AutoChrom®
Method Development Software for the Chromatography Expert
Automate complex LC and GC method development with workflow-driven experiment planning, execution, modeling, and optimization. Accelerate robust, stability-indicating and other challenging chromatographic methods.
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Develop Chromatographic Methods in Less Time
AutoChrom streamlines method development from start to finish using QbD principles and a structured, workflow-based approach. Spend less time on manual processes and more time on science
Start Smart—Begin with reasonable starting conditions and columns. Guided software wizards and assistants help define and implement your strategy from the outset.
Automate and Optimize—Automatically run experiments for screening and optimization, then model your separation in 1D, 2D, or 3D
Capture and Learn—Document the reasons for your decisions and database your projects for future learning
Benefits
Tools for Method Development and Project Management
Take a strategic approach
- Start your project by predicting compound properties and building a development strategy.
- Work through the steps logically and move closer to optimization with every experiment.
Manage your project from start to documentation
- Document your decisions for data integrity.
- Store the workflow alongside the experimental data and solutions.
- Upload everything to a searchable database so your team can find it again.
Automate screening and optimization trials
- Walk away, and AutoChrom Online will run your experiments automatically according to your strategy.
Find optimal conditions by simulation
- Optimize your separation in 1D, 2D, or 3D with color-coded resolution and suitability maps.
Algorithmically track peaks between runs
- Track a compound across multiple chromatograms by UV or MS spectra, with help from AutoChrom’s algorithms.
Reduce unnecessary experiments
- Cut down on experiments and development time with simulation and computer-assisted modeling.
Industry Insights—Where Science Meets Strategy
Features of AutoChrom
AutoChrom FAQs
AutoChrom is a method development software that uses predictive modeling, simulation, and optimization tools to develop LC and GC methods more efficiently. Users can evaluate chromatographic conditions virtually and identify optimal methods with fewer laboratory runs.
The software supports both liquid chromatography (LC) and gas chromatography (GC) method development, and allows scientists to analyze, process, visualize, and report chromatographic data from multiple instruments and vendors. It automates tasks such as peak integration, quantitation, data review, and reporting to improve efficiency and consistency across analytical workflows.
AutoChrom replaces trial-and-error with data-driven chromatography method development. Using retention modeling and simulation, scientists predict separation performance across pH, temperature, gradient, and column variables, before running physical experiments. This reduces screening runs, accelerates LC and GC method development, lowers solvent consumption, and delivers more robust methods faster.
AutoChrom uses predefined rules and intelligent algorithms to automate the data processing workflow from data import and peak processing through to quantitation, calculations, and reporting. By minimizing manual intervention, laboratories can handle larger sample volumes, reduce analyst workload, improve consistency across projects, and free up time for higher-value data interpretation rather than routine data handling.
AutoChrom supports multi-vendor instrument environments, allowing laboratories to work with chromatography data generated by different instrument manufacturers within a unified workflow.
AutoChrom supports chromatographic data import and process chromatographic data from leading instrument manufacturers and data systems, seamlessly integrating into your existing workflows.
Yes. AutoChrom enables consistent, automated processing methods, calculations, and reporting across laboratories, teams, and geographic locations, eliminating variability introduced by manual interpretation. Built-in column comparison and selection tools further support method transfer between columns and instruments, ensuring reproducibility throughout method development and optimization.
No replacement needed. While traditional CDS platforms focus on instrument control and data acquisition, AutoChrom extends beyond this—automating data processing, workflow standardization, reporting, and knowledge management across multi-vendor environments. Most laboratories run AutoChrom alongside their existing CDS, enhancing analytical workflows without disrupting current instrumentation or data acquisition processes.
AutoChrom helps laboratories work across multiple instrument platforms and data sources rather than being tied to a single instrument vendor. This flexibility can support standardization across diverse laboratory environments.
Yes. AutoChrom is designed to help laboratories manage large volumes of chromatographic data by automating repetitive processing tasks and applying consistent rules across datasets.
AutoChrom supports QbD method development by automating chromatography modeling and optimization. It predicts retention times, evaluates method robustness, and systematically explores design space, enabling scientists to develop regulatory-compliant analytical methods faster with fewer experiments.
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