table is now available to all administrators.

Enabling this option will expose capabilities for end users to Register Materials, Lots/Batches and Child Materials directly from Materials Tables as previously available under our beta released capabilities.

Administration

We have added an Action filter for the field locking events in the Admin Audit trail to facilitate administrators identifying changes to locked fields in Worksheets.

The Field Locking reasons can now also be transferred between tenants via Export/Import of the Configuration.

Integrations & API's

We have added a new endpoint GET/worksheet/settings/unlock/reasons to allow retrieval of the Field Locking reasons. The endpoint PATCH/worksheet/{eid} has also been updated to allow the reason ID to be used when editing a locked field.

We have also updated the POST/inventory/containers and PATCH/inventory/containers/{containerId} endpoints to allow definition of the Home Location of containers.

The Status of Samples can be updated programmatically via the new endpoint PUT/samples/{sampleId}/status.

The recent extension to allow multiple values in Attribute Lists derived from External List sources is now supported via our public APIs. Relevant endpoints, for Tables, Samples etc. now allow the retrieval and updating of such properties with multiple values.

Inventory

If a user tries to revert a change to a ChemDraw Document where the reversion would change the Decremented amount of a reagent, the reversion will now be disallowed and the user presented with an error. This is to prevent accidental inaccuracies in Inventory containers. Changes that do not require a change in the Decremented amount are still allowed.

Users who have attached container to the stoichiometry table via Quick Add/Search or type ahead now have a new “switch” icon in the Container ID field.

When clicked, the switch icon will present the user with a warning. If an amount is present in the Inventory Decrement cell, that amount is deducted from the currently selected container. To avoid this, users should update the Inventory Decrement cell to be 0.

Once Confirmed, users will have the option to change the container to a different container of the same material and batch/lot (if applicable). Containers that are deleted, disposed or final disposed will not be in the available list.

Once the new Container has been selected, the Reagent will be updated with the associated Barcode and Container ID.

Worksheets

Locked fields now indicate when they have been changed since entering the initial value. If the originally entered value has been updated, requiring the author to enter a reason for the change, the lock symbol is now displayed in blue to indicate that the field has changed at least once.

The Reason For Change dialog has been enhanced to allow the author to return to the field to continue making changes, without locking the field but without having to unlock the field again.

Worksheets are also now included when printing an Experiment to PDF.

Samples

Samples will now have a “Status”. The current Statuses are: Active which has the same behavior as what is currently available for Samples, and two new “Read Only” Statuses Closed and Canceled. Active samples can be Closed or Canceled. Closed or Canceled samples can be reopened if any edits must be made. Once a sample is canceled or closed, it cannot be edited, registered as a material, content cannot be added, and new containers cannot be added. Closed or Canceled samples can still be referenced in Tasks or referenced in the Quick-Add.

The Admin can limit which users are able to transition samples from one status to another through 2 new privileges: “Close/Cancel Samples” and “Reopen Samples”.

External Action triggers on Samples can now also be limited based on Sample Status. For all existing external actions on Samples, the trigger options default to showing the action in all sample statuses.

23.2 February 2023 (Update to E3 in July 2023)

What's New

This version 23.2 release of Signals Notebook brings additional capabilities for our ongoing beta capabilities for Worksheets, Materials Tables, Inventory Decrements and Amount Rollups. The prior beta capabilities around additional chemically aware libraries is now available to all administrators. We have also added the ability to use Externals Lists as multi-value attributes and for an administrator to manage any active tokens for integrated products using a bearer token exchange. Finally, we have also fixed a number of small bugs.

The following improvements are only available for users of Signals Notebook Standard and Signals Notebook Private Cloud

Inventory
– Warn users when deleting an element or an experiment with linked containers and deprecated amounts (beta)
– Display Total Amount of containers in Assets without Batches in Materials Library (beta)

Materials
– Additional Chemically Aware Libraries (available to all administrators)

Materials Table
– Bulk registration (beta)
– Bulk edit (beta)
– Upload from csv file (beta)

Administration
– View and Expire active Bearer Tokens
– Define multivalue attributes for External Lists

Integrations & APIs
– Replace ChemDraw Document
– Lookup total inventory amounts of materials

Worksheets (beta)
– List, multivalue list fields
– Text field supporting multiple lines of entry
– Lockable fields
– Definition of reasons for changing locked fields

We also fixed several small bugs in this release. Details of the enhancements are described below:

The following OnDemand videos for Signals Notebook Administrators are now available

Building Hierarchical Attributes

The following OnDemand videos for Signals Notebook End Users are now available

Using Hierarchical Attributes on System Objects and Admin Defined Tables

Administrators and users should also note that due to an upcoming change in our Chemical Drawing capability, Chemical Drawings will not load in versions of Safari older than 16.3. We strongly recommend that all users always use the most up to date version of their browser.

Administrators are recommended to subscribe to the channels within our support news site which contains more information about releases and other pertinent product information.

This content is anticipated for release on our Production E3 environments, and for Private Cloud customers on our deferred release schedule, in July 2023.

Further Details

The following improvements are only available to users and administrators of Signals Notebook Standard and Private Cloud and are unavailable as part of Signals Notebook Individual Edition.

Materials

The additional Chemically Aware Libraries previously released in beta are now available to all administrators.

Administration

Organizations who had enabled authentication for integrated applications via a Bearer Token Exchange can now view the users with active Bearer Tokens. A display of the active tokens per user per client (Application) is provided in the Administrative page, SNConfig. The admin can choose to expire all short term bearer tokens for a particular user, or for all short term tokens for all users across all applications across all clients. All long or short term tokens for a selected user and client can also be expired.

Administrators can also now allow multiselect for external list fields as can currently be done for other list fields. As with internal references, the additional information/properties for the external attribute appears in a preview when the user hovers over the information (“i”) icon.

Integrations & API's

We have added an endpoint PUT/chemicaldrawings/{eid}/reaction to allow developers to replace the underlying .cdxml file in a ChemDraw Document element. The existing .cdxml file can be downloaded via the GET/chemicaldrawings/{eid}/reaction endpoint, modified with any desired changes and replaced. This allows deletion, addition or editing of reagents and/or products. Edits to existing reagents and/or products will in most cases results in any end user entered data in the stoich tables being reapplied to the new structure.

The following capabilities are in beta and are only available to users and administrators of Signals Notebook Standard or Private Cloud upon request. Please contact your account representative or our support team if you would like access to the following features. They are unavailable as part of Signals Notebook Individual Edition.

Materials Tables

Materials Tables enabled for registration now support several actions in bulk. A table can be populated with multiple rows of data prior to registration of each item. Simply select all or some of the rows and utilize the bulk actions menu to register.

If any registration events fail in a bulk action, the user will be notified with row level errors. These events can be filtered for inspection by clicking on the ID column and selecting the type of error event. Mousing over the error icon gives the user an indication of the type of error that occurred. In this example, both rows are missing required fields.

Users may also edit existing items in bulk. Select the items to be edited and then use the Bulk Actions Menu to Edit those rows. Copy and paste actions can be used to quickly fill out a column of data. The user can close the edit mode from the Bulk Actions menu or by navigating away from the table will move the table out of the edit state.

Bulk actions include registration of new Materials as well as clearing or deleting rows without IDs. Rows with IDs can be deleted in bulk as well.

Users may also import a CSV to populate the Material table. CSVs with IDs will look up existing registered Materials while those without CSVs will populate the rows for supported fields. If a field fails to map to the table or if the field is not supported, the user will be notified and prompted to map or resolve the issue.

Materials tables can be downloaded as a CSV and we have also added an ability to copy selected rows to the clipboard with or without column headers or to copy just the Material IDs themselves.

Inventory

When users have linked containers and used the Inventory Decrement cell in the Chemical Drawing and then choose to delete the Chemical Drawing or the Experiment, a warning will show to let the user know that they may be making a change to the Inventory container(s) that they did not desire to do:

Users can now display Total Amount of containers in Assets without Batches in Materials Library.

Users can click the down arrow next to the totals to change the units if desired:

Worksheets

Administrators can now add properties of type List and Multivalue List to Worksheets. These lists are self contained within the Worksheet.

Administrators can also define that text fields can contain multiple rows of data. Multi row text data can be designated as a Rich Text field in the property dialog. Once added the end user can add more detailed textual descriptions into such fields.

Administrators can also define that certain fields are locked once content has been entered. In order to change the value, the end user must unlock the field, make a change, and provide reasons to be recorded for the change. The administrator can define a list of preconfigured reasons for the user to choose from.

23.1 January 2023 (Update to E3 in July 2023)

What's New

This version 23.1 release of Signals Notebook brings improvements to bookmarks and the ability to get data into admin defined tables. Admins can now change the understanding and display of aromatic compounds on import. We have continued to make improvements to our ongoing Worksheets beta and have added new beta features for Inventory around deprecating amounts and calculating total amounts in Containers. Some of the existing beta capabilities for Materials are also now on general release and available to all administrators. Finally, we have also fixed a number of small bugs.

The following improvements are only available for users of Signals Notebook Individual Edition, Signals Notebook Standard and Signals Notebook Private Cloud:

Usability
– Share bookmarks

The following improvements are only available for users of Signals Notebook Standard and Signals Notebook Private Cloud:

Chemistry
– Convert mol or SMILES to aromatic or alternating single & double bonds

Admin Defined Tables
– Match columns on importing csv files

Inventory
– Scan Location Barcodes
– Decrement Inventory containers from stoichiometry table (beta)
– Total Amount in containers displayed in Materials (beta)

Materials
– Creation of lots/batches with the Material Table (beta)
– Bulk export enhancements (available to all administrators)
– Export of materials by ID (available to all administrators)
– Bulk update of Materials (available to all administrators)

Integrations & APIs
– Convert export of mol files to aromatic or alternating single & double bond format
– GET/Materials includes sequence field values for Primers
– Endpoints for Worksheets

Worksheets (beta)
– Search of Worksheet properties
– Number with unit fields

We also fixed several small bugs in this release. Details of the enhancements are described below:

The following OnDemand videos for Signals Notebook End Users are now available:

Adding to the Reagents Materials Library

Administrators should note we have updated our adherence to the SCIM standards. The field “displayName” for the ResourceType Group is now be required. Additionally the field “value” in the “members” multivalue attribute is also required. Any calls to SCIM endpoints in our public APIs will now require these values and will fail if the values are absent. Administrators should change their API calls to incorporate these values if these values are not already included.

Administrators should note that as part of the new bulk export enhancements we added a new Export Materials privilege. This privilege is enabled for the Standard User and System Administrator roles only. System Administrators can optionally add or remove this privilege from any role except the System Administrators role. New tenants will not have this privilege enabled for the Standard User role by default. This privilege was enabled in 22.10 but erroneously left out of the What’s New for that version.

Administrators are recommended to subscribe to the channels within our support news site found at https://support.revvitysignals.com/hc/en-us which contains more information about releases and other pertinent product information.

This content is anticipated for release on our Production E3 environments, and for Private Cloud customers on our deferred release schedule, in July 2023.

Usability

Users are now able to share bookmarked search queries with other users and groups of users in their tenant. If a user has a query/bookmark they want to share with other users or groups, they can select the “Share Search Query” option now available on their bookmarks under the “Manage Bookmarks” page.

The user can then select the groups and users they wish to send the search query.

The receiving user gets a notification with a link to the search query in their In-App notifications.

These notifications are currently In-App only and are not sent via email. They can be activated or deactivated by selecting the “In-App” option for “When someone shares an item with me” under the notification settings.

The receiving user can add the shared query to their own bookmarks by selecting the link in the notification to bring up the shared search query and bookmarking the search themselves.

The following improvements are only available to users and administrators of Signals Notebook Standard and Private Cloud and are unavailable as part of Signals Notebook Individual Edition.

Chemistry

Administrators can now define that chemical structures containing delocalized rings, imported from mol or SMILES formats, can be converted from aromatic to alternating single and double bond representation, or visa-versa. This setting will be applied to structures pasted into a ChemDraw document that are in SMILES or mol format, or when structures are imported via SDFile. The setting will not apply to imported cdx or cdxml files.

For example if the setting is changed to “Alternating Double/Single Bonds”, pasted or imported SMILES strings or mol files that have an aromatic representation will be converted to display in alternating single and double bonds.

Admin Defined Tables

Upload csv to ADTs has been improved to accept data in hidden ADT columns and allow for mapping of columns if columns in the csv cannot be automatically mapped to columns in the ADT.

Csv columns are mapped automatically based on column name, order and data type. If the csv has columns that cannot be automatically, a modal pops up allowing the user to manually map the unmapped columns.

If the user does not map all of the columns and opts to import the csv without all columns mapped, only mapped columns will import.

Inventory

Users can now scan the barcode of a location in addition to the name type ahead. User can toggle between the barcode scan icon and the location icon to choose which to select the location.

The scan of the location barcode is in all the workflows where the location is required.

Materials

Enhanced bulk export capabilities are now available to all systems without request. This enables export of up to 5000 items from the Materials Smart folder. There is now the ability to export by Asset or Batch. Previously users were restricted to export of 50 items at the Asset level and the export included all batches.

There is also a new option to export a CSV of Compounds or Reagents (SNB). This export will include IDs and properties but will not include any chemistry data.

If the user leaves Signals Notebook during the export process they may retrieve downloads from the Bulk Export section of the Materials Bulk Results, accessed from the user menu. Note that a maximum of 50 results will be stored in the system and results will be stored for only 60 days before being purged from the system.

The Export by ID feature is now available to all systems without request. Users can submit a list of Material IDs for a given library to retrieve the download.

IDs must come from a single library but can include Asset or Batch ids for a given library. Compounds and Reagents (SNB) libraries can be downloaded as an SDF or CSV.

Bulk update of materials is now available to all systems without request. The update applies to a single type of Material per action and must include IDs that map to existing materials. The user selects fields to update after including an appropriately formatted CSV file. There is also an option to clear non-required fields during the update.

Bulk updates will include reports under the Materials Bulk Results. A file can be downloaded to understand why any updates were unsuccessful. Up to 50 results will be saved in the system and all results older than 60 days will be automatically purged.

Integrations & API's

We have enhanced our API endpoints that allow export of structures in various chemical formats to allow conversion to either aromatic or alternating single and double bonds. The aromaticRepresentation parameter applies to endpoints such as GET/stoichiometry/}eid}/{rowid}/structure. The parameter applies only when exporting to mol or SMILES formats.

The GET/materials/{eid}/properties endpoint has been enhanced with a parameter to include sequence information in the response. This enrichSequence parameter will allow the sequence property type data to be included in the response from libraries that utilize this property. This does not apply to when the sequence is determined from adding a sequence based file.

We have also added a GET/worksheet and PATCH/worksheet endpoint. These endpoints will be visible regardless if you have activated the Worksheets beta but will not be usable without having done so.

Inventory (Beta)

Users will now be able to decrement amounts from Signals Inventory containers from the stoichiometry table. Note: This functionality is not available in Parallel Experiments.

Administrators will notice that the Inventory Decrement column is available in the Chemistry Settings and hidden by default. The Clear value when element is copy-pasted is permanently defaulted to be checked. Administrators can make appropriate adjustments depending on if Signals Inventory is in use:

When users add Material or Sample containers to the Chemical Drawing, the Inventory Decrement cell will be available. When users type an amount into the Inventory Decrement cell, the amount will automatically be deducted from the container. Users will see a green checkmark in the bottom of the table. If the incorrect unit is used, the user will see a red x in the bottom of the table and will need to correct the action for the correct decrement to be completed.

Previous to typing an amount into the Inventory Decrement cell, the container had 0.5 g, the Current User was Unassigned and the Status was AVAILABLE:

After typing into the Inventory Decrements the container amount is updated, the Current User is changed to the signed in user and the Status changes to “IN USE”.

If the decrement typed is larger than what Inventory has recorded, the user will be able to complete the decrement, but the container will automatically have the Status set to EXHAUSTED:

If the user deletes the row or the drawing and has a value in the Inventory Decrement field, a warning will appear:

If the user closes the experiment but forgets to type a value into the Inventory Decrement, they will get a warning. Users can continue and close the experiment or cancel out and go back and update the amounts in the Inventory Decrements:

Users will also now see the Total Container Amount of a Material reported on the Material’s details page. The total amount is reported as a sum based on the unit type selected. For example, if the material has containers in both mass and volume, the amount total will add all the mass containers and report it in grams. The same is true of volume and the total will be reported in milliliters:

Count will be reported as a number with no units. The Total Amount per Lot or Batch is reported in the Container Amount column on the Batch/Lot page:

Containers that are in the Exhausted, Disposed or Final Disposed status will not be counted in the Amount Total. Containers in the Disposed or Final Disposed Status will no longer show by default in the expanded container view:

To view disposed containers or to hide empty columns use the filter icon in the top right corner of the table:

Materials (Beta)

With the beta feature enabled it is possible to use Materials tables configured for registration to also create batches/lots of an existing material. This is possible for all Materials with Asset/Batch configuration, including Compounds and Reagents (SNB). Admins must first enable a given Material Table for registration or batch creation:

To create a new batch of any given material, users must first add a valid item to an existing Materials table. The user will then see a new option to create a batch/lot from the menu item next to the item ID.

A modal will then open and allow the user to enter metadata and specify the number of batches to create.

Once completed, the batches will appear in the Materials Table with IDs. Note, Compounds and Reagents (SNB) cannot be edited from the materials table. To update values after creation the user will have to navigate to the individual batch in the Materials Smart Folder.

Worksheets (Beta)

We have enabled search on Worksheets. Worksheet elements can be retrieved via searching for Type=Worksheet. Additionally the properties filled in within worksheets can also be searched, each property is prefixed with “Worksheet”.

We have added a new property type for numbers with units. Administrators can now define united number fields in Worksheets, whereby they select the property type, select the measure type, such as mass, and can define a default unit, such as grams.

2024 2022 2021 2020