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Demos Trials

Seamlessly advance RNA design from concept to candidate

Signals Notebook and Signals One™, with integrated HELM -capable ChemDraw®, help research teams design, create, and analyze RNA constructs, putting stability, chemistry, potency, and efficacy data within a unified, searchable system.

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End-to-End RNA Therapeutics Discovery with SignalsOne: From HELM Based Design to Data-Driven Candidate Selection

  • How to design and capture RNA oligonucleotides using ChemDraw-powered HELM notation
  • How to register, manage, and search experimental data in Signals Notebook
  • How to streamline testing and analysis using integrated SignalsOne and Spotfire tools
  • How end-to-end integration supports faster, more informed RNA candidate selection
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    Design

    Design RNA candidates with precision and flexibility

    For all RNA applications and designs, HELM notation is the basis for a unified, modular design platform that can visualize your candidates with precise, complete molecular information. From ASOs to mRNA, siRNA to LNP-conjugated constructs, ChemDraw® with HELM, in Signals Notebook and Signals One™,   can help your team build and share RNA constructs without losing essential chemical details.

    • Visualize and register natural, unnatural, and chemically modified sequences using HELM notation
    • Document conjugations, base/backbone modifications, and structural features, such as GalNAc, PEG, and LNPs
    • Integrate your designs into the workstream with consistent formatting and notation, without losing any information in handoffs 

    Unify nuanced RNA designs and diverse scientific teams with a cross-disciplinary solution.

    Explore HELM-powered ChemDraw design of your RNA in Signals Notebook  

    make

    Track every step from RNA concept to construct

    Move from digital design to wet-lab synthesis with full traceability. Signals Notebook ensures every variant, formula, and modification is registered, recorded, and accessible.

    • Record each candidate’s synthesis, sequence, chemical modifications, and formulation properties with structured entity tracking
    • Automatically link assay data to parent constructs to enable lineage-based optimization as you test new variants and formulations
    • Prevent data loss and duplication by keeping variant histories connected and organized
    • Capture the evolution of your RNA portfolio in full detail.

    See how Signals Notebook supports RNA synthesis workflows 

    test

    Characterize with confidence by linking experimental data to RNA construct

    From cellular knockdown assays to in vivo stability studies, Signals One keeps everything structured and linked as you evaluate your candidates.

    Characterizing RNA candidates requires a myriad of experiments, including cellular and cell-free assays. Signals One helps save time and effort by organizing knockdown or translation efficacy, RNA stability, off-target effects, and any other structured data organized and linked to the tested construct.

    • Flexible and customizable workflows support your pipeline, from quantitative PCR to thermostability and everything in between
    • Automatically capture structured assay data to build a comprehensive profile for each candidate
    • Save time and avoid costly mistakes associated with manually compiling data from each experiment and candidate
    • Analyze more data with less effort with automated data clean-up and analysis
    • Build detailed profiles for each candidate and their variants with the Signals One unified system.


     Explore RNA characterization workflows in Signals One

    test

    Advance the right RNA candidates with clarity

    Signals One helps you weigh efficiency, safety, delivery, and more, using robust multiparameter optimization (MPO) tools.

    • Multiparameter optimization (MPO) integrates structure, assay data, and metadata across modalities, helping teams spot trends and opportunities
    • Use principal component analysis and other automated analyses to identify trends across your library
    • Visually compare and rank multiple candidates with the Signals One visual dashboards to focus on the attributes that matter most
    • Spot “Goldilocks” candidates that meet design goals and advance them faster with data-driven RNA optimization.

    Explore MPO and candidate decision-making in Signals One

    Drug Discovery for Every Modality

    Signals is the cloud software suite that accelerates drug discovery for every modality, enabling your team to confidently advance from concept to candidate.
     

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