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Explore recent and historical product updates for Revvity Signals' Cloud Native SaaS Software 

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What’s New

We are delighted to release our new version of NMR Workbook Suite™, Version 2026.

Highlighted Features

  • Export all NMR spectra in a project to a single JSON file.
  • Automatically detect non-singlet water signal.
  • Improved recognition of CHF2 signals in HSQC spectra.
  • Account for signal attenuation due to water suppression.

Administrators are recommended to subscribe to the channels within our support news site found at https://support.revvitysignals.com/hc/en-us/categories/360004446171-Support-News which contains more information about releases and other pertinent product information.

Further Details

Version 2026 adds new features including the option to export all NMR spectra in a project to a single JSON file. There are also improvements to automatic processing and analysis tools to enable accurate analysis of data for structures containing CHF2 groups and spectra with suppressed water peaks.

Data Analysis & Processing

Automatically Detect Non-Singlet Water Signal

  • You can now automatically detect water signals in spectra where water suppression techniques result in distortion of the water peak shape from the typical broad singlet. The new Allow Any Multiplicity of Water Signal option identifies a signal within the water range in the 1H spectrum that does not have a match in the HSQC 1H projection as the water signal.

Improved Recognition of CHF2 Signals in HSQC Spectra

  • You can now automatically detect and assign CHF2 peaks in HSQC spectra more accurately with improved analysis and assignment algorithms.

Account for Signal Attenuation Due to Water Suppression

  • You can now account for attenuation of signals adjacent to the water peak due to water suppression techniques to enable accurate automatic assignment. The new Adjacent Signals are Attenuated option loosens the integral restrictions for all multiplets within 0.1 ppm of the position of the water peak in the auto-assignment protocol.

Internal Standard qNMR Concentration Calculation Now Included Out of the Box

  • Internal standard qNMR calculations are now available in the interface, similar to the external standard workflow (previously available as a script provided upon request).

Conveniently Calculate Similarity Score Between Two 1D Spectra

  • You can now calculate the Hit Quality Index (HQI) between two 1D spectra of the same nucleus without the need for the reference spectrum to be in a database. This can provide a quick quantification of the match between the current sample spectrum and that of a standard.

Better Peak Handling for 19F Spectra with Strong Couplings

  • You can now automatically pick and assign peaks in 19F spectra of structures containing CHF2 groups more accurately. When the proposed structure contains these groups, the software checks the spectrum for peaks associated with a typical AB spin system for F atoms (two strongly coupled doublets with an evident ‘roof’ effect).

Expanded 1H-31P Coupling Ranges in Auto Assignment

  • You can now more accurately assign and verify structures whose spectra contain large 1H-31P coupling constants with increased upper limits for JHP. The new expanded ranges are: 

    • 3–20 Hz for 2JHP

    • 0–20 Hz for 3JHP

    • 0–6 Hz for 4JHP

Define Parameters Once for All Replicates in External Standard qNMR

  • You can now define parameters including pulse angle, scans, and receiver gain once and have them applied to all selected spectra in external standard qNMR workflows with replicates when they cannot be automatically extracted from the raw data files.

Prediction

Updated Prediction Databases

Image 1 from WN NMR Workbook Suite v2026.docx
  • You can now predict spectra based on databases with thousands more structures, chemical shifts, and coupling constants.

Accurately Predict 19F Spectra of Structures with Diastereotopic Fluorine Atoms

  • You can now predict 19F spectra with an improved algorithm that recognizes diastereotopic fluorine atoms.

Databasing

Ease of Use

  • Choose to hide the “Custom Screen Form” toolbar for greater screen real-estate.
  • You now have a new option to visualize the stereochemical configuration of select stereocenters in database records. Previously you could either display or hide all stereocenters.

Reporting

Set the Relative Height of “Median” Peak in Report

  • You can now better control the “Fit” option for dynamic Y-scaling of the 1D spectra in the reporting templates with the new Ratio parameter that allows you to specify the relative height of the “median” peak in the report.
Image 2 from WN NMR Workbook Suite v2026.docx

Use the new ratio parameter for dynamic y-scaling of 1D spectra. 
Left spectrum has a fit = 90%, right = 10%

Data Import & Export

Export All NMR Spectra in a Project to a Single JSON File

  • You can now export all NMR spectra in a project to a single JSON file.

Import Bio-Sequence Assignments from Any NMR Spectrum

  • You can now import assignments for biomolecules from any NMR spectrum in STR format.

Include Structure Information in Data Exported in JSON Format

  • You can now include structure information in records/databases exported in JSON format via .mol files.

Improved MS & Chrom Data Import

  • Improved import filters for Thermo UVPD MSn data.

Processing MS & Chrom Data

Data Analysis & Processing

Component Spectrum Flexibility

  • You can now create component spectra based on the most abundant adduct ion ([M+H]+, [M+NH4]+, [M+K]+, etc.) This is particularly useful when the [M+H]+ ion is weak or exhibits a very low intensity.

Better Handling of Peptide Structures

  • Peptides can now be displayed in a simplified form in the Table of Components, making it easier to distinguish and interpret individual structures.

Import Components without Retention Time Assignments

  • You can now use existing datafiles to generate target lists (.sdf) for more streamlined batch processing. Components can be imported with or without existing retention times, reducing erroneous assignments and enabling reuse of component files across targeted analysis and other workflows.

Display Combined Retention Time

  • You can now display the combined retention time (tR) instead of scan numbers for clearer interpretation of chromatographic data.

Databasing

Create, View, and Edit LC Simulator Files in the Database

  • You can now edit and update LC Simulator .lc7 files in Spectrus databases.
  • You can now create a Spectrus DB screen form for convenient review of LC Simulator Project records.
Image 3 from WN NMR Workbook Suite v2026.docx

Handle LC Simulator files in database view.

Reporting

Select Components for Reporting

  • You can now choose which components from the Table of Components are included in reports when using the Component/Peak Layout Organizer.

Simplified Peptide Reporting

  • You can now report peptides in a simplified form for clearer presentation in reports.

What’s New

We are delighted to release our new version of Structure Elucidator Suite™, Version 2026.

Highlighted Feature

  • Identify known structure fragments for faster elucidation.

Administrators are recommended to subscribe to the channels within our support news site found at https://support.revvitysignals.com/hc/en-us/categories/360004446171-Support-News which contains more information about releases and other pertinent product information.

Further Details

Version 2026 adds new features including the ability to identify fragments of known structures from the PubChem database prior to structure generation. There are also improvements to automatic processing and analysis tools to enable accurate analysis of data for structures containing CHF2 groups and spectra with suppressed water peaks.

Data Analysis & Processing

Identify Known Structure Fragments for Faster Elucidation

  • You can now search and identify fragments of known structures in the PubChem database that match the 13C NMR data and molecular formula entered for neutral species containing 14 or more carbon atoms. The software incorporates these fragments into User Molecular Connectivity Diagrams (UMCDs) for subsequent structure generation. This reduces the scale of this computational task and can significantly reduce overall elucidation time.

Automatically Detect Non-Singlet Water Signal

  • You can now automatically detect water signals in spectra where water suppression techniques result in distortion of the water peak shape from the typical broad singlet. The new Allow Any Multiplicity of Water Signal option identifies a signal within the water range in the 1H spectrum that does not have a match in the HSQC 1H projection as the water signal.

Improved Recognition of CHF2 Signals in HSQC Spectra

  • You can now automatically detect and assign CHF2 peaks in HSQC spectra more accurately with improved analysis and assignment algorithms.

Account for Signal Attenuation Due to Water Suppression

  • You can now account for attenuation of signals adjacent to the water peak due to water suppression techniques to enable accurate automatic assignment. The new Adjacent Signals are Attenuated option loosens the integral restrictions for all multiplets within 0.1 ppm of the position of the water peak in the auto-assignment protocol.

Internal Standard qNMR Concentration Calculation Now Included Out of the Box

  • Internal standard qNMR calculations are now available in the interface, similar to the external standard workflow (previously available as a script provided upon request).

Conveniently Calculate Similarity Score Between Two 1D Spectra

  • You can now calculate the Hit Quality Index (HQI) between two 1D spectra of the same nucleus without the need for the reference spectrum to be in a database. This can provide a quick quantification of the match between the current sample spectrum and that of a standard.

Better Peak Handling for 19F Spectra with Strong Couplings

  • You can now automatically pick and assign peaks in 19F spectra of structures containing CHF2 groups more accurately. When the proposed structure contains these groups, the software checks the spectrum for peaks associated with a typical AB spin system for F atoms (two strongly coupled doublets with an evident ‘roof’ effect).

Expanded 1H-31P Coupling Ranges in Auto Assignment

  • You can now more accurately assign and verify structures whose spectra contain large 1H-31P coupling constants with increased upper limits for JHP. The new expanded ranges are: 

    • 3–20 Hz for 2JHP

    • 0–20 Hz for 3JHP

    • 0–6 Hz for 4JHP

Define Parameters Once for All Replicates in External Standard qNMR

  • You can now define parameters including pulse angle, scans, and receiver gain once and have them applied to all selected spectra in external standard qNMR workflows with replicates when they cannot be automatically extracted from the raw data files.

Prediction

Updated Prediction Databases

Image 1 from WN Structure Elucidator Suite v2026.docx
  • You can now predict spectra based on databases with thousands more structures, chemical shifts, and coupling constants.

Accurately Predict 19F Spectra of Structures with Diastereotopic Fluorine Atoms

  • You can now predict 19F spectra with an improved algorithm that recognizes diastereotopic fluorine atoms.

Databasing

Ease of Use

  • Choose to hide the “Custom Screen Form” toolbar for greater screen real-estate.
  • You now have a new option to visualize the stereochemical configuration of select stereocenters in database records. Previously you could either display or hide all stereocenters.

Reporting

Set the Relative Height of “Median” Peak in Report

  • You can now better control the “Fit” option for dynamic Y-scaling of the 1D spectra in the reporting templates with the new Ratio parameter that allows you to specify the relative height of the “median” peak in the report.
Image 2 from WN Structure Elucidator Suite v2026.docx

Use the new ratio parameter for dynamic y-scaling of 1D spectra. 
Left spectrum has a fit = 90%, right = 10%

Data Import & Export

Export All NMR Spectra in a Project to a Single JSON File

  • You can now export all NMR spectra in a project to a single JSON file.

Import Bio-Sequence Assignments from Any NMR Spectrum

  • You can now import assignments for biomolecules from any NMR spectrum in STR format.

Include Structure Information in Data Exported in JSON Format

  • You can now include structure information in records/databases exported in JSON format via .mol files.

Improved MS & Chrom Data Import

  • Improved import filters for Thermo UVPD MSn data.

Processing MS & Chrom Data

Data Analysis & Processing

Faster, Smarter Fragmentation for Complex Peptide Analysis

Improved fragmentation algorithms enable faster processing of complex peptide samples, reducing hands-on time, and providing more comprehensive structural characterization, especially for complex cyclic peptides.

  • You can now process samples at least twice as fast as previous versions, dramatically reducing analysis time and increasing throughput for high-volume workflows.
  • You now have an additional sub-rule to allow for amide bond-reprotonatation, generating more biologically relevant "y-type" ions (Roepstorff-Fohlman-Biemann nomenclature) and improving structural confidence for cyclic peptides.
Image 3 from WN Structure Elucidator Suite v2026.docx

Amide bond reprotontation sub-rule applied to cyclic peptide fragmentation. This enhancement generates additional y-type ions by allowing proton transfer post-cleavage, improving fragment annotation and structural confidence.

  • You can now apply fragmentation across all selected components and their corresponding MS1 and MSn components and raw scans with minimal user interaction, freeing analysts to focus on other tasks while processing occurs in the background.
  • You can filter the resultant Table of Fragments by ion type (a-, b-, c-, x-, y-, z-, user-labeled, and non-labeled ions), enabling rapid identification of the most relevant fragments and simplifying analysis.

Dynamic Labeling for Cyclic Peptides

Dynamic labeling for cyclic peptides eliminates the need for manual library setup and provides flexible visualization options, accelerating structure characterization and simplifying complex peptide analysis.

  • You can now label cyclic peptides dynamically using one-letter and three-letter notations, without adding cyclic structures to the biosequence library to use cyclic peptide ion type labels—saving setup time and reducing library maintenance.
  • You can now run AutoAssignment for structures in your preferred view in either expanded (classic) or collapsed (1- or 3-letter notation)—giving you the flexibility to work in the format that best suits your workflow and interpretation needs.

Save Time with Fragment Transfer

  • You can now optionally transfer any fragment assignments directly to the query spectrum for the best hit found during an IXCR spectral search into a user-created database—accelerating structure elucidation and reducing manual interpretation time.

Improvements in Quantitation

Enhancements have been made to simplify quantitation and calibration workflows and enhance ease of use, delivering greater flexibility, precision, and efficiency. Using these features, you can now:

  • Optionally apply a weighting factor ‘1/x’ to first-degree polynomial calibration curves, enabling more accurate quantitation at lower concentration levels.
  • Add any chromatographic parameter to the calibration table, permitting configuration of a single table with all needed information.
  • View retention times and compound names as chromatographic descriptors for traces in the LC/UV/MS legend to simplify data interpretation.
  • Update the nominal amount directly from the calibration curve, without needing to restart the calibration project.
  • Re-access and edit the retention time window for the components after calculation of the calibration curve, saving time when refining calibration parameters.
  • Use Summed XICs (molecular and additional ions, that can be satellite, fragment, or adduct ions) for calibration and quantitation, providing more robust quantitation by incorporating multiple related ions.

Store MS3 Component Spectra in Spectrus DB

  • You can now store MS3 component spectra in Spectrus DB.

Improved Mass Accuracy

  • You can now set up fixed mass accuracy to calculate summed XICs. The following parameters have been introduced: 

    • XIC accuracy units = 0 (0-Da, 1-ppm)

    • XIC accuracy = 0.5 (0.5 Da is default value)

    • XIC accuracy (ppm) = 500 (500 ppm is default value)

    • Auto calculate summed XIC accuracy = True (by default we use dynamic accuracy) 

  • You can now set up mass accuracy for Isotope Pattern Calculator in ppm.

Seamless Analysis from a Wider Range of Instrument Types

  • You can now change the chromatogram type from xC/UV/MS to HPLC, GC, or CE, enabling seamless analysis of chromatography data from a wider range of instrument types.

Simplified Peak Naming

Save time and reduce errors with enhancements to peak naming when using UV peak matching tools. With these enhancements you can:

  • Automatically apply peak names across your entire dataset when using UV peak matching tools, eliminating repetitive manual labeling and ensuring consistent nomenclature.
  • Selectively retain previously assigned peak names (except “unknown”) during re-processing, preserving your work and enabling an iterative approach to data analysis without starting from scratch.

Improved Calculation and Display of Isotope Patterns

  • You can now set the mass accuracy and calculate the Isotope Pattern based on formulae for manual or Auto Assigned fragments, improving confidence in fragment assignments by providing more accurate isotope pattern matching.
Image 4 from WN Structure Elucidator Suite v2026.docx

Calculated Isotope Patterns for fragments, left shows Isotope Pattern Calculator set at 0.1 and right shows Isotope Pattern Calculator set at 1.

Improved Visualization of MS/MS Spectra

  • You now have the option to “Show Nearest or Component Related Spectra” to display all MS/MS spectra related to the selected component/precursor.
Image 5 from WN Structure Elucidator Suite v2026.docx

Visualization of three MS/MS Spectra related to the selected component.

Component Spectrum Flexibility

  • You can now create component spectra based on the most abundant adduct ion ([M+H]+, [M+NH4]+, [M+K]+, etc.) This is particularly useful when the [M+H]+ ion is weak or exhibits a very low intensity.

Better Handling of Peptide Structures

  • Peptides can now be displayed in a simplified form in the Table of Components, making it easier to distinguish and interpret individual structures.

Import Components without Retention Time Assignments

  • You can now use existing datafiles to generate target lists (.sdf) for more streamlined batch processing. Components can be imported with or without existing retention times, reducing erroneous assignments and enabling reuse of component files across targeted analysis and other workflows.

Display Combined Retention Time

  • You can now display the combined retention time (tR) instead of scan numbers for clearer interpretation of chromatographic data.

Databasing

Create, View, and Edit LC Simulator Files in the Database

  • You can now edit and update LC Simulator .lc7 files in Spectrus databases.
  • You can now create a Spectrus DB screen form for convenient review of LC Sim Project records.
Image 6 from WN Structure Elucidator Suite v2026.docx

Handle LC Simulator files in database view.

Reporting

Improvements to the Reporting Template

  • Deconvoluted mass spectra can now be added to the Report by Template along with Raw and Component spectra.

Select Components for Reporting

  • You can now choose which components from the Table of Components are included in reports when using the Component/Peak Layout Organizer.

Simplified Peptide Reporting

  • You can now report peptides in a simplified form for clearer presentation in reports.

Ease of Use

  • You can now populate the “synonym” field in the Table of Components from the same field of the database record (when available). 

  • You can now navigate directly from the Table of Components to the hit record in the database after running IXCR. 

  • Settings for IX, IXCR, and ITA are stored along with the individual processed data set/traces. 

  • “AutoAssignment Options” dialog now displays when the command “Auto Assign All Selected Components” is activated from the Table of Components. 

  • You can now re-execute a Formulae Generator for selected components (previously you could only run Formulae Generator once for All or Selected components. 

  • You can now export unassigned components from the Table of Components to an .sdf file.

What’s New

We are delighted to release our new version of Name, Version 2026.

Highlighted Feature

  • Improved name generation for mixtures of stereoisomers designated with enhanced stereochemical representation

Administrators are recommended to subscribe to the channels within our support news site found at https://support.revvitysignals.com/hc/en-us/categories/360004446171-Support-News which contains more information about releases and other pertinent product information.

Further Details

Version 2026 improves several features including name generation for structures with independent stereo groups and structure generation from such names, as well as improved naming in Japanese.

Chemical Nomenclature

Improved name generation for mixtures of stereoisomers designated with enhanced stereochemical representation

Image 1 from WN Name v2026.docx
  • Generate chemical names that indicate several stereo groups independent from one another.*
Image 2 from WN Name v2026.docx
  • Generate structures from names that define mixtures of stereoisomers with several independent stereo groups.*

* While there are no official IUPAC recommendations for definition of multiple stereo groups in chemical names, the implemented method allows for unambiguous designation of such mixtures of stereoisomers.

Improved naming in Japanese

  • Structures with alkynes and names with the 'deca' multiplier now have improved name generation in Japanese.

Improved name and structure generation

  • Generation of IUPAC recommended names for more structures.
  • Improved recognition of longer chemical names.

What’s New

We are delighted to release our new version of Spectrus Processor™, Version 2026.

Highlighted Features

  • Internal standard qNMR concentration calculation now included out of the box.
  • Conveniently calculate similarity score between two 1D spectra.
  • Better peak handling for 19F spectra with strong couplings.

Administrators are recommended to subscribe to the channels within our support news site found at https://support.revvitysignals.com/hc/en-us/categories/360004446171-Support-News which contains more information about releases and other pertinent product information.

Further Details

Version 2026 of Spectrus Processor adds new feature including built-in internal standard qNMR concentration calculation, 1D spectral similarity comparisons without a reference database, and more accurate peak handling for spectra of strongly coupled ¹⁹F nuclei. There are also improvements to NMR and MS data analysis, component handling, reporting, databasing, and data import and export.

Data Analysis & Processing

Internal Standard qNMR Concentration Calculation Now Included Out of the Box

  • Internal standard qNMR calculations are now available in the interface, similar to the external standard workflow (previously available as a script provided upon request).

Conveniently Calculate Similarity Score Between Two 1D Spectra

  • You can now calculate the Hit Quality Index (HQI) between two 1D spectra of the same nucleus without the need for the reference spectrum to be in a database. This can provide a quick quantification of the match between the current sample spectrum and that of a standard.

Better Peak Handling for 19F Spectra with Strong Couplings

  • You can now automatically pick and assign peaks in 19F spectra of structures containing CHF2 groups more accurately. When the proposed structure contains these groups, the software checks the spectrum for peaks associated with a typical AB spin system for F atoms (two strongly coupled doublets with an evident ‘roof’ effect).

Expanded 1H-31P Coupling Ranges in Auto Assignment

  • You can now more accurately assign and verify structures whose spectra contain large 1H-31P coupling constants with increased upper limits for JHP. The new expanded ranges are: 

    • 3–20 Hz for 2JHP

    • 0–20 Hz for 3JHP

    • 0–6 Hz for 4JHP

Component Spectrum Flexibility

  • You can now create component spectra based on the most abundant adduct ion ([M+H]+, [M+NH4]+, [M+K]+, etc.) This is particularly useful when the [M+H]+ ion is weak or exhibits a very low intensity.

Better Handling of Peptide Structures

  • Peptides can now be displayed in a simplified form in the Table of Components, making it easier to distinguish and interpret individual structures.

Import Components without Retention Time Assignments

  • You can now use existing datafiles to generate target lists (.sdf) for more streamlined batch processing. Components can be imported with or without existing retention times, reducing erroneous assignments and enabling reuse of component files across targeted analysis and other workflows.

Display Combined Retention Time

  • You can now display the combined retention time (tR) instead of scan numbers for clearer interpretation of chromatographic data.

Define Parameters Once for All Replicates in External Standard qNMR

  • You can now define parameters including pulse angle, scans, and receiver gain once and have them applied to all selected spectra in external standard qNMR workflows with replicates when they cannot be automatically extracted from the raw data files.

Reporting

Set the Relative Height of “Median” Peak in Report

  • You can now better control the “Fit” option for dynamic Y-scaling of the 1D spectra in the reporting templates with the new Ratio parameter that allows you to specify the relative height of the “median” peak in the report.
Image 1 from WN Spectrus Processor v2026.docx

Use the new ratio parameter for dynamic y-scaling of 1D spectra.
Left spectrum has a fit = 90%, right = 10%

Select Components for Reporting

  • You can now choose which components from the Table of Components are included in reports when using the Component/Peak Layout Organizer.

Simplified Peptide Reporting

  • You can now report peptides in a simplified form for clearer presentation in reports.

Ease of Use

Choose to hide the “Custom Screen Form” toolbar for greater screen real-estate.

  • You now have a new option to visualize the stereochemical configuration of select stereocenters in database records. Previously you could either display or hide all stereocenters.

Data Import & Export

Improved MS & Chrom Data Import

  • Improved import filters for Thermo UVPD MSn data.

 

What’s New

This latest Signals release includes updates to ChemDraw+. Highlights include coloring by element and updates to naming of mixtures. This release also includes bug fixes.

The following improvements are available for users of Signals ChemDraw. Certain features may only be available with enablement by an administrator.

ChemDraw+

  • Color by element
  • Naming of mixtures now reflects component ratios

ChemDraw +

Color by element

Selected chemical objects can now be colored by element from the Properties panel. ChemDraw+ applies a standard element color palette to the selected structure. If required, individual object colors can still be adjusted using the Properties panel for additional customization.

Naming of mixtures now reflects component ratios

Image 1 from Signals ChemDraw What's New 26.7_Sept_2026.docx

Generated names for grouped mixtures now reflect assigned component ratios more clearly. When a mixture name is regenerated, whole-number and fractional ratios are preserved so the composition is represented more accurately.

Revvity Signals™ One, including Signals Notebook, Update

What’s New

We are delighted to release our new version of Signals, 26.7.

The following improvements are available for users, administrators and developers on the Signals platform. Certain features may only be available with appropriate licensing and/or with enablement by an administrator.

  • Fundamentals
    - Register Assays and their Variants in the new Assay Library (beta)*
    - Audit trail displays highlighted granular changes for layout changes
    - Performance improvements to Parallel Experiments External Enumeration
  • AI*
    - Prompt-to-Filter is available to all systems
    - AI Explorer (Beta)
  • Data Workflows & Analytics*
    - Additional set of plate, batch and curve-based metrics
  • SAR & Decisioning*
    - Use new ChemCharts data functions to convert structures to HELM, and to calculate nucleotide and protein properties
    - Define number formatting directly within ChemCharts visualizations
  • Synergy†
    - Workflow and privilege options to allow CRO users to Close and/or Reopen their Synergy Experiments
    - Global auto-numbering controls for Work Orders
    - Work Tasks in Work Orders is available to all systems
    - Define default values, including Synergy Experiment Template, on Work Tasks Templates is available to all systems
    - Notification to Sponsor administrators when a CRO admin adds or deactivates a CRO user
    - Notification to CRO user when a Work Order is recalled
    - Publish Data Exchange Results Tables from Synergy Experiments (beta)
  • Chemistry
    - Copy individual structures from Reactants or Products tables
    - Naming of mixtures now reflects component ratios
  • Tables
    - Bucketed numerical column can be used for Categorical axis on a Box Plot*
    - Color Box Plots by aggregated numerical values*
    - Define if outliers are displayed in a Box Plot*
    - Hover over segments in Box Plots to see associated rows*
    - Add a second property to the Categorical axis of Box Plots*
    - Display secondary data of a Box Plot in a table*
    - Define a categorical column for markers in a Line Chart*
    - Trellis Charts*
  • Inventory
    - View Container Location Details in Stoichiometry and Materials tables
    - Bulk Edit Home Locations with Blank Home Location Support
    - Home Location Assignment Enhancements in Create/Edit Grid Location and Bulk Edit workflows with visual indicators and validation to ensure Home Location uniqueness
    - Improved Auto Fill Grids logic to automatically select occupied grid cells and skip only cells that are already assigned as Home Locations
    - Added row-level warning indicators in Inventory Decrement Auto Fill to clearly identify containers that are ineligible for inventory decrement
    - New Label Templates (76×25 mm (6 slots) & 62×29 mm QR)
  • InventoryGo ‡
    - Grid Position Selection During Check In/Out
    - Material ID & Expiration Date in Reconciliation Reports
    - Confirmation Prompts for Delete in Reconciliation Actions and Consume workflow
    - Reconciliation Details in Inventory Application for both Locations and Container
  • Tasks and Requests
    - Complete Task within same experiment
  • Administration
    - Access Data Factory audit events from the Signals audit log*
    - Selective export for configuration migration is available to all systems
    - A matching Configuration Report (PDF) generates based on selective configuration export is available to all systems
  • Integrations & APIs
    - Revoke Bearer tokens API
    - Expanded Chemical Structures output for Material Fetch API
    - RDF Files support for External Enumerator API 
    - Fetch Parser Definitions API
  • Xynthetica* 
    - ChemCharts access for RDKit, Percepta, and Tunelab models (beta)

* Requires Signals One license

† Requires Signals Synergy license

‡ Requires InventoryGo license

We also fixed several small bugs in this release. Details of the enhancements are described below.

The following OnDemand videos for Signals Synergy are now available

  • Configuring Initial & Ongoing Signals Synergy Needs
  • Understanding Fundamental Concepts for Signals Synergy

Data Factory Administrators should complete migration of legacy data factory projects before 27.4; after this, legacy projects will become read-only and no longer support data publication.

Data Factory administrators should also note that the Advanced Security policies in Inventa apply an “AND” logic across all user groups, restricting access if any groups lack permissions. This behavior differs from the standard Signals security model and will be fixed to align with the standard in a future release.

Developers should note that starting in the upcoming 26.8 release, fetching structure data will no longer provide the InChI property for new chemicalDrawing records. Instead, a new property, SMILES, will be provided. Please update any downstream integrations to prepare for using the SMILES field instead of InChI.

Administrators are recommended to subscribe to the channels within our support news site found at https://support.revvitysignals.com/hc/en-us/categories/360004446171-Support-News which contains more information about releases and other pertinent product information.

This content is anticipated for release on our Production E3 environments, and for Private Cloud customers on our deferred release schedule, in March 2027.

Further Details

The following improvements are available for users, administrators and developers on the Signals platform. Certain features may only be available with appropriate licensing and/or with enablement by an administrator.

Fundamentals

Image 1 from What's New 26.7_finalupdatedv2.docx
Image 2 from What's New 26.7_finalupdatedv2.docx

Performance improvements to the External Enumerator were completed. Performance for large enumerations was drastically improved.

Audit trail displays highlighted granular changes for layout changes. This feature applies to adding, deleting, moving, or renaming a page/element within experiment-like objects, tasks, requests, samples, synergy, work orders/tasks, etc.

AI

Image 3 from What's New 26.7_finalupdatedv2.docx

Prompt-to-Filter is available to all systems.

Data Workflows & Analytics

Image 4 from What's New 26.7_finalupdatedv2.docx

Additional QA/QC Metrics are now available at the level of plate wells (batches) as well as curve fits and can be visualized using the detailed views or the table view of the curve fits.

These new metrics include for each curve a Qualified Reported IC50, based on the maximum and minimum Percentage of positive Control (POC) and the respective dose associated, which can be published and used for decision making.

SAR & Decisioning

Image 5 from What's New 26.7_finalupdatedv2.docx
Image 6 from What's New 26.7_finalupdatedv2.docx

ChemChart’s Structure to HELM data function allows users to convert molecular structures from common chemical formats into HELM notation.

Image 7 from What's New 26.7_finalupdatedv2.docx

Users can now calculate nucleotide and protein properties directly within ChemCharts. Supported calculations include sequence composition, molecular weight, isoelectric point, aromaticity, extinction coefficients, and other commonly used nucleotide and protein metrics.

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Users can now configure numeric column formatting directly from ChemCharts including decimal precision, scientific notation, and other details. Formatting settings can also be applied to multiple numeric columns at once for consistent data presentation across visualizations.

Synergy

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Release 26.6 introduced the concept of CRO privileges in Synergy Configuration. This release introduces a new CRO privilege for Close Synergy Experiments. By default, the Sponsor user is responsible for closing Synergy Experiments after they are submitted by the CRO. However, there are cases where the CRO closing their own Synergy Experiments may be more efficient without compromising necessary oversight. Now, the Close Synergy Experiments privilege is granted to CRO users on a per CRO Department basis, either to all members of the Department or only CRO Department Managers.

In order to allow privileged CRO users to Close their own Synergy Experiments, the Synergy Experiment Workflows (under Synergy Configuration > Synergy Experiments > Workflows) must also be configured to (i) Allow CRO to sign and close without CRO review, (ii) Allow CRO to close without signing, or (iii) Allow CRO Department Manager to accept and close without submitting. If Allow CRO to sign and close without CRO review is enabled, privileged CRO users will be able to transition a Synergy Experiment from Active to Closed using a Sign and Close option. If Allow CRO to close without signing is enabled, privileged CRO users will be able to transition a Synergy Experiment from Active to Closed using a Close option (no signing required). If Allow CRO Department Manager to accept and close without submitting is enabled, privileged CRO Department Manager will be able to transition a Synergy Experiment from In CRO Review to Closed using an Accept and Close option, when they are assigned as a Reviewer. If all the options are enabled, all options will be available to the CRO users.

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In addition, Synergy Experiment Workflows now provides options to allow CRO users to Reopen their experiments.

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In Synergy Configuration, a Sponsor administrator with the privilege to Administer Synergy can now turn Work Order global auto numbering on or off. By default, Work Order global auto numbering is enabled; each new Work Order will take the next number in sequence, regardless of the Work Order ID sequence and regardless of the location. This is the recommended setting to ensure that Work Order naming is always unique. When Work Order global auto numbering is turned off, a new Work Order will take the next number in sequence in a given Collaboration. This allows sequential numbering of Work Orders within each Collaboration, but does not ensure unique Work Order naming. If global auto numbering is turned off, we recommend including the Collaboration Name in the Work Order ID sequence for clarity.

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Work Tasks, which can be added to Work Orders, are now available to all systems. Work Tasks create a series of trackable, assignable, and templateable sub-tasks for a Work Order. Work Tasks can be configured in Synergy Configuration > Work Orders > Work Tasks.

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Work Tasks can be associated with specific References (Reference IDs), specified Synergy Experiment Templates, and assigned to different CRO users. Note: When specifying a Synergy Experiment Template for a Work Task, Work Tasks can be added to Work Orders using Add Content or directly from a set of selected References in the Reference Table (new this release). For additional details about Work Tasks, please review What’s new content from 26.5 ad 26.6 or refer to the Help Center.

Two new notifications have been added related to Synergy. First, System and Synergy Administrators can now receive a notification when a CRO Administrator adds, removes (deactivates), or bulk uploads CRO users to their CRO. This allows the Sponsor to manage any required IdP changes (As a reminder, a CRO Administrator is a CRO user granted the Role CRO Admin. The CRO Administrator role is completely optional, but allows the Sponsor to delegate the responsibility of CRO user management to a trusted person(s) at the CRO). Second, CRO users can now receive a notification when a Work Order is recalled by the Sponsor. For both Sponsor and CRO users, notifications are configured under the User Name menu.

Chemistry

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Chemists can copy or download individual chemical structures in CDXML or other chemical formats directly from the Reactants or Products tables. This is also available in content that is not editable such as Closed experiments.

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Mixture names in ChemDraw now reflect the assigned component ratios, ensuring generated names display the actual ratio values when custom ratios are defined.

Tables

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Numerical properties can now be bucketed and used on the categorical axes of a Box Plot. A numerical property can also be used to define the colors of the Box Plot

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Box Plots can also be configured to show or hide outliers. They can also be configured to show a summary table of the statistics. The statistics table is only available for a vertical oriented box plot.

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Hovering over a quadrant of the box plot will now highlight the associated rows, and visa-versa.

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A second categorical property can also be added to the Categorical axis on Box Plots

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Markers on Line Charts can now be set by values in a categorical column. This option is only available if the Y axes are not aggregated.

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Tables can now be configured to display multiple charts, trellised via a categorical column. Configuration options include optionally setting the number of columns and setting if the trellised charts have synchronized axes.

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The user can choose to focus on a single trellised chart in more detail and iterate through the charts.

Inventory

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Added quick access to container location details directly from the Stoichiometry and Materials tables, allowing users to verify container information without leaving their current workflow.

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Bulk Edit Home Locations now supports blank Home Location values, providing greater flexibility when updating container location assignments. Users can now clear or leave Home Location values blank during bulk updates, simplifying location management and reducing manual effort.

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Enhanced Home Location assignment across Create/Edit Grid Location and Bulk Edit workflows with visual indicators and validation rules to ensure Home Location uniqueness and improve data accuracy.

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Improved the Auto Fill Grids logic to automatically select occupied grid cells while skipping only those designated as Home Locations, making container assignments faster and more intuitive.

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Added row-level warning indicators in Inventory Decrement Auto Fill to clearly identify containers that are not eligible for inventory decrement, helping users avoid errors while maintaining workflow efficiency.

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New Label Templates 76×25 mm (6 Slots)

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New Label Templates 62×29 mm QR

InventoryGo

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Users can now select a specific grid position during Check In and Check Out operations, providing greater control over container placement and improving location accuracy.

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Reconciliation reports now include Material ID and Expiration Date information, providing better traceability and supporting more effective inventory audits and reviews.

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Added confirmation prompts for delete actions in Reconciliation and Consume workflows to help prevent accidental data changes and improve user confidence.

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Reconciliation details are now available directly within the Inventory application for both locations and containers, providing greater visibility into reconciliation activities without leaving the inventory workflow.

Tasks and Requests

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Users will now have the option of completing a Task within the originating experiment assuming the user 1) has write access to the task’s originating experiment and 2) the user in question is assigned the task.

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If both of these criteria are met, the new “Use This Experiment” option will be available under the hamburger menu and the Bulk Actions menu.

Selecting “Use this Experiment” updates the Task Status to “In Progress” updates the “Experiment Link” to the same Experiment as the “Request Link” and opens up the Analyst fields for the user to update in the Task Table.

This will also allow the analyst/user to transition the Task to “Closed” from this same table allowing the user to complete their task workflow within the same experiment.

Administration

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Data Factory audit events are now accessible from the Signals Audit Log. Data Factory actions are organized by Resource Type, and can be further filtered by Resource Name and Action.

Integrations & APIs

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We have added new APIs to revoke bearer tokens via API. Bearer tokens can be revoked by email or for all users simultaneously.

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We have enhanced the Material Fetch APIs to support expanded Chemical Structures output. A new URL parameter “structureFormat” is optionally available. The structure is returned as json encoded strings.

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We have enhanced the External Enumerator APIs to support RDF files. The “Content-Type” header must best set to “chemical/x-mdl-rdfile".

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We have added a new API to fetch JSON formatted parser definitions.

The following capabilities are in beta and are available for users, administrators and developers on the Signals platform upon request. Please contact your account representative or our support team if you would like access to the following features.

Fundamentals

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The Assay Library (beta) enables organizations to register unique Assays and their associated Variants in a centralized repository. Assay and Variant metadata are captured in structured templates, helping standardize assay definitions and improve consistency.

Assays include one or more Variants, allowing users to represent planned experimental differences such as target, cell line, plate format, or other assay conditions while maintaining a clear relationship to the parent assay.

Administrators configure reusable Controlled Fields to enforce standardized terminology across assay registrations. As part of the Assay Template, these fields can also be designated for uniqueness checking.

When registering a new assay, the system automatically evaluates configured uniqueness criteria and alerts users when a potentially duplicate assay already exists.

Assays provide a structured overview of key metadata, supporting content, and registered variants within a single record.

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The Variant Summary provides a consolidated view of assay variants and their key attributes, making it easier to compare experimental conditions.

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Controlled Fields allow organizations to standardize terminology across different assay templates, which encourages better data governance and discoverability.

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When creating an Assay template, administrators must choose from the list of predefined Controlled Fields. Fields can be organized into sections for clearer organization. Configurable uniqueness checking helps prevent duplicate assay registrations by evaluating a defined combination of assay properties and alerting users when similar assays already exist.

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Once Assays are activated and a template is created, shared, and registration privileges defined, Signals One licensed users can begin to register assays. The Assay Library is available from the navigation tool bar.

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Assay and the initial Variant registration occur together.

Configurable uniqueness checking helps prevent duplicate assay registrations by evaluating a defined combination of assay properties and alerting users when similar assays already exist.

AI

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Signals AI Explorer is the AI assistant built into Signals Notebook. It helps you explore and understand your Signals Notebook data using natural language instead of manual searching.

Explorer’s Thinking panel lists every step it took to answer a question — for example, establishing who is asking, then finding that user’s experiments, notebooks and pending reviews before responding.

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Answers come back as real tables built from your records, with the highlights called out, what is waiting on you, and sensible follow-up questions offered.

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When you ask about an open experiment, the Context line lists exactly what Explorer pulled in — the experiment, the chart, and the rest of its contents.

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Explorer can build hypotheses nobody wrote a report for, laying out a mechanism-of-action hypothesis from experiment data and diagramming the pathway, with every observation linked back to the experiment it came from.

It shows its working and its doubts: building the mechanism from the same records, drawing it, and stating plainly what the data cannot yet support, with follow-up questions offered to close each gap.

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Explorer will also tell you when the data does not support a stated conclusion — for example, reading a gel table, comparing it with the recorded write-up, flagging that a ‘no contamination’ conclusion is not supported, and suggesting how to resolve it.

Synergy

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The Synergy Data Exchange is powerful feature that converts unstructured, excel-based reports from CROs into structured, columnar Results Tables ready to use in Data Factory. Under beta, Data Exchange Results Tables can now be published directly from Synergy Experiments.

To publish Data Exchange Results Tables, the administrator must first configure the specific Data Exchange Transformation for publication. In Synergy Configuration > Data Exchange > Library, select a Transformation. In the upper right, click Data Factory Mapping and then Add New Mapping.

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A map specifies which columns to publish to which Data Factory Measurement Type Attribute and is specific to a Data Factory Project and Measurement Type. First, the administrator selects a Data Factory Measurement Type for the Summary Results Table and then maps the Results Table columns (left) to the Measurement Type Attributes (right). (The system will attempt to auto-map the columns but values should be adjusted as needed.) When the map is complete, press Save Map.

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Most Transformations produce pairs of Results Tables, such as a Summary table of the calculated endpoints and a Well Details table of the individual measurements. Mapping the Well Details table is optional. The Measurement Type for the Well Details table must a be a child/details Measurement Type for the Summary table Measurement Type. When published together, these Summary and Well Details data will be automatically joined in Data Factory via the Join Value in the Results Tables.

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After mapping is complete, Activate publishing. The Transformation card will then show a green mapping icon indicating that publishing is activated.

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Note, to publish Data Exchange Results Tables, the Synergy Experiment must also be mapped and activated for publishing. To map and activate publishing for a Synergy Experiment Template, go to Synergy Configuration > Synergy Experiments > specific Template > Data Factory Mapping. Here the fields of the Synergy Experiment Template, including those which are Hidden from CRO, can be mapped to Data Factory Attributes and will be included in any publication from this type of Synergy Experiment.

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In Synergy, the Sponsor can then publish results from a Data Exchange with this Transformation. First, the Data Exchange element is added to a Synergy Experiment which is activated for publishing and the Transformation is selected. When the CRO user adds the report to the Data Exchange, the Results Tables are automatically populated. After submitting the Synergy Experiment, the Sponsor user selects the Data Factory Project for publication in the Properties (if not already selected) and presses the green Publish button in the upper right corner of the Synergy Experiment. The Sponsor is presented with all tables for publication, which may include Tables and Data Exchange Results Tables. After publication, a notification is provided and the Publication results can be reviewed under Publication in the toolbar.

Xynthetica

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Xynthetica is an AI inference feature currently in Beta. Tenants with Xynthetica beta access can now use AI models in ChemCharts to model predictive properties via Inventa.

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Users can edit in Spotfire as expected. When users select data functions, they will have access to inference models under MaaS (Models-as-a-Service).

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Users should select parameters of interest and progress will display in the lower right as the model computes.

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Calculations will appear in the table, after which users can graph conventionally.

What’s New

We are delighted to release Signals BioDesign 26.7. This release makes Gibson Assembly cloning available to all systems and includes the ability to create sequences from all cloning outputs. We have also fixed a number of smaller bugs to improve overall product quality.

The following generally available improvements are available to users, administrators, and developers on the Signals platform. Some features may require appropriate licensing and/or administrator enablement.

  • Cloning
  • Gibson Assembly combinatorial assembly available to all systems
  • Promotion of cloning outputs to sequences

Administrators are recommended to subscribe to the channels within our support news site found at https://support.revvitysignals.com/hc/en-us/categories/360004446171-Support-News which contains more information about releases and other pertinent product information.

Further Details

This section provides additional details about generally available improvements and beta capabilities included in Signals BioDesign 26.7. Some features may require appropriate licensing and/or administrator enablement.

Cloning

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Previously available as a beta release, administrators can now configure templates that allow users to design combinatorial assemblies using the Gibson Assembly cloning method. A dedicated settings section in Signals Configuration allows administrators to manage and customize Gibson Assembly configurations for their users.

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Users can design up to 1,000 molecular constructs using the Gibson Assembly method. Because the assembly is combinatorial, every sequence in Bin 1 is combined with all sequences in subsequent bins. The planner previews the total number of constructs that will be generated by the plan. For longer-running processes, users can optionally receive in-app and email notifications. When the run is complete, the Gibson Assembly provides outputs for Constructs, Fragments, and Primers. Users can inspect any warnings or errors that occur during the assembly process.

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Once the user is happy with the Gibson Assembly outputs, they may choose to take a variety of actions on them. This includes downloading output or promoting them as BioDesign Sequences. Once promoted to a BioDesign sequence, any user with access to that DNA collection can access the newly created sequences. Note that creating Gibson Assembly cloning outputs is not subject to any admin defined duplicate check rules, but promotion to sequences adheres to settings on uniqueness set by the administrators.

What’s New

We are delighted to release our new version of Signals, 26.6.

The following improvements are available for users, administrators and developers on the Signals platform. Certain features may only be available with appropriate licensing and/or with enablement by an administrator.

  • Fundamentals
    - Audit trail displays highlighted granular changes for text elements is available to all systems
    - Audit trail displays highlighted granular changes for structured tables such as hierarchical tables, variations tables, materials tables, etc. (beta)
    - Audit trail displays highlighted granular changes for worksheets (beta)
  • AI
    - Semantic Search available to all systems*
  • Data Workflows & Analytics*
    - Administrative access to Signals Native Analytics is now available to all systems
    - Curve fitting extended to Logistic regression 3-4-5 Parameters models is available to all systems
    - Initial support for custom curve fit definitions and publication is available to all systems
  • SAR & Decisioning*
    - Receive an email notification when publication to Data Factory completes
    - Track Data Factory publications with an “In Progress” status after submission
    - View very small values in scientific notation in the Material Library’s Published Data section
    - Use Insights to query, generate, and analyze Measurement and SAR Tables directly in Signals (beta)*
  • Synergy†
    - Administrative control of CRO privileges per CRO Department
    - CRO privilege to enable Copy/Copy Partial of Synergy Experiments for CRO users
    - Search Bookmarks in Synergy Advanced Search and Smart Folders for Sponsor and CRO
    - File Upload in Synergy Experiments for CRO users
    - Work Order-specific naming of Synergy Experiment Drafts
    - Sponsor can Recall Work Orders in Accepted by CRO status
    - Date Sent, Date Started, and Date Completed data on Work Tasks (beta)
    - Configuration Transfer support for Work Tasks (beta)
  • Chemistry
    - HELM string in the Products table and Sample
    - Compact display option for Chemical Check Warning watermark
  • Tables
    - Fill values in a column in an Admin Defined Table or Variation Table
    - Fill values in a column in a Hierarchical Table*
    - Disallow copy of values in a column when copying a row in an Admin Defined Table
    - Disallow copy of values in a column when copying a row in a Hierarchical Table*
    - Box Plots on Admin Defined Tables*
    - Bucketed numerical column can be used for Categorical axis on a Bar Chart*
    - Bar and Segment totals can be displayed in a Bar Chart*
    - A Second categorical column can be displayed on a Bar Chart*
    - Define segment ordering for stacked Bar Charts*
    - Multiple lines per column in a Line Chart*
    - Numerical properties displayed as aggregate on Y axes in a Line Chart*
  • Plates
    - Increase of csv upload limit from 2000 to 50000
  • Inventory
    - Bulk Update Home Locations for Containers
    - Autofill for Inventory Decrement in Stoichiometry Table
    - "Modified Date" and "Location Type" Column Added to Container Search Table and included in exported data
    - New 54 × 25 mm (QR Code) Label Template with 5 Slots
  • InventoryGo ‡
    - Grid location support for Rectification workflow
    - Activate/Deactivate default location for Auto Complete Rectification
    - Optimized Adjustment Status Control
  • Materials
    - UI update to material tables configuration available to all systems
  • Tasks and Requests
    - Increase in Task creation limit from 2000 to 4000
  • Administration
    - Audit trail displays highlighted granular changes for admin-defined tables is available to all systems
    - A matching Configuration Report (PDF) generates based on selective configuration export (beta)
  • Integrations & APIs
    - API Key Limit from 25 to 100
    - API to export Monomer Library to JSON
    - API to bulk export Containers
    - Enhanced bulk Material Export to allow specifying materials
    - APIs to fetch Report and Results tables from Data Exchange
    - Fetch Synergy Data Exchange Report and Results Tables API
    - Department assignment support via Bulk CRO User Update API

* Requires Signals One license

† Requires Signals Synergy license

‡ Requires InventoryGo license

The following OnDemand videos for Signals Synergy are now available:

  • Assays in Signals Synergy

Administrators should note that we have resolved an inconsistency in the way non global numbering currently works for Parallel Experiments, Requests, Inventa Analysis objects and In Vitro Analysis objects. These objects will now take the next number in sequence regardless of object type. The current behavior is that they take the next number in sequence for the given object type.

Data Factory Administrators should note that legacy Data Factory projects will be fully deprecated in a future release. A straightforward migration path will be provided in an upcoming release to support this transition.

Data Factory administrators should also note that the Advanced Security policies in Inventa apply an “AND” logic across all user groups, restricting access if any groups lack permissions. This behavior differs from the standard Signals security model and will be fixed to align with the standard in a future release.

Data Factory administrators should note there have been performance improvements for Bulk Delete and row-based publications.

Administrators are recommended to subscribe to the channels within our support news site found at https://support.revvitysignals.com/hc/en-us/categories/360004446171-Support-News which contains more information about releases and other pertinent product information.

This content is anticipated for release on our Production E3 environments, and for Private Cloud customers on our deferred release schedule, in November 2026.

Further Details

The following improvements are available for users, administrators and developers on the Signals platform. Certain features may only be available with appropriate licensing and/or with enablement by an administrator.

Fundamentals

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Display of granular audit trail changes within text elements are now available to all systems.

AI

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Semantic Search is now available to all systems

Data Workflows & Analytics

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Administrative access to Signals Native Analytics is now available to all systems.

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Analytics definitions for 3-4-5 Parameter logistic curve fittings are now available to all systems.

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Custom curve fit definitions and publication is now available to all systems.

SAR & Decisioning

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Users can now opt in to receive an email notification when a Data Factory publication or bulk delete action completes. The notification includes the target Project and, when available, the publication source. Multiple publication sources are supported including: Tables (e.g. ADTs), the Inventa Dashboard, and the Publish Results to Data Factory Spotfire app.

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The Publication Report for Data Factory projects now displays an “In Progress” status after a publication is submitted, confirming that the request was received. The status updates when the publication completes.

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The Material Library’s Published Data view now displays very small values in scientific notation in both Summarized and Measurement views.

Synergy

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In Synergy, most CRO privileges are managed by CRO roles (CRO Department Manager vs Department Member), Collaboration access, and Work Order assignment. This keeps CRO onboarding and offboarding simple and CRO behavior predictable. However, some privileges require Sponsor administrative control. A Sponsor Administrator with the privilege to Manage CROs and access to CROs (System Administrators, Synergy Administrators and Synergy CRO Managers) can now manage CRO privileges in Synergy Configuration > Contract Research Organizations on a per CRO and per CRO department basis.

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There are two administrator-controlled CRO privileges, Copy Entities and Copy Synergy Experiments. Copy Entities allows a CRO user to copy individual elements within Synergy Experiments, such as a Chemical Drawing, Text, or Table. Copy Synergy Experiments requires Copy Entities and allows a CRO user to Copy/Copy Partial a Synergy Experiment.

Search bookmarks allow the user to reuse common filters with a single click. In 26.5, we introduced search bookmarks in Smart Folders. In 26.6, we have extended search bookmarks to Synergy Smart Folders and Advanced Search for both the Sponsor and CRO. In a Smartfolder, a user can add a bookmark by selecting the bookmark Icon in the left corner. A specific Smartfolder will only show the bookmarks made with that Smarfolder, but all bookmarks are available in Advanced Search.

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In Synergy Experiments, CRO users can drag and drop files files, such as PDFs, images, or documents. Now, CRO users have the option to File Upload under Add Content, allowing the CRO user to load multiple files at once.

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When a Sponsor drafts a Synergy Experiment, the name is always appended with -draft. To provide additional differentiation for Draft Synergy Experiments and ensure Drafts do not consume a number in the Synergy Experiment auto-numbering sequences, Draft Synergy Experiments will be auto-named {Work Order name}-draft. If a Draft is deleted and replaced, subsequent drafts will be appended with a number independent of auto-numbering sequences (e.g., {Work Order name}-draft-1).

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Finally, the Sponsor users can now Recall Work Orders in the status Accepted by CRO. Recalling a Work Order requires Full Control (e.g., authorship or via shared access) to the Work Order. As with Recall on To Do Work Orders, recalling a Work Order removes it from the CRO and returns it to the editable Draft status for the Sponsor.

Chemistry

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Admins can now add the HELM string as a chemically aware column in the stoich grid. The admin can add a new variable property to the Reactants and/or Products table of the stoich grid. Under variable property is the new HELM String option. This property can only be used once in the table.

This HELM String property will update as the HELM structure is updated.

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The HELM property is also available in the Sample. Admins can add the property by selecting the field type Calculated Property > HELM String. As with the Stoich property, this option can only be used once.

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The HELM String property will also be available in the Chemistry autotext as is currently possible with all other stoich properties.

Admins can now utilize a compact view of the chemical check warning. This is especially useful for users working with larger molecule and HELM representations. The compact view can be enabled in the External Checking section of the Chemistry Settings. This is a tenant-wide setting.

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The compact warning display is smaller and placed near the top of the canvas to be less obstructive of the chemistry.

Tables

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Admin Defined Tables, Variation Tables and Hierarchical Tables now allow users to right-click and fill a given cell value into other rows. The user can select if they Fill Up (all rows above), Fill Down (all rows below) or Fill All. If the user has selected rows they can also fill the selected rows only.

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Configuration Administrators can also set that the values in certain columns in Admin Defined Tables and Hierarchical Tables are not copied if a user copies a row.

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Configuration Administrators can now choose to define a Box Plots on Admin Defined Tables. Similar to the definition of other chart types, administrators can define the Box Plot on the Table template including setting properties for the Categorical and Numeric axes. The admin can also choose if the end user is able to adjust the settings for the chart.

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Configuration Admins can now also define numerical values on the categorical axis of barcharts. Admins define a number of buckets for the numerical values to be segmented into. Admins can also define that bar and/or segment values are displayed on the chart.

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A second categorical property can also be used to display on the categorical axis to allow a side by side vs a stacked bar chart.

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The Configuration Admin can also define either an ordering for the segments in a stacked barchart, either by name or by value.

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Setting a Color By allows plotting of a single column of data in a Line Chart as multiple lines.

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An aggregate method can also be defined for the Numerical properties plotted on Y and Secondary Y axes of a Line Chart.

Plates

The csv upload maximum has been increased from 2000 rows to 50000 rows to better accommodate multiple large plates. Larger files may take some time to upload.

Inventory

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Users can now update the home location for multiple containers at once from the Container Search Table. After selecting containers and choosing Edit Home Location, users can either set the current location as the home location or assign a specific grid or non-grid location using barcode scanning or location search. The operation supports partial success handling, provides a downloadable CSV report containing the Container ID, previous home location, and new home location, and records all changes in the audit trail.

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The Reactants grid now includes a user-triggered Autofill feature for the Inventory Decrement column. Users can bulk-populate all rows via a header-level Autofill button or update individual rows using a row-level option. The system automatically maps the correct source value based on container unit: Sample Mass for mass-based containers and Volume for volume-based containers. Manually entered values are never overwritten, and containers in Disposed, Final Disposed, or Trashed status are excluded. Clear success/error feedback is provided, with row-specific error icons on hover for troubleshooting.

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The Container Search Table now includes additional reporting and filtering capabilities with support for both Modified Date and Location Type columns. Users can view, show/hide, filter, sort, and export these fields to quickly identify recently updated containers or locate containers stored in specific location types (such as refrigerators or acid cabinets). Both columns support header-level filtering, are included in CSV/Excel exports (and SDF exports for Modified Date), and enable more efficient reporting, auditing, and offline analysis.

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A new label template sized 54 × 25 mm is now available for container barcode printing. The label features a QR code along with 5 configurable slots that Admins can map to any container or material property via SN Config. Long location paths are intelligently truncated — displaying from the closest location upward and trimming the beginning if the path exceeds the available space.

InventoryGo

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Users can now rectify inventory discrepancies involving containers stored in grid locations. The Rectification workflow has been enhanced to support grid-based storage, allowing users to accurately select and update container locations within specific grid cells during reconciliation activities. This improvement streamlines inventory correction processes, improves location accuracy, and ensures grid location assignments are maintained consistently throughout the rectification workflow.

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The Adjustment Status control in InventoryGo has been redesigned to improve usability on smaller mobile screens. The previous button bar has been replaced with a compact ellipsis menu, reducing screen clutter and allowing more container information to be displayed without scrolling. Users can still access all adjustment actions while benefiting from a cleaner, more space-efficient interface.

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Users can now control whether a location is used as the default location for Auto Complete Rectification by activating or deactivating the setting directly on the location record. This enhancement provides greater flexibility when managing reconciliation workflows, ensuring that only appropriate locations are automatically selected during rectification. By allowing administrators to enable or disable this behavior as needed, organizations can better align auto-completion processes with their inventory management practices and location usage policies.

Materials

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The user interface for Admin configuration for materials tables in Signals Configuration has been updated and is now available to all systems.

Tasks and Requests

The maximum number of tasks has been increased from 2000 to 4000 to better accommodate workflows that require multiple tasks per sample.

Administration

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Display of granular audit trail changes within text elements are now available to all systems.

Integrations & APIs

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We have increased the API key limit from 25 to 100.

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We have added API support for exporting individual monomer libraries to JSON.

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We have added a new set of asynchronous APIs to bulk export containers as either a csv or sdf file, defaulting to csv. This follows our standard pattern for asynchronous APIs of start job, check status, and download the content. You may optionally specify a list of container barcodes to export; if not provided, it will export all containers, up to 600,000. Optionally, you may also include filters to only return containers which match the filters. 'Container Type', 'Status', 'Location', 'Content Entity Type' and 'Material Library' are currently supported filters. Lastly, you must include the set of fields, with a minimum of one, to include in the export. Barcodes, fields, and filters are all specified in the request body to initiate the export job. See the Swagger page for full details and examples.

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We have enhanced existing APIs for bulk exporting material libraries. You may now specify a list of materials, by ID, to export in the request body. If not provided, the entire library will be exported.

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We have added a new set of APIs for our Synergy product to fetch the list of Data Exchange files, the data exchange report file, and the Data Exchange results table file by table name.

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We have enhanced the bulk update for CRO users to include updating Departments when including them in a column in the bulk update csv.

Beta Features

The following capabilities are in beta and are available for users, administrators and developers on the Signals platform upon request. Please contact your account representative or our support team if you would like access to the following features.

Fundamentals

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Audit trail displays highlighted granular changes for structured tables and worksheets. The structured tables included are the following: variation tables, hierarchical tables, samples tables, materials tables, task tables, work tasks, design tables, synergy experiment tables, & sample tables. When users compare an audit record with a previous version, there is a "view granular changes" toggle. Selecting this toggle will show users a clear visual summary: gray highlighting shows text that was edited or removed, green highlighting shows newly added, and dashed boarder green highlighting indicates updated text (beta).

SAR & Decisioning

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Insights is a new Signals object (beta) that lets users query Data Factory and generate summary or SAR tables directly in Signals. After an Administrator enables the feature, users can create Insights from the Add New menu or the dedicated Smart Folder.

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When creating an Insight, users define a Data Factory query by specifying criteria for materials, measurements, or both.

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Running the query automatically generates an aggregated summary table, or SAR table, based on the selected criteria. Users can configure the table by renaming columns, controlling numeric display, adding secondary values within cells such as count, applying color options, filtering, and sorting. Some field types, including Chemical Structures, include additional formatting capabilities, such as chemical fragment highlighting. Column settings are available by right clicking the column header.

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After a query completes, Insights returns a broad set of columns. Users can choose which columns to display from the Column Selector under Show more > More Options, using search and aggregation-type filters to find the most relevant columns.

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Configuration changes are automatically saved to each user’s personal view and persist locally in the browser. Users with Write access to the Insight can save their personal view (“My View”) as the Default view for all users, supporting a consistent shared layout while preserving individual flexibility.

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From a summary or SAR table, users can right-click any cell to add the corresponding Measurement table containing the individual rows behind the aggregated result. If the measurement type has an associated Details measurement type, it is retrieved automatically. An Insight can include multiple Measurement tables for different measurement types.

Synergy

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As part of the existing Synergy Work Tasks beta feature, Work Tasks have several new properties. Sponsors often want to track how long it takes a CRO or CRO Department to perform certain tasks. Thus, Work Tasks now track the date/time the Work Task was sent (Date Sent), started by the CRO (Date Started), and completed by the CRO (Date Completed). These properties are visible on the Work Task, via search, and via API.

Finally, Work Tasks properties and templates are now supported in Configuration Transfer.

Administration

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A matching Configuration Report (PDF) generates based on the selective configuration export. When users select specific objects to export during configuration migration, a matching Configuration PDF Report will generate in an export modal based on the object selections made (beta).

What's New

We are delighted to release Signals BioDesign 26.5. This release introduces new integration with Signals Materials libraries and beta support for Gibson Assembly design. We have also fixed a number of smaller bugs to improve overall product quality.

The following generally available improvements are available to users, administrators, and developers on the Signals platform. Some features may require appropriate licensing and/or administrator enablement.

  • Signals Integration
    - Signals BioDesign is now integrated with Signals Materials libraries
  • Cloning 
    - Gibson Assembly combinatorial assembly (beta)

Administrators are recommended to subscribe to the channels within our support news site found at https://support.revvitysignals.com/hc/en-us/categories/360004446171-Support-News which contains more information about releases and other pertinent product information.

Further Details

This section provides additional detail about generally available improvements and beta capabilities included in Signals BioDesign 26.5. Some features may require appropriate licensing and/or administrator enablement.

Signals Integration

Users with a BioDesign and Signals Notebook or Signals One license can now register BioDesign sequences directly to Signals Materials. The sequence type must match the corresponding Material type. After successful registration, links are automatically created between the BioDesign sequence and the Material in both products.

Beta Features

The following beta capabilities are available to users, administrators, and developers on the Signals platform upon request. Please contact your account representative or the support team if you would like access to these features.

Cloning

Administrators can now configure templates that allow users to design combinatorial assemblies using the Gibson Assembly cloning method. A dedicated settings section in Signals Configuration allows administrators to manage and customize Gibson Assembly configurations for their users.

Users can design up to 1,000 molecular constructs using the Gibson Assembly method. They can start an assembly from the Sequences Folder or the new Assemblies folder, and assemblies can also be organized in Notebooks. After launching a Gibson Assembly, users add sequences to the Assembly planner, choose how each fragment should be assembled, adjust settings, and proceed with the assembly.

After the design is complete, the user can proceed with assembly. Because the assembly is combinatorial, every sequence in Bin 1 is combined with all sequences in subsequent bins. The planner previews the total number of constructs that will be generated by the plan. For longer-running processes, users can optionally receive in-app and email notifications. When the run is complete, the Gibson Assembly provides outputs for Constructs, Fragments, and Primers. Users can inspect any warnings or errors that occur during the assembly process.

To adjust settings and rerun the Gibson Assembly, use the Delete All Assemblies option after the run completes. This clears the generated assembly outputs so the user can revise the settings and run the assembly again.

What’s New

This latest Signals release includes updates to ChemDraw+. Highlights include a streamlined ability to create reactions on the canvas. This release also includes bug fixes.

The following improvements are available for users of Signals ChemDraw. Certain features may only be available with enablement by an administrator.

ChemDraw+

  • Streamlined reaction creation

ChemDraw+

Streamlined reaction creation

A new streamlined reaction arrow workflow is now available, which facilitates quick addition of reaction conditions and reagents when drawing reactions via shortcut keys (Ctrl/Cmd + Arrow). When used while drawing a reaction, it automatically generates aligned placeholder text boxes above and below (or beside) the reaction arrow, allowing users to seamlessly enter multi-line text and navigate between fields using Ctrl/Cmd + Enter. The text boxes dynamically adjust and maintain proper spacing relative to the arrow, ensuring reaction conditions stay cleanly formatted and associated with the reaction.