Revvity Signals

What's New

We are delighted to release our new version of Signals, 26.1. This release brings enhancements in Tasks, Materials, Data Analytics, Inventory and Tables amongst others. We have new beta capabilities around Ontologies, inherited Material properties and improving the display of tables. The beta capabilities around Contextual Lists are now available to all systems. Finally, we have also fixed a number of small bugs.

The following improvements are available for users, administrators and developers on the Signals platform. Certain features may only be available with appropriate licensing and/or with enablement by an administrator.

Fundamentals
– Ontologies integration allows terms to be used across experiments, materials, tables, and more (beta)
Data Workflows & Analytics*
– Spotfire-based workflows now integrate the Publish Results to Data Factory app
– Data Assembly download
SAR & Decisioning*
– Bulk Delete published data via the Inventa Dashboard
Chemistry
– HELM editor now supports monomer structure search
– LogP calculation now available in the Analysis panel
– Drag-and-drop of SD/RD files onto the ChemDraw canvas converts to CDXML
– Generate hairpins from oligonucleotides using the auto-pair tool
– Allowing for edits to the Material ID in the Stoich grid
– Updates to Salt Stripping to allow for fractional salts
Tables
– Contextual Lists available to all systems *
– Internal Reference type properties can be used as source for Contextual Lists available to all systems *
– Hidden columns in Tables can be temporarily unhidden
– Calculate Minimum
– Updated admin experience for Admin Defined Tables and Variation Tables (beta)
– Conditional data entry for Number properties in Admin Defined Tables and Variation Tables (beta)
Worksheets
– Contextual List property available to all systems *
Inventory
– Display barcode on Location and Container cards in inventory
– Allow admins to define autofill patterns for grid locations
– Support bulk export of internal requests
Materials
– Type in sequence registration in Materials Library
– Lineage viewer Show/Hide Properties UI update
– Inherited Properties for Materials (beta)
Tasks and Requests
– Updates to the Task Modal to facilitate different modes of task creation
Administration
– Configuration Transfer of Contextual Lists available to all systems
– Configuration Transfer of Contextual Lists in Worksheets available to all systems
Integrations & APIs
– New API to fetch Signals Version
– New APIs to support Hierarchical Tables
– Enhanced API to allow adding Assets to materials table
– New CRO APIs for file attachment and chemical compliance
– Enhanced APIs for bulk updating Containers

* Requires Signals One license
† Requires Signals Synergy license

We also fixed several small bugs in this release. Details of the enhancements are described below.

Administrators should be aware that the Normalized Compound Salt Stripping tool has now been updated to better handle fractional coefficients by altering how multi-fragment salts are interpreted from the Salt List. This change applies to registrations subsequent to this update, existing compounds will remain with the prior understanding until edited.

Data Factory Administrators should note that the syncing material library may now be changed after deleting any Data Factory projects.

Data Factory Administrators should note that legacy Data Factory projects will be fully deprecated in a future release. A straightforward migration path will be provided in an upcoming release to support this transition.

Data Factory administrators should be aware that the behavior of System Generated IDs will be updated in a future release. File-based publications will no longer support System Generated IDs.

Data Factory administrators should also note that the Advanced Security policies in Inventa apply an "AND" logic across all user groups, restricting access if any groups lack permissions. This behavior differs from the standard Signals security model and will be fixed to align with the standard in a future release.

Administrators should be aware that we will be retiring the CRAIS Checker capability from Signals Notebook and Signals One. This capability, which was only available via request, was built to allow integration specifically to the Patcore CRAIS Checker database. Such workflows have been superseded by the Chemical "External Checking" capability which can be used against any chemical compliance database. Any customers still using the CRAIS checker are encouraged to update their workflows to use this capability instead. We encourage any customers who require assistance with this transition to contact our support organization and/or engage with our Professional Services team. The CRAIS Checker capability will be retired by March 31st 2026.

Administrators are recommended to subscribe to the channels within our support news site found at https://support.revvitysignals.com/hc/en-us/categories/360004446171-Support-News which contains more information about releases and other pertinent product information.

This content is anticipated for release on our Production E3 environments, and for Private Cloud customers on our deferred release schedule, in July 2026.

Further Details

Data Workflows & Analytics

The new app allowing to publish analysis results, associated to mandatory Compound/Batches pairs, to Data Factory 2.0 is now integrated in the out of the box workflows.

The Data Assembly step of the In Vitro Analysis allows assembling the data from the instrument with multiple sources like plate format information and external lookup tables. It is now possible to download, with the click of a button, the full content of the resulting table.

SAR & Decisioning

Users can now bulk delete published data via the Inventa Dashboard. After uploading a file that contains a list of Unique Result IDs, users can choose “Bulk Delete” to permanently delete those records from Data Factory. Note: System Generated URIs must be disabled by an Administrator in order to use Bulk Delete.

Chemistry

The HELM editor now supports structure-based monomer search alongside text search, using a new 'Structure' button and preview panel in the Peptide, RNA/DNA, and Chem/Blob tabs. Structures can be pasted from common formats (cdxml, cdx, SMILES, molV2000/3000, InChI) and searched as substructure, similar, full, exact, or full including tautomers, with results returned directly in the monomer panel. Structure and text filters can be combined to refine monomer results within the active library.

LogP is now available as a calculated property in the analysis panel of the ChemDraw editor. The calculation is based on the current selection and supports structures containing fewer than 1,000 atoms or 150 heavy atoms.

SD and RD files can now be dragged and dropped onto a ChemDraw canvas and converted automatically to cdxml for continued editing.

The ‘auto-pair’ tool in the ChemDraw editor can now generate hairpins from a single oligonucleotide sequence. It identifies the region of maximum complementarity within the strand, places hydrogen bonds between complementary nucleobases, and forms a hairpin loop from the remaining unpaired nucleobases.

Users will now be able to unlink the Material ID of chemicals added via the Quick Add. Unlinking the material does not erase the chemical from the drawing. It just removes the Material ID which previously could not be removed or altered.

In an update to the behavior of the Salt Stripper for Normalized Compounds, partial salts will now be fully stripped where previously only whole salt coefficients were recognized. This will not alter the batch level chemical name, MF, or mass values as those are calculated from the unaltered batch structure. This will just allow the salt table to more accurately reflect the stripped salts

Tables

Contextual Lists are now available to systems with a Signals One license.

End users can now temporarily display hidden columns in relevant Tables even if they do not have Edit on the content the Table is in. The Cog icon will now be shown and will display in blue if hidden columns contain data. The hidden columns can be exposed from this menu. The display of the columns is transient and the table will be returned to its original state upon a page refresh. This applies to all relevant tables including Admin Defined Tables, Variation Tables, Hierarchical Tables, Design Tables, Sample Tables and Material Tables.

A Configuration Administrator can also define equations to calculate the minimum of a series of data. The functions MIN and MINOVER allow the selection of the lowest number of a set of data. If applied in a Header, the conditional minimum can be calculated using MINOVER or by nesting an IF functions within MIN.

Worksheets

Contextual List properties into Worksheets is now available to all systems with a Signals One license.

Inventory

Barcodes are now visible on both the Location and Container Card as well as in the List view within Inventory. The display order of barcodes follows the property sequence defined in Location Type and Container Type settings.

Admin users can now define grid autofill behaviour by setting up pattern mappings for Location Types. Available options include User Selection, Left-to-Right Pattern or Top-to-Bottom Pattern.

This enhancement ensures grid locations are populated according to the pattern selection configured in the Location Type settings.

Inventory users with Export Container permissions can now export Internal Requests in two formats, No Structure (CSV) or SDF.

This enhancement allows users to download and share data in the required structure for further processing or integration with other systems.

Materials

End users can now register sequence-based materials such as DNA, RNA, and Proteins and the pre-configured Plasmids library by copying in a sequence from their clipboard. A sequence string, FASTA, GenBank, and GenPept entries can be pasted in when registering materials in the smart folder.

The material lineage table Show/Hide Properties menu has been updated to more concisely display properties from various material libraries present in the viewer. Material library names now act as a header when scrolling through the list of selectable properties.

Tasks and Requests

The Task creation modal has been updated to more clearly indicate the number of tasks that will be created and allow for a single task to include all references from the Sample Bulk actions as seen below.

The Task creation modal driven from the “Add Content” menu has also been updated for greater parity to task creation from the Sample Table Bulk Actions.

Updates to the helper text at the modal to indicate the total number of tasks that will be created.

Administration

The support for Configuration Transfer of Contextual Lists is now available to all systems with a Signals One license.

Integrations & APIs

We have added a new API for querying your current Signals version.

We have added new APIs to support fetching and updating Hierarchical Tables. These APIs allow you to fetch, create, and update content of hierarchical tables.

We have enhanced our API to allow Assets to be added to the Materials Table without requiring a Batch/Lot. The request body will accept the Asset ID where previously it required a Batch ID.

We have added new APIs to bulk update Responsible Person, Amount, and Expiration Date for Containers. This will update the selected field for all Containers included in the request body. Only one of these fields can be bulk updated at a time for all Containers.

The API is asynchronous and kicked off in three steps: Create the Bulk Update Field Job -> Check the Status of the Job -> Get a report of a completed Job as a CSV.

We have added new APIs to bulk return Containers to their Home Locations. This will return all the containers to their Home locations. Only containers with a Home location set will be returned.

The API is asynchronous and kicked off in three steps: Create the Return Home Job -> Check the Status of the Job -> Get a report of a completed Job as a CSV.

We have added new APIs specific to our Synergy Product CROs for attaching files and fetching/updating chemical compliance. These allow for specific APIs to be utilized by CRO users. This enables customers External Actions to read and write for CRO users without exposing details that CROs are restricted from seeing or interacting with.

Beta Features

The following capabilities are in beta and are available for users, administrators and developers on the Signals platform upon request. Please contact your account representative or our support team if you would like access to the following features.

Fundamentals

Ontologies are now supported in Signals. Administrators may connect to most public ontologies available on either the BioPortal or Ontology Lookup Service (OLS) providers.

After connecting to an External Ontology Source, Administrators can subset a specific Ontology into a new type of Attribute List called an Ontology List.

Admins can incorporate Ontology Lists into most Templates within Signals where Attribute Lists are already supported, including Material Definitions, Experiment Templates, Table Templates, Worksheet Templates, Sample Properties, and more

When interacting with a field associated with an Ontology List, users can type-ahead to find a term directly (including matching based on synonym). Alternatively, users can select the magnifying glass icon to browse the hierarchical ontology tree.

You can now split a container into multiple sub-containers with an option to make all aliquot amounts identical. This helps save time and reduce manual entry when preparing multiple identical vials.

When printing Experiments or other objects to PDF, ontology details can be optionally included, which will embed a CSV with ontology metadata, like Preferred Name and IRI.

Tables

The administrative experience for Admin Defined Tables and Variation Tables has been updated to match Hierarchical Tables. This updated design matches that previously released for Hierarchical tables and provides a smoother experience for defining and reordering properties within the table.

Included within the administrative update described above, we have also extended the configuration of Number properties in Admin Defined Tables and Variation Tables. Number properties can be defined with conditions for data entry, ranges can be set and the property set to either not allow an out of range value, or to provide a visual indication when a value does not match.

Materials

Administrators can now configure inherited properties in all material libraries. Data field values can now be passed down (i.e. inherited) from one material to another using internal reference links. Updates to the source data are automatically propagated to any inheriting entity and are kept in sync.

What’s New

The latest release of Signals brings improvements to the ChemDraw+ application. This release brings enhancements to the drawing experience including the introduction of a new context sensitive toolbar in the drawing editor, monomer searching in the HELM editor, and highlight coloring options. Additionally, import/export support has been expanded. Finally, we have also fixed a small number of bugs.

The following improvements are available for users of Signals ChemDraw. Certain features may only be available with enablement by an administrator.

ChemDraw+

New context-sensitive ChemDraw floating toolbar
RXN file support in the ChemDraw editor
Turn on atom numbers for chemical objects
HELM editor now supports monomer structure searching
Highlight coloring now available
Notebook descriptions are now viewable in the application
Import & Export options have expanded

ChemDraw+

New context-sensitive ChemDraw floating toolbar

A context-sensitive floating toolbar is now available in the ChemDraw editor. When objects are selected on the ChemDraw canvas, a toolbar appears above the selection, displaying commonly used tools based on the selected object. As the pointer moves away from the toolbar, it automatically hides to minimize disruption to the editing process.

RXN file support in the ChemDraw editor

RXN files can now be dragged and dropped onto a ChemDraw canvas and converted automatically to cdxml for continued editing.

Turn on atom numbers for chemical objects

Atom numbers in ChemDraw can now be enabled for a selected object by selecting 'Show atom numbers' in the Atom section of the Properties panel.

HELM editor now supports monomer structure searching

The HELM editor now supports structure-based monomer search alongside text search, using a new Structure button and preview panel in the Peptide, RNA/DNA, and Chem/Blob tabs. Structures can be pasted from common formats (cdxml, cdx, SMILES, molV2000/3000, InChI) and searched as substructure, similar, full, exact, or full including tautomers, with results returned directly in the monomer panel. Structure and text filters can be combined to refine monomer results within the active library.

Highlight coloring is now available

You can now highlight atoms, labels, and bonds to draw attention to specific parts of a chemical structure to facilitate clear communication and focused presentations. This feature is available in the Colors section of the Properties panel or as a tool in the right-hand context toolbar. Choose a highlight color from the predefined palette or enter an exact hex code to create publication-ready chemical drawings.

Notebook descriptions are now viewable in the application

Notebook descriptions are now displayed in ChemDraw+ in both the Notebook List and Notebook Details views.

Import & Export options have expanded

ChemDraw+ now supports importing MOL and RXN files. When these files are brought into the application, they are automatically converted to CDXML format, enabling full editing capabilities within ChemDraw+. Additionally, export options in ChemDraw+ have expanded to include expanded MOL and SD files (V3000) as well as RXN files.

What’s New

We’re excited to introduce new enhancements that improve accuracy, performance, and flexibility across Signals ChemDraw. This release focuses on property calculations, HELM handling, and extended Python support for ChemScript. Finally, we have also fixed a small number of bugs.

ChemDraw Desktop

Properties Calculations
HELM Improvements
Support of Python 3.13.x, 3.10.x & 3.9.x

ChemDraw Desktop

Properties Calculations

LogP and Molar Refractivity (MR) calculations are now powered by RDKit, delivering more accurate and consistent results in the Chemical Properties window.

Property calculations have also been optimized for efficiency: when editing large structures with the Chemical Properties window open, updates are now queued to minimize lag and ensure a smoother editing experience.

HELM Improvements

Biopolymer cleanup has been significantly. Sequences appended to complementary strands are now properly arranged, and pendant sequences are tidied for clarity.

Leading and trailing phosphates, when omitted from a sequence, are matched with natural phosphates in the complementary strand.

Sequence selection behavior has also been improved: double-click and triple-click actions now provide intuitive selection of monomers, sequences, and groups.

Finally, the menu option Edit > Copy As HELM (Natural Analog) has been renamed to Edit > Copy As FASTA for clarity.

Python Support

ChemScript now supports Python versions 3.13.x, 3.10.x, and 3.9.x, giving developers greater flexibility for integration and automation.

What's New

We are delighted to release our new version of Signals, 25.10. This release brings enhancements in versioning, equations, Variation Tables, Inventory and Synergy amongst others. We have new beta capabilities for viewing published data from Material libraries and around calculating protein properties. We have extended beta capabilities around Hierarchical Tables and Contextual Lists. The beta capabilities around text extraction from images and publishing samples are now available to all systems. Finally, we have also fixed a number of small bugs.

Fundamentals
– Origin Template (Original Name) property for versioning
– Increase of Task creation limit to 2000
AI
–Text Extraction from Images for Signals One customers available to all systems*
–Admin options to enable/disable AI functionality in Signals One available to all systems*
Data Workflows & Analytics*
–SPR Data Import App available in Spotfire for Signals now supports Carterra file schema versions up to 10
SAR & Decisioning*
–View Published Data from Material Library (beta)
Synergy†
–Failed Status on Work Orders
–Choice of Work Order transition when submit the only Synergy Experiment
Chemistry
–Inclusion of Barcode to Internal Enumerator mapping
–Inventory Decrements from Parallel Experiments
–Context-sensitive ChemDraw floating toolbar
–Drag-and-drop RXN files onto the ChemDraw canvas converts to CDXML
–Atom numbers can now be enabled via a checkbox in the Properties panel
Admin Defined Tables, Variation Tables and Hierarchical Tables
–Calculate Number with Unit from a Number property
–Calculate Maximum
–Publish Samples available to all systems
–Updates to the Internal Reference Column Name Configuration
–Addition of Internal Reference Lookup in Variation Table
–Copy/Paste with Hidden Rows in a Variant Table
–Internal Reference type properties can be used as source for Contextual Lists (beta)*
–Search of Hierarchical Tables (beta)*
–Hierarchical table data optionally included in exported PDF (beta)*
Inventory
–Updates to Bulk Container Import
–Return Containers to Home Location
–Updates to Container Aliquot Workflow
–Create Sublocations from Parent Location
–Deleted Locations removed from Recent Locations
Materials
–Loading Measure Added to Number with Unit in Materials
–Update to Batch/Lot page
–Calculated properties for protein complexes (beta)
ELN Archive
–Preview ELN Archived Experiment Types directly in search results
Administration –Update Definition privilege
–Spotfire for Signals Custom Apps Configuration available for Private Cloud now tracks Custom App module version*
–Configuration Transfer of Contextual Lists in Worksheets (beta)
–Configuration Transfer of Hierarchical Table Templates (beta)
–Hierarchical Tables included in Configuration Report (beta)
–Contextual Lists included in Configuration Report (beta)
Integrations & APIs
–New API for exporting Orders
–New APIs to support Supplier List
–Enhanced APIs to support Supplier List Fields
–Enhanced API for Text element export
–New API to replace Chemical Drawing with a Duplex
–Enhanced API to allow expanded chemical formats for uniqueness checking
–New API to update Synergy Experiment Status
–New API to close Synergy Work Orders
–Enhanced API to allow creation of Work Orders with templates

* Requires Signals One license
† Requires Signals Synergy license

We also fixed several small bugs in this release. Details of the enhancements are described below.

Administrators should be aware that the Normalized Compound Salt Stripping tool will change to better handle fractional coefficients by altering how multi-fragment salts are interpreted from the Salt List. This change will occur in a future release and only apply to registrations subsequent to the change, existing compounds will remain with the prior understanding until edited.

Developers should note that this release addresses an issue with the GET /entities/{eid}/export endpoint, where the response returned an incorrect Content-Type header for Text entities. The header was set to text/plain, while the actual content is text/html. This only applies to text elements created through text file upload.

Data Factory administrators should be aware of several important updates. The latest version of Data Factory has officially exited beta, and all older versions of Data Factory projects and apps are now designated as “Legacy.” As part of this transition, it is no longer possible to create new legacy Data Factory projects through the user interface. We strongly encourage administrators to begin adopting the latest Data Factory features, as legacy projects will be fully deprecated in a future release. A simple migration path will be provided in a future release to support this transition.

Data Factory administrators should also note that the Advanced Security policies in Inventa apply an “AND” logic across all user groups, restricting access if any groups lack permissions. This behavior differs from the standard Signals security model and will be fixed to align with the standard in a future release.

This content is anticipated for release on our Production E3 environments, and for Private Cloud customers on our deferred release schedule, in March 2026.

Further Details

Fundamentals

A new property, called “Origin Template (Original Name)” is now captured on templated content such as ADTs, Variation Tables, Hierarchical tables, Worksheets and Experiments. This searchable property captures the name of the template used to create the item. Unlike the existing Origin Template property, which updates to reflect the current name of the Template will show the name at the time of creation. For items where the definition can be updated, the captured value will be updated if you update the definition. This allows the name of the template to be used to indicate and update the version of the definition. Note that this property is only present for content added or updated after this change.

Users will now be able to create up to 2000 tasks at a time through the task creation modal and via bulk actions. It should be noted the behavior of task creation is unchanged only the limit has been extended.

AI

For tenants with a Signals One license, users will now be able to utilize AI to extract and search by text from Images uploaded to Signals Notebook. This includes files of JPEG, PNG, and TIFF. This will apply to newly uploaded images only. Should a use load an image similar to the one below they would be able to search for it using keywords from the image like Control, Norovirus, etc.

Administrators will now be able to enable or disable new AI features utilizing the AI settings options. AI features still require a Signals One license and infrastructure to function. This just allows the admin more granular control on when these features are made available to end users. This currently only includes Text Extraction from Images for all systems

Data Workflows & Analytics

SPR Data Import App available in Spotfire for Signals now supports Carterra file schema versions up to 10.

Synergy

Sometimes a CRO is unable to successfully complete a Work Order for the Sponsor. For example, synthesis of a Design may fail, even after several successful steps or attempts, each submitted as a Synergy Experiment. Thus, at the time of Work Order submission, the CRO can alternatively submit a Work Order as Failed and provide a reason. The new Failed status is represented on the Work Order Kanban Board and included as an available External Notification.

Previously, in the case where there was only 1 Synergy Experiment for a Work Order, submitting the Synergy Experiment automatically submitted the Work Order. We now allow the user to choose how to transition the Work Order when submitting the 1 Synergy Experiment. The user can Submit the Work Order along with the Synergy Experiment, Fail the Work Order as they submit the Synergy Experiment, or do nothing to the Work Order (e.g., desire to continue adding more Synergy Experiments to the Work Order).

Chemistry

The barcode can now be mapped as part of importing SDFs into the Parallel Experiment internal enumerator along with the container ID. These values should also be visible in the stoich grids for the enumerated subexperiments.

We are now able to support Inventory Decrements from Parallel Experiments. Users may need to unhide the Inventory Decrement, Container ID and Barcode in the table:

Add New Compounds:

Containers will automatically update from Available to In Use and the Current User will update from Unassigned to the logged in user.

Scan or type the barcode into the search bar:

Add the container to the enumeration:

The container ID and Barcode will appear in the table. Users need to type in the full amount they will be removing from the container in the Inventory Decrements. This means that the user needs to know how much they will need for each sub experiment and put the total of that in the Inventory Decrement. This saves the user from having to navigate to every sub experiment to put in the Inventory Decrement:

Once the user types a value in the Inventory Decrement, the Current User, the Status and the Amount Available will be automatically updated. Users need to type in the Inventory Decrement before they enumerate the reaction:

Once the reaction has been enumerated, the Inventory Decrement column can no longer be updated:

Each sub experiment will show the Container ID and the Barcode, but not the Inventory Decrement column. This is done on purpose, so that users do not try to update the Inventory Container from a Sub experiment:

The ChemDraw editor now includes a context-sensitive floating toolbar. When content is selected on the ChemDraw canvas, a toolbar appears above the selection, displaying commonly used tools based on the selected object. As the pointer moves away from the toolbar, it automatically hides to minimize disruption to the editing process.

RXN files can now be dragged and dropped onto a ChemDraw canvas and converted automatically to cdxml for continued editing.

Atom numbers in ChemDraw can now be enabled for a selected object by selecting 'Show atom numbers' in the Atom section of the Properties panel

Admin Defined Tables, Variation Tables and Hierarchical Tables

Configuration Administrators can now define an equation to convert Numbers to Number with Unit properties. The CONVERTNUMBER function can be applied to properties of type Number with Unit. The function follows the format CONVERTNUMBER(Arg1, Arg2, Arg3) where Arg1 is an input property of type Number, Arg2 is the unit within the measure to apply to the Number. Arg3 optionally allows conversion to a different unit within the Measure.

A Configuration Administrator can also define equations to calculate the maximum of a series of data. The functions MAX and MAXOVER allow the selection of the largest of a set of data. If applied in a Header, the conditional maximum can be calculated using MAXOVER or by nesting an IF functions within MAX.

Publish Samples is now available to all systems. We’ve made an update to the Internal Reference Column Name drop down. When using the Internal Reference in configuration, the ability to refence the Internal Reference is not available for fields set to Multi-select. This has been updated to prevent misconfigurations.

If Multi-select is checked the Internal Reference is no long available to select in the Internal Reference Column Name:

Variation tables with hidden rows in the variant can be copy/pasted into. The hidden rows will be skipped over and the values will be added to the next row that is visible:

We’ve added a new Type in the configuration of the Variation Table. This is called Internal Reference Lookup. The purpose of this type is so that the administrator can configure a multi-select (from Materials already referenced in the experiment) that will put the materials into separate rows in the Variation Table.

Administrators should select the new Internal Reference Lookup from the Type drop down menu. Only 1 Internal Reference Lookup column is allowed per table so that the magnifying glass icon is associated with only one Internal Reference Lookup column. Administrator will need to select the “Limit Materials to same containing entity…” The “Show Lookup Icon…” will be automatically selected and greyed out:

When users make a new table in the experiment, they will see the magnifying glass in the top right corner of the table:

When users select the magnifying glass, they will see a list of Materials that are already referenced in the experiment. They can multi select all the Materials they would like to add to the Variation Table:

Selected Materials will be added in separate rows in the Variation Table:

Under the Property Type column Administrators can now choose Sample Properties as an option to be printed on the container labels:

We’ve made an update to the Bulk Container Import to have separate columns for the Material Library/Sample Type and the Material ID (Asset + Batch/Lot). This means that the example files have been updated and any template files that were used previously to bulk import containers, will need to be updated to have the additional column to import the data correctly:

Users can now return a series of containers to their Home Locations. Users can Search or filter for the containers that they would like to have returned to their Home Location on the Containers Search Table:

Once the containers are selected, and the Return to Home Location has been selected the containers with Home Locations will be updated. Any containers with out a Home Location will remain in the Current Location and they will be shown in the report as failures:

You can now split a container into multiple sub-containers with an option to make all aliquot amounts identical. This helps save time and reduce manual entry when preparing multiple identical vials.

Admins can now create a new sublocation directly while viewing a specific location. The parent location is automatically pre-filled in the creation form, making it faster and easier to build hierarchical location structures.

When a user selects a deleted location from the Recent options list, the system now displays a warning: “Location entry could have been trashed or may not exist. Please select a different location.”

After this warning the trashed location is removed from the Recent options list and cannot be reselected. If the user navigates away and returns, the deleted location will not reappear in Recent options. All workflows involving location selection will automatically exclude deleted locations going forward.

Materials

Admins can now utilize the measure Loading (mmol/g) for Number w/ Unit properties in Material Libraries and utilized in Sample mapping.

The Inventory Container Amount column has been moved to be next to Location:

ELN Archive

Support for previewing ELN Archived Experiment Types across all search result views

Administration

Administrators can now define if user can update the definition of tables and Worksheets. The Author privilege “Update Definition” will determine if the Update Definition option is available to users.

Signals One Private Cloud environments with Spotfire for Signals Custom Apps enabled now track module version of Custom Apps.

Integrations & APIs

We have added new APIs for exporting your Orders to a CSV or SDF file. The default value will be CSV. This is an asynchronous API flow with three endpoints to support it. First to initiate the bulk export, this requires a request body specifying the Orders you want to export and the columns you want to export. Second is to check the status of the export job. Third is to download the exported file.

We have added new APIs to fetch and update the Suppliers list. The update requires a well formatted CSV as part of the request. For convenience an example CSV is available via API.

We have enhanced APIs for stoichiometry tables, materials (assets and batches), and containers to support Supplier list field types. You will be required to specify the supplier list by the supplier ID as fetched in the new APIs. Alternatively, the Name and Country of the supplier may be used instead. Below are examples for Assets, Stoichiometry tables, and Containers using the supplier ID.

We have enhanced the entity export API to allow for Text entities to be exported as text files. This is specified using the “format” URL parameter which defaults to HTML if not specified for a text element.

We have added a new API to replace an existing chemical drawing with a paired duplex. The request body must contain two Chemical Drawing entities to be paired.

We have enhanced the API for uniqueness checking of a material to allow for additional chemical structures to be used. The content type must be specified as part of the value object for Chemical Drawing fields. InChI, SMILES, and HELM are now supported in addition to CDXML.

We have added a new API to support updating the Status of a Synergy Experiment. Synergy experiments can be updated from Active to Submitted, Submitted to Closed, Submitted to Active, and from Closed to Submitted based on the “action’ specified in the request.

We have added an enhancement to our APIs to support closing of Work Orders. This is a new action, “approve_and_close” allowed when updating Work Orders via API and transitions a Work Order from Submitted to Closed.

We have enhanced the Work Order creation API to allow for specifying a template as part of the request. It should be noted that if the Work Order template includes a template for the Synergy Experiment associated with the Work Order it will not be automatically created. To achieve this, users should use the API to create the Synergy Experiment after successful creation of the Work Order.

Further Details

SAR & Decisioning

Quickly access published data without leaving the Material Library. The new Published Data tab automatically retrieves results for the selected material, displaying aggregated values by measurement type in a summary table. Interactive tables allow users to drill down to specific measurement results.

Admin Defined Tables, Variation Tables and Hierarchical Tables

Contextual Picklists now allow the use of Internal Reference properties as the source, including IDs from Sample, Task and Material tables, and Internal Search Attribute Lists.

Search is now enabled for Hierarchical Tables. Hierarchical Table is available as an option under the Type query tool. Additionally Hierarchical Table properties are available as individual query facets.

The data from Hierarchical Tables can also now be included in the Exported PDF as an attached .csv file.

Materials

A new set of calculated properties for protein complexes is available upon request for Custom and Protein material types and in the preconfigured Antibodies library. Molecular weight, isoelectric point, extinction coefficient, and total length can now be computed for complexes comprised of multiple protein parts linked to via internal references.

Up to 20 individual protein parts can be specified per calculation.

Updates to any of the underlying protein parts are automatically checked for when viewing the complex material.

Administration

Contextual Lists and Hierarchical Tables are now supported in both the Configuration Transfer process in addition to the new Configuration Report.

What’s New

The latest release of Signals brings improvements to the ChemDraw+ application. This release brings enhancements to the drawing experience including the introduction of a new periodic table tool, object and ring fill coloring options, as well as tools for mass fragmentation and alignment. Additionally, improvements to the biopolymer editing experience with the introduction of a find and replace capability within the HELM editor. Finally, we have also fixed a small number of bugs.

The following improvements are available for users of Signals ChemDraw. Certain features may only be available with enablement by an administrator.

ChemDraw+

Created by filter now available on the Dashboard
Periodic table available in ChemDraw editor
Creation of atom lists are now possible in the periodic table tool
Chemical objects can now be copied as 'MOLV3000 (Expanded)'
'Copy As HELM (natural analog)' updated to 'Copy as FASTA'
Chemical Object colors can now be changed
Ring Fill coloring can now be applied
Mass Fragmentation tool now available
Alignment tools now available
Monomers can now be searched for, found and replaced when editing biopolymers

ChemDraw+

Created by filter now available on the Dashboard

Periodic table available in ChemDraw editor

Use the new ‘Created by’ filter on the ChemDraw+ Dashboard to control what appears in Recent Drawings. Select ‘Created by me’ to see only recently modified drawings that you created (not ones shared by other users). Select ‘Created by anyone’ to see all recently modified drawings you can access in your account.

The periodic table tool, now available in the ChemDraw toolbar, enables selection of any element to add to the canvas. When an object is selected, choosing an element from the periodic table replaces it; otherwise, any atom or blank space on the canvas can be replaced with the selected element.

Creation of atom lists are now possible in the periodic table tool

Creation of atom lists for the generation of generic structures is now also possible with the new periodic table tool. Upon opening the tool in ChemDraw, users can select List which will allow the selection of multiple elements. Once the list is generated, selecting 'Apply' will allow the user to place the atom list on the canvas in brackets.

Chemical objects can now be copied as 'MOLV3000 (Expanded)'

Chemical objects on the ChemDraw canvas can now be copied as an expanded V3000 molfile. When using 'Copy As MOLV3000 (Expanded)', a fully expanded version of the chemical object will be copied, including the expansion of all nicknames, labels, and HELM biopolymers.

Monomers are now searchable and replaceable when editing biopolymers

The HELM Editor in ChemDraw now supports finding and selecting specific monomers on the canvas for replacement. One or more monomers can be identified and selected simultaneously using the ‘Find….’ dialog in the HELM editor, and all instances found will be selected for replacement. Selecting a new monomer from the HELM editor replaces all selected monomers on the canvas with the chosen selection. This bulk find and replace capability streamlines large-scale modifications of sequences, enabling rapid transformation of a natural sequence from a FASTA string into a highly complex sequence with custom modifications.

'Copy As HELM (natural analog)' replaced by 'Copy as FASTA'

The Copy As options for HELM biopolymers in ChemDraw have been updated. The 'Copy as HELM (natural analog)' function has been replaced by 'Copy as FASTA.' This change more accurately reflects that a FASTA sequence containing all natural analogs will be copied when this option is selected, with no change in the underlying behavior.

Object colors can now be changed

Object colors can be now adjusted directly from the Colors section in the Properties panel. Choose a hue from the color picker’s pre-defined palette or enter an exact hex code for precise control when creating publication-ready chemical drawings.

Ring Fill coloring is now available

Ring fill color can be now be applied to chemical rings enabling clearer communication of ideas and concepts by directing the focus of a reader or an audience to a given part of a chemical structure. Available in the Colors section of the Properties panel, users can choose a fill color from the color picker’s pre-defined palette or enter an exact hex code to fill ring systems and create publication-ready chemical drawings.

Mass Fragmentation tool now available

A new fragmentation tool is available in the left hand general drawing toolbar in the ChemDraw editor. When used, the mass fragmentation tool mimics the Mass Spec fragmentation to generate fragment structures with calculated molecular formulas and masses.

Alignment tools now available

Structure and reaction alignment is now available in the ChemDraw editor. With objects selected on the canvas, use the right-hand context toolbar to center, align horizontally or vertically, and distribute evenly to produce clean, consistent, publication-ready figures.

What's New

We are delighted to release our new version of Signals, 25.9. This release brings enhancements in Synergy, ChemDraw, Inventory and calculations in Tables, amongst others. We have new beta capabilities for the publish of Samples from Tables and for a Configuration Report, and have extended beta capabilities around Contextual Lists and Hierarchical tables. The beta capabilities around In Vitro Analysis, Data Factory and Supplier Lists are now available to all systems. Finally, we have also fixed a number of small bugs.

Fundamentals
–Experiment description in the Grid view
–SDF export for Samples Grid view
Data Workflows & Analytics*
–In Vitro Analysis is now available to all systems
–Preview of the assembled data In Vitro Analysis is now available to all systems
–Calculations can be applied when analyzing two instrument readouts In Vitro Analysis is now available to all systems
–Re-execution of Analytics steps In Vitro Analysis is now available to all systems
–Improved error handling In Vitro Analysis is now available to all systems
–Data Factory 2.0 Publishing In Vitro Analysis is now available to all systems
–Exclusion of Plates or individual Wells In Vitro Analysis is now available to all systems
–Analytics annotations In Vitro Analysis is now available to all systems
–Audit log and history In Vitro Analysis
–Publishing enhancement, including Units publishing In Vitro Analysis
–Multiple visualization options in normalization QA mode In Vitro Analysis
SAR & Decisioning*
–Mapping useability enhancements in Publish Results to Data Factory app is now available to all systems
–Downloadable report for successful publications is now available to all systems
–Automapping improvements in Publish Results to Data Factory app is now available to all systems
–Data Factory projects now support Custom Entity data and Material Sync is now available to all systems
–System generated IDs can be used when publishing data to Data Factory is now available to all systems
–Changes to Data Factory’s information design now propagate to published data (excludes legacy projects) is now available to all systems
Synergy†
–Create Work Order from selected Designs in Designs Smart Folder Data Grid view
–Send internal Experiment content to Work Order for CRO
–Hidden from CRO properties on Work Orders
–Custom Work Types
–Work Order or CRO can be included in auto-naming Sequence Attributes for Synergy Experiments naming
Chemistry
–Name to Structure capability expanded to use ChemACX
–Periodic table tool now available in ChemDraw editor
–Creation of atom lists are now possible in ChemDraw using the periodic table tool
–Chemical objects can now be copied as 'MOLV3000 (Expanded)'
–Monomers are now searchable and replaceable when editing biopolymers
–'Copy As HELM (natural analog)' replaced by 'Copy as FASTA'
Admin Defined Tables, Variation Tables and Hierarchical Tables
–GETVALUE function to convert a Variable Measure to a Number
–Allow a function to operate on the same column if within ROWOFFSET
–Calculate the Product or conditional Product of all or some of the values in a column
–Internal Reference column limited to Materials in a Material table in the same containing entity setting available to Admin Defined Tables
–Publish Samples (beta)
–Total row limit for Hierarchical Tables (beta)*
–Header display settings for Hierarchical tables (beta)*
–Define Internal or External Data Sources in Hierarchical Tables (beta)*
–Add Inventory Columns to Hierarchical Tables (beta)*
–Internal Reference column limited to Materials in a Material table in the same containing entity setting available to Hierarchical tables (beta)*
Worksheets
–Contextual List property (beta)*
Inventory
–Map Sample Properties to Container Labels
–New labels
–Bulk Print Barcodes from Container Search Table
–PubChem Update to allow manual selection when CAS has multiple entries
–Export Material Orders
–Update to Uniqueness Rule for Reagent Material Libraries
–Container Status Filter in Location Details View
–Cancel bulk actions
–Bulk Import Containers available for all users
–System Supplier List available for all users
–System Supplier List available in new container creation workflow available for all users
–System Supplier List available in new Material Library available for all users
–System Supplier List available in Chemistry Settings Configuration available for all users
–Updates to System Supplier list
Administration
–Rearchitected SDF Projects, improved performance with row-level updates, and new methods for project creation and data publication is now available to all systems*
–Configuration Transfer of Contextual Lists (beta)*
–Configuration Report (beta)
Integrations & APIs
–API support for SMILES on Salts
–APIs for Bulk Sample Update in Sample Tables
–Users included in Sign and Add reviewers External Action
–PATCH Contextual List properties
–External Notifications for Synergy Designs
–New CRO specific APIs for interacting with ADTs, Worksheets, and Stoichiometry

* Requires Signals One license
† Requires Signals Synergy license

We also fixed several small bugs in this release. Details of the enhancements are described below.

This content is anticipated for release on our Production E3 environments, and for Private Cloud customers on our deferred release schedule, in March 2026.

Further Details

Fundamentals

Users will now be able to view the Experiment description, which currently appears on the card view, in the Grid view of the Experiments Smartfolder.

In the Samples Smartfolder, Chemical samples can now be exported to SDF from Samples Grid view by selecting “Export” in the same manner a csv export can be generated. If a selected sample does not have an associated chemical drawing, it will be skipped in the SDF export.

Data Workflows & Analytics

In Vitro Analysis and all previously released capabilities are now available to all systems.

For tenants with a Signals One license, users will now be able to perform In Vitro (screening, assays) data analysis, visualization and results quality control. The first curve fitting method available is the logistic 4 Parameter (4P) fit.

The activity in each of the In Vitro Analysis steps is now logged and appears in the history of the analysis:

The results published from a deleted In Vitro Analysis will automatically disappear from the Data Factory, in agreement with the principle of Signals constituting the single point of truth.

Concentration units, defined at the plate level, are now propagated to the results of the analysis published in the Data Factory 2.0:

In the detailed plate view it is now possible to switch the plate heatmap from raw to normalized data:

Moreover, as well as changing the visualization to the histogram view allowing to better compare the data distributions before and after normalization The histogram visualization is fully dynamic, with interactive selection and binning:

SAR & Decisioning

The Data Factory capabilities previously in beta are now fully available across all systems in Signals One. Key updates include support for row-level updates, improved performance, enhanced mapping usability, expanded publication paths, and new public APIs.

Synergy

The Designs Smart Folder Data Grid view allows users to easily manage Designs across multiple Ideas or projects. Users can now easily Create a Work Order from selected Designs in the Designs Smart Folder Data Grid view.

From inside an Experiment, a Sponsor user with the privilege to Create Work Order can now select Create Work Order and include content from the Experiment to share with the CRO. Related Work Orders created from the Experiment are captured and tracked in the Related Work Orders Table within the Experiment, while the newly created Work Order has the Experiment linked in the Originating Experiment property.

Hidden from CRO properties can now be applied to Work Orders, in addition to Collaborations and Synergy Experiments. Hidden from CRO properties allow the Sponsor to protect proprietary metadata from external partners. Synergy or System Admins can mark fields on Work Order Templates as Hidden from CRO; when a Work Order is created from these templates, only the internal Sponsor users can view and/or edit these properties and their values on the Work Order. These properties are never visible to CRO users.

The admin can now define custom Work Types for labeling and organizing Work Orders. Work Types can be marked as Shown/Hidden for simplifying user selection.

Finally, the admin can include the associated Work Order or assigned CRO in an auto-naming number sequence Attribute list in Signals Configuration. When the auto-naming number sequence is used as the Name on a Synergy Experiment Template, the associated Work Order or assigned CRO will be included in the Experiment name.

Chemistry

The Name to Structure capability in ChemDraw now utilizes ChemACX, a unified chemical database containing tens of millions of substances. This enhancement enables conversion of synonyms, trade names, and common names within the database directly to structure representations in the ChemDraw editor. This improvement can be accessed by using the ‘Name to Structure’ tool in the ChemDraw editor or pasting plain text of the structure name onto the ChemDraw canvas.

The periodic table tool, now available in the ChemDraw editor, enables the selection of an element to add to the canvas. When an element is selected from the periodic table, it can replace an atom, selection, or be added to blank space on the ChemDraw canvas.

Creation of atom lists for the generation of generic structures is now possible using the periodic table tool. Upon opening the tool in ChemDraw, users can select the ‘List’ option which will allow the selection of multiple elements. Once the list is generated, selecting 'Apply' will allow the user to place the element list on the canvas in brackets.

Selecting a new monomer from the HELM editor replaces all selected monomers on the canvas with the chosen selection. This bulk find and replace capability streamlines large-scale modifications of sequences, enabling rapid transformation of a natural sequence from a FASTA string into a highly complex sequence with custom modifications.

Admin Defined Tables, Variation Tables and Hierarchical Tables

The Function GETVALUE has been extended to allow operation on a property of type Variable Measure. The formatting remains the same, whereby the first argument defines the property being input and the second property defines the unit for conversion. Numbers within the same Measure will be converted to the equivalent number with that unit. The function can be used within a CASE statement in order to output numbers across Measures.

A limitation on self referencing of columns has been relaxed. Columns can be self referenced when within a ROFFOFFSET function, avoiding a circular reference. This allows the prior value in a column to be used to calculate the next value in the same column.

New functions to calculate the product of the values in a column have been added. PRODUCT() and PRODUCTOVER() allow calculation of the product of the values, or a conditional subset of the values, either as a column of as a Header.

Properties of type Internal Reference can now be defined to limit to “within the same entity”. This capability, already available in Variation Tables, is now extended to Admin Defined Tables. When selected the list of available references will be limited to Materials referenced in Material Tables within the same Experiment.

Inventory

Under the Property Type column Administrators can now choose Sample Properties as an option to be printed on the container labels:

In the Inventory Container Label Templates we have released 2 new label options: 20 x 12 mm:

150 x 65 mm:

101 x 50 mm:

Users can select containers on the Containers Search Table that they would like to print/re-print barcode/labels for. Select the containers using the checkboxes to the left and choose the Print Barcode option:

The select barcode label size window will appear:

There has been a PubChem update to allow manual selection when CAS has multiple entries. When a given CAS has multiple entries associated in PubChem, the users will now get an option to select which entry they would like to pull the data into the Reagent Library:

Users will see a modal appear when they choose to update the data from PubChem to select from:

Once an option is selected, the data will be updated in the Regent Library:

In the top right corner of the Material Orders page is the new Export Order option:

Users can choose to export as a csv or a SDF:

Reports can be found in the Inventory Bulk Reports  Material Reports  Material Order:

There has been an update to Uniqueness Rules for Reagent Material Libraries. Administrators can select 1 additional required field for uniqueness checking for Reagent Libraries:

This means that when a new Reagent is being created the Structure is checked first, then the CAS number and if both Structure and CAS are empty, the chosen Other Field is used for uniqueness. Users will see the Resolve Duplicates screen if a match is found:

An additional Container Status Filter has been added in the Location Details View. This allows users to choose to see Disposed, Final Disposed, Exhausted containers instead of the default In Use and Available that the page defaults to:

When users initiate an action or a bulk download from the Containers Search Table or from a Move Location Contents or a Move Location, they are now able to cancel the request by navigating to the Inventory Bulk Reports page and choosing the Cancel Job icon:

Please note that some actions are very quick so the Cancel Job option may not appear to work or may not be present at all since the job runs so quickly. Bulk Import Containers is now available for all users:

Please remember that users need the permission to create containers in order to bulk import containers.

System Supplier List is available for all users. In addition, there are a few updates to System Supplier List. Inventory Administrators will see the System Supplier List available in the Inventory Settings page:

Inventory Administrators will be able to sort the System Supplier List by ChemACX or Admin Defined. The sort will keep the Favorite Suppliers at the top of the list and will sort those first and then sort the rest of the Suppliers below:

Integrations & APIs

We have updated our fragments APIs to allow for fetching and updating the SMILES values for Salts.

We have added new APIs to bulk update Samples in a samples table. This is an asynchronous API with two new endpoints. One to kick off the request and one to check the status (Success or Failure). The request body of the first PATCH request requires a well formatted CSV with the first column representing the ID of the sample and the subsequent the properties to be updated.

We have enhanced the External Action for “Sign and Add Reviewers” and “Sign and Add Two Stage Reviewers” to include the selected reviewers in the External Action request body. This is only applicable when submit method is set to POST.

We have enhanced our APIs to support Contextual List fields and columns. This applies to APIs for updating Admin Defined Tables, Variations Tables, and Worksheets. Note that using the External API any text value can be entered into these fields/columns regardless of the contextual list definition.

For our Synergy product we have added External Notifications for Design signing Events. These are included in the Notification Trigger “All Signing Events”.

We have expanded the APIs for our Synergy Product CROs to include Admin Defined Tables, Worksheets, and Stoichiometry. These allow for specific APIs to be utilized by CRO users. This enables customers External Actions to read and write for CRO users without exposing details that CROs are restricted from seeing or interacting with.

Further Details

Admin Defined Tables, Variation Tables and Hierarchical Tables

Publish Samples is a new beta feature. To publish Samples for analysis the configuration will need to be done in at least 2 places and up to 3 depending on where the information is being filled stored or entered. The simplest option is to configure the Sample Template and the Table Template (ADT or Variation Table).

To configure the Sample Template the administrators needs to navigate to the System Objects  Samples  Templates. Choose the Template for the Samples to be published and click the Data Factory Mapping in the top right corner:

Select the Data Factory Project that the Sample data will be published to and click Save and Continue:

For the map to be able to be filled out, the Data Factory Entity Type needs to be selected. Administrators can map the Sample to the Asset or to the Batch/Lot. This is where the configuration depends on where the data will be stored or entered. Administrators can configure the system so that every Sample is an Asset is Data Factory and then associate Variants in a Variation Table as the batch/lots OR a configured field in an ADT can be the batch/lot. Another option the administrator could configure is the Experiment ID as the Asset (or another field on an Experiment/ADO, ex: a Material ID that links back to a Materials Library) and map each Sample as a batch/lot of that ID.

Once the administrator chooses the Data Factory Entity Type, either the Compound ID (if Asset is chosen) or the Batch ID (if Batch/Lot is chosen) the value will automatically fill in the ID row. The ID is expecting an Internal Reference. This means that in the ADT/Variation Table there is expected to be an Internal Reference field that will be filled in (by the user) with a viable Sample ID from Signals Notebook:

Configure any additional entity fields that should be associated with the Sample creation as an entity and Save the map (ex: Purity). Next the administrator should configure the Experiment/ADO template if that is where the asset or any additional should be entered by the user (ex: Date, Scientist…):

After the Experiment/ADO is configured, the ADT or Variation Table where the Samples and the data to be published will be entered will need to be mapped:

If the Asset is in the table, it can be mapped as well. When all the mapping is done then the users will be able to publish the data from their experiments:

The report will be available with the Status once the publication is complete:

Note: Setting up the Data Factory Entity and Measurement Types before configuring Signals Notebook will help ensure a smoother process. Starting with configuring the Experiment/ADO, then Sample Template and then ADT/Variation Table can help with keeping track of the least detailed mapping to the greatest detailed mapping. Administrators should remember to enable the publishing before leaving the configuration of each Template. Samples as the Asset with the Batch/Lot as the Variant Name Samples as the Asset with the Batch/Lot as an additional field in the ADT/Variation Table Experiment/ADO as the Asset and Samples as the Batch/Lot Experiment/ADO additional field as the Asset and Samples as the Batch/Lot Samples as the Batch/Lot with an additional field in the ADT/Variation Table as the Asset Experiment/ADO (or additional field) as the Asset and Variants as the Batch/Lot- if you choose this method be sure that the Variant is configured to be unique for every Variation Table the user may add to the Experiment (ex: Add the Table Name to the Variant)

A total row limit of 2000 rows has been applied to Hierarchical Tables. This limit is applied across all of the table layers.

Administrators can now define properties for display of the headers. Headers are displayed in consecutive vertical blocks of up to four, a maximum number of headers in each block and a definable maximum width of the labels and values.

External and Internal Data Sources can now be applied to the table layers in Hierarchical Tables. Each table layer can have up to one data source applied.

If the data source is an appropriately configured Internal Data Source, Inventory columns can optionally be added to a single data layer. This will add the barcode lookup capability to the ID column, along with Barcode, ContainerID and Inventory Decrement columns.

Properties of type Internal Reference can now be defined to limit to “within the same entity”. This capability, already available in Variation Tables, is now extended to Hierarchical Tables. When selected the list of available references will be limited to Materials referenced in Material Tables within the same Experiment. An additional column of type Variable Property can be added to add the Material Name.

Worksheets

The Contextual List property type has been added to Worksheets.

Administration

Contextual Lists are now included in Configuration Transfer.

This release brings the beta release of a System Configuration Report. This feature allows the generation of a PDF that captures the current configuration settings for a tenant. The Configuration Report is accessed from the Export Configurations dropdown.

What's New

We are delighted to release our new version of Signals, 25.8. This release brings enhancements in our Data Workflows and Analytics, SAR and decisioning, Inventory, Tables and Plates amongst others. We have new beta capabilities for Hierarchical Tables, Contextual Lists and extended beta capabilities around Supplier Lists, Data Factory and InVitro Analysis. Finally, we have also fixed a number of small bugs.

AI
–Admin options to enable/disable AI functionality in Signals One (Beta)
Data Workflows & Analytics
–Animal Selection & Group Assignment App with Randomization capabilities is no longer available
–Data Factory 2.0 Publishing (beta)
–Exclusion of Plates or individual Wells (beta)
–Analytics annotations (beta)
SAR &Decisioning
– System generated IDs can be used when publishing data to Data Factory (beta)
– Changes to Data Factory’s information design now propagate to published data (excludes legacy projects) (beta)
– ChemCharts manual sequence alignment visualization, HELM enhancements, and structure visualization improvements
Synergy
– Copy/Copy Partial of Work Order
– Bulk create Designs from enumerated Products in Parallel Experiments
Chemistry
– Drawing of individual RNA or DNA monomers is now supported in the HELM editor
– Selection and replacement of multiple monomers at once when using the HELM editor is now possible
Admin Defined Tables & Variation Tables
– ROUND function
– Hierarchical Tables (beta)
– Contextual Lists (beta)
Plates
– Load/update plate via CSV upload
Inventory
– 3 New labels
– Update to Export Containers for searches that return no results
– Additional Container Privilege for updating Home Location
– Search by CAS and select containers in Quick Add in Chemical Drawings
– Remove link to any container in the Materials Table
– Bulk Import Containers (beta)
– Update to Advanced Search for Home Locations with grid coordinates
– System Supplier List available in Chemistry Settings Configuration (beta)
Materials
– Option to utilize structure AND additional fields in uniqueness checking
– Total Cysteine Content (%) for protein sequences
Adminstration
– Privilege to create or use personal templates
– Privilege to copy experiments or entities
Integrations & APIs
– Enhanced APIs to allow RXN files for export and replacement of Chemical Drawings
– API enhanced for adding items to Stoichiometry grids without Chemical Structures
– New APIs for moving location content to a new location
– New API to create relationship links between entities
– API enhanced fetch all samples from a Samples Table
– New APIs to fetch and update Order details
– External Notifications for Work Orders
– New CRO specific APIs for interacting with Entities and Samples

We also fixed several small bugs in this release. Details of the enhancements are described below.

Developers should note that we are planning to address an issue with the GET /entities/{eid}/export endpoint, where currently the response returns an incorrect Content-Type header for Text entities. The header is currently set to text/plain, while the actual content is text/html. This only affects text entities created through text file upload. This will be corrected in an upcoming release.

Data Factory administrators should be aware that in an upcoming release you will no longer be able to create Legacy Data Factory projects. We encourage adopting the Data Factory beta features which will soon replace the current (legacy) projects.

System Administrators of E3 or Private Cloud systems using our validation ready deferred release should be aware of the upcoming change to our patch process. Starting November 2025, we will introduce a planned patch to E3 and select Private Cloud environments approximately 3-4 weeks after the update to Production. These patches will contain resolution to critical issues identified late stage during PQ testing or immediately post-Production. Note: These critical issues can include those not identified via a Sandbox tenant that were not fixed in sufficient time in our Standard releases to be part of the Production update. If no appropriate issues are identified, no patch will be released. The planned timing for the patch will be communicated in the Release Notes.

Administrators should note that the beta capability “Animal Selection & Group Assignment App with Randomization capabilities” is no longer available.

Administrators should be aware that the stereochemical annotation of pseudochiral OR centers using the guided stereo tool now will add an additional label which is interpreted as chemically significant. This change only applies to annotations made subsequent to this change, existing compounds will remain with the prior understanding until edited.

Data Factory administrators should be aware that you can no longer change the data type of an attribute to an incompatible format (e.g.: from chemical structure to date).

Data Factory administrators should be aware that secondary (AER) maps will now only be handled by the Data Factory backend. You can no longer create nor modify these maps manually. Consequently, the following are breaking changes in Primary APIs:
GET /information-design-service/import-maps/{importMapId} no longer returns secondary maps
POST /information-design-service/import-maps/search no longer returns secondary maps
POST /information-design-service/import-maps no longer allow the creation of secondary (AER) maps. This will return a 400 error if attempted. Query parameters and response fields related to secondary maps have been removed.

The following endpoints will no longer return fields related to secondary maps:
PATCH /information-design-service/mtypes/{name}
GET /information-design-service/mtypes/{name}
The following endpoints have been marked deprecated and will no longer include fields related to secondary maps:
GET /information-design-service/attributes/{attributeId}
POST /information-design-service/mtypes
PUT /information-design-service/attributes/{attributeId}

This content is anticipated for release on our Production E3 environments, and for Private Cloud customers on our deferred release schedule, in March 2026

Further Details

SAR & Decisioning

The ChemCharts “Manual Sequence Alignment Visualization” allows users to manually align biological sequences (including HELM). Drag to align single or multiple residues and modify gaps as needed.

The ChemCharts HELM visualization introduces a handful of customer-requested helper data functions.

Convert biosequence formats using the BILN to HELM data function.

Extract all monomers or monomer units from HELM into a set of columns

Perform HELM substructure or similarity searching using a powerful graph-based comparison of query structure and target structures.

Optionally use a local data table as a monomer source

ChemCharts now supports SVG image format within Table/Gallery visuals, and the Embed Image data function.

There are minor enhancements to the Kinome, Chemistry, Gallery, and Table ChemCharts

In the Kinome visualization, optionally use column names as node labels.

In the Table visualization, there is a new visual indicator for columns with a shadow column assigned.

The Chemistry visualization now supports defining a default structure column, enabling/disabling tooltips for structure search images, specifying the image size in structure searches, and importing/exporting structure searches

Gallery visualizations can now be exported to PDF

Antibody and Nanobody data functions, including Developability Dashboards, now support the ABodyBuilder v3 model

Use the new “Extract Sequence from GenBank” data function to output the sequence into a new column.

Synergy

Sponsor users with the new privilege Clone Entities can Copy or Copy Partial Work Orders. This allows the Sponsor to easily send the same compounds for another assay or easily repeat common Work Orders.

After enumerating Products in a Parallel Experiment in Signals, a Sponsor may want to synthesize the products internally or send the Products off to a CRO for synthesis. On a Sub-Experiment/Products Table in a Parallel Experiment, a Sponsor can now Bulk Create Designs. Created Designs are marked with the Originating Experiment for traceability and are easily sent off in a Work Order for synthesis at a CRO.

Chemistry

Support for drawing individual RNA/DNA monomers has been added to the HELM editor. When editing in the RNA/DNA tab of the HELM Editor, there is a new "None” option available in the dropdown menu for secondary monomers. When “None” is selected, a monomer of that type will not be drawn when the primary monomer is added to the ChemDraw canvas. Additionally, if the user wishes to draw using only the primary monomer (ribose, base or phosphate), a modifier key is available. Selecting alt/option + the monomer will only add the primary monomer to the canvas.

Bulk selection of monomers while in HELM edit mode is now possible by using the 'Shift' key and selecting multiple monomers on the canvas. Once selected, these monomers can be replaced simply by selecting a new monomer in the HELM editor.

Admin Defined Tables & Variation Tables

A new function “ROUND” is available in table calculations, to supplement our exiting ROUNDUP and ROUNDDOWN functions. ROUND uses the method “Rounding half away from zero”, an optional second argument allows definition of which position relative to the decimal point the value is rounded to. If the second argument is absent, the value is rounded to the nearest whole number.

Plates

Users are now able to load or update Plates via a csv upload by selecting “Update plates from csv”.

This brings up a mapping modal which allows the user to map columns from their csv to the associated annotation layers.

Once imported the plate is updated.

Inventory

3 New Labels:
25 x 18 mm:

12 x 12 mm:

89 x 25 mm:

Update to Export Containers for searches that return no results. If the data changed during the export the job would not finish, Users will now see a failure message on the page:

And on the report page:

Additional Container Privilege for updating Home Location. Now users can be given the privilege to update a container’s Home Location. Previously this was reserved for System and Inventory Administrators. Users still need security access to the containers as well as Edit Container privilege to update the Home Location:

Once the user has the privilege to update the Home Location, they can use the vertical 3 dots in the top right corner to open the Edit menu:

Search by CAS and select containers in Quick Add in Chemical Drawings. When users type a CAS number in the Quick Add, associated containers will show as an option:

Users then select the container they would like to add to the Chemical Drawing:

Remove link to any container in the Materials Table via the unlink icon:

Update to Advanced Search for Home Locations with grid coordinates filter:

Users can select a location with a grid coordinate to find which container is supposed to be in that location:

Materials

Admins now have the option of utilizing both the structure rules AND material fields in uniqueness checking during material registration.

This is an addition to the existing OR option for uniqueness checking. If AND is utilized, a duplicate will only be identified with there is a match on the Structure AND all selected rules.

These options are deactivated if the Structure rules are turned off as all fields will be utilized regardless of selection.

Calculated total cysteine content (%) is now available for Protein materials.

Administration

Admins can set a privilege to control users’ ability to copy experiments or entities. The “Clone Entities” privilege allows users to copy and partially copy experiments, and content entities within an experiment. Disabling this privilege from all roles for a user will disable the their ability to copy content.

Admins can also set a privilege to control users’ ability to save or use personal templates. When the “Save as Template” privilege is disabled for users they cannot save nor use Personal Templates.

When admins disable both the ‘Clone Entities’ and ‘Save as Template’ privileges, end users are forced to use the latest definition of a system template when creating an experiment.

Integrations & APIs

We have updated our APIs to allow for exporting and replacement of Chemical Drawings with RXN files. A replaced Chemical Drawing will maintain the entities ID while replacing the content from the provided RXN file.

We have added new APIs for adding custom products and reactants to Stoichiometry grids. This enables the ability to add either a product or reactant to a stoichiometry table without need of a chemical structure.

We have added new APIs for moving location content to a new location. This will move all the containers in a location to another location. You will need to provide an option for handling duplicates as part of the request.

The API is asynchronous and kicked off in three steps: Create the Move Content Job -> Check the Status of the Job -> Get a report of a completed Job.

We have added a new API to create relationship links between entities. The type of relationship: related, repeats, repeated_by, duplicates, duplicated_by, precedes, or preceded_by is required for creating the link.

We have updated our API to allow fetching all Samples in a Samples Table.

We have added new APIs to fetch and update Material Orders.

For our Synergy product we have added External Notifications for Work Order signing Events. These are included in the Notification Trigger “All Signing Events”.

We have added new APIs specific to our Synergy Product CROs. These allow for specific APIs to be utilized by CRO users. This enables customers External Actions to read and write for CRO users without exposing details that CROs are restricted from seeing or interacting with

Further Details

AI

Data Workflows & Analytics

It is now possible to define the mappings of the raw data and curve fit results with the Measurement Types of a Data Factory 2.0 project in the In Vitro Analysis templates.

In addition to the raw data and curve fit results, which are interrelated, a set of general properties can also be mapped for publication.

The users of an In Vitro Analysis template with publishing activated can decide whether both raw data and curve fit related tables or only one of them should be published for their analysis.

In addition to the exclusion of curves and curve data points, it is now possible to exclude whole plates or plate wells from normalization.

The exclusions at the plate or well level affect the normalization and the curve fitting downstream. Therefore, the users are notified that they should recalculate the normalization results.

Successively, downstream steps dependent on the normalization, like the curve fitting, will also need to be recalculated and the user gets another notification.

Plate, well, curve and point-level annotations are now embedded in an In Vitro Analysis.

All the annotations can be reset and result recalculated in a row by clicking on the global RUN button, while the recalculate buttons maintain the annotation.

SAR & Decisioning

System generated unique result IDs are now available for use with Data Factory (beta) projects in Signals One. When enabled by an Administrator, unique identifiers will be automatically generated for any empty ID values during publication, while preferentially using any explicitly provided identifiers. This feature does not apply to legacy projects.

Data Factory will now propagate changes in entity, attribute, or measurement type design to maps and published data. When making a change to the information design, administrators will be warned if the change will require data reprocessing. Once an admin makes a change requiring data reprocessing, newly published data will be inaccessible until after the admin selects “Reindex Now”, and data finishes processing. When reindexing, all design changes are applied to any existing data or newly published data. Any existing admin-defined maps will continue to work.

When an admin has made changes that require data reprocessing, end-users will see a “New Data Pending” notice, indicating that access to newly published data may be delayed. Previously published data will remain accessible during this time. The label is removed once data finishes processing.

Admin Defined Tables, Variation Tables and Hierarchical Tables

A new tabular content type, Hierarchical Tables, has been added. Hierarchical Table Templates can be defined by an administrator in the Table Templates folder. Hierarchical Tables can contain multiple table layers, with association between an upper row in a table and one or more rows in the lower table, to provide layers of data containing different levels of detail. Hierarchical Tables require the end user to have a Signals One license.

The association between rows can be indicated with “propagating down” an identifier value from a row above. Rows from multiple associated upper rows can be displayed, to add rows however a single parent must be selected.

Available property types include a similar library to in Admin Defined Tables, such as Text, Number, Date/Time, Internal Reference etc. Equations in a table layer or between table layers, or Headers, can be defined. Number properties can also be defined with conditions for data entry, ranges can be set and the property set to either not allow an out of range value, or to provide a visual indication when a value does not match.

A new property type, Contextual Picklists, have been added to ADTs, Variation Tables and Hierarchical Tables. Contextual Picklists allow an administrator to define a logic for generation of a dropdown list, where the values for the list are sourced from other content within the system. This capability is only available to users with a Signals One license.

The source of the list can be defined as coming from the Experiment the user is in. The source is further defined as to the content type, such as an Admin Defined Table. Depending on the content type, the source is further refined to identify the Origin Template. Finally, the Property where the values are found is defined. A dropdown list of the unique values, given the prior definition, is presented to the end user as a dropdown.

The source for the list can also be defined as a different Experiment or similar object (Admin Defined Object etc.) The other Experiment must be defined in the table with an Internal Reference type field.

In addition to choosing data from table type objects, the values in the list can also represent the names of the content items within an Experiment by selecting the option “Experiment child elements”.

The values in the list can also represent the Variant Names from Variation Tables to aid in associating testing or other data on those Variants by selecting “Variant Names” after selecting the Variation Table and Origin Template.

Inventory

Bulk Import Containers into Inventory. Users need to navigate to Inventory, to the Add New menu:

Select a Container Type to activate the Example download and the File Upload:

A csv example file will be created based on the container type properties:

Users need to be able to create containers and have (at least) read access to locations to import containers:

Once the import is started, the progress will be displayed at the bottom of the screen:

When the import is complete a report will be created. If there are any errors, they will appear in the report and the containers with errors will not be created.

Once complete, the users will be brought to the containers search table with the filter pre-set for the date:

System Supplier List available in Chemistry Settings Configuration. Navigate to the SN Config Chemistry Settings to create a column using the System Supplier List option:

Users will see the column in the stoichiometry table with the favorite suppliers at the top of the alphabetical list:

What’s New

The latest release of Signals brings improvements to the ChemDraw+ application. This release brings enhancements to the structure to name capabilities in the application. We also have new improvements to increase the efficiency of drawing biopolymers in ChemDraw. Finally, we have also fixed a small number of bugs. The following improvements are available for users of Signals ChemDraw. Certain features may only be available with enablement by an administrator.

The following improvements are available for users of Signals ChemDraw.

ChemDraw+

Name to Structure capability expanded to use ChemACX
Drawing of individual RNA or DNA monomers when editing biopolymers
Selection and replacement of multiple monomers at once in biopolymers

ChemDraw+

Name to Structure capability expanded to use ChemACX

Converting names to structures in ChemDraw+ now utilizes the ChemACX, which is a unified chemical database containing 10s of millions of substances. The use of ChemACX now allows the conversion of synonyms, trade names or common names of the substances within the database to a structure.

Drawing of individual RNA or DNA monomers when editing biopolymers

Support for drawing individual RNA/DNA monomers has been added to the HELM editor. When editing in the RNA/DNA tab of the HELM Editor, there is a new "none' option available in the dropdown menu for secondary monomers. When 'None' is selected, a monomer of that type will not be drawn when the primary monomer is added to the ChemDraw canvas. Additionally, if the user wishes to draw using only the primary monomer (ribose, base or phosphate), a modifier key is available. Selecting alt/option + the monomer will only add the primary monomer to the canvas.

Selection and replacement of multiple monomers at once in biopolymers

What’s New

The latest release of Signals brings improvements to the ChemDraw+ application. Basic chemical properties of structures and biopolymers can now be selected for addition to a drawing from the Analysis panel. Additionally, hydrogen bonded fragments are now recognized as a single structure. This release also includes several bug fixes, further improving the overall user experience.

The following improvements are available for users of Signals ChemDraw.

ChemDraw+

Enhanced property selection control when adding to drawings
Hydrogen-bonded fragments are treated as a single structure

ChemDraw+

Add selected chemical properties to the ChemDraw canvas

The Analysis panel now offers improved flexibility when adding chemical properties to drawings. Users can now choose which properties to add to their drawing when using the 'Add to Drawing' button located at the bottom of the Analysis panel. Selecting this button now opens a window where properties can be selected to be pasted onto the canvas.

Hydrogen-bonded fragments are treated as a single structure

Hydrogen bonded fragments in ChemDraw will now be recognized as a single structure with properties such as molecular weight, molecular formula and exact mass being calculated accordingly.

What's New

We are delighted to release our new version of Signals, 25.7. This release brings enhancements in Signals Synergy, our ChemDraw sketcher, Tables, Samples, History, Inventory, Plates and Materials. We have new beta capabilities enabling Semantic Search and extended beta capabilities around the in vitro analysis object, updated data factory and supplier lists. Finally, we have also fixed a number of small bugs.

Fundamentals
–The audit trail for System Templates and Experiments captures the previous and current versions of Layout Changes for actions including Rename Page, Add Page, Delete Page, & Reorder Page
–The “Updated User” audit record within the Admin Audit Trail displays current and previous versions of the specific changes to User metadata
AI
–Semantic Search (beta)
Data Workflows & Analytics
–Preview of the assembled data in Vitro Analysis (beta)
– Calculations can be applied when analyzing two instrument readouts in Vitro Analysis (beta)
– Re-execution of Analytics steps in Vitro Analysis (beta)
– Improved error handling in Vitro Analysis (beta)
SAR & Decisioning
– Inventa Analysis SAR Groups preview can now be filtered by Data Factory project
– Integrated Summary App now supports well-level details within the combined unsummarized table.
– Target Engagement Profiler now uses “continuous” as the default x-axis
– Data Factory projects now support Custom Entity data and Material Sync (beta)
Synergy
– Bulk fill values in Reference Tables for selected rows
– Sharing of batch salt information to CROs in Reference Tables
– Status Modified field and filter for Designs and Work Orders
– Notifications for internal users and groups assigned to Designs
Chemistry
– View basic chemical properties in the Analysis panel
– Add chemical properties directly to the ChemDraw canvas
– Hydrogen-bonded fragments are treated as a single structure
Admin Defined Tables & Variation Tables
– Update to Material selection from experiment to include Name
Samples
– Inclusion of Reaction ID in Sample Update Modal
Plates
– New Properties Annotation Type
Inventory
– System Supplier List available in new Material Library (beta)
– Exponential notation update on Container Amount on Batch/Lots
Materials
– Bulk import of salts for compounds
– Bulk update of salts & solvates for materials
– 'dd-MM-yyyy' date format for bulk import
Integrations & APIs
– New API to recall Synergy Work Order
– New APIs to move locations to new parent locations
– New API for creating a material from a material table
– Download option for Notebook API Yaml Files

We also fixed several small bugs in this release. Details of the enhancements are described below.

Administrators should be aware that the stereochemical annotation of pseudochiral OR centers using the guided stereo tool will change to add an additional label which will interpreted as chemically significant. This change will occur in a future release and only apply to annotations made subsequent to the change, existing compounds will remain with the prior understanding until edited.

This content is anticipated for release on our Production E3 environments, and for Private Cloud customers on our deferred release schedule, in November 2025.

Further Details

Fundamentals

When a user updates the Layout for System Templates and Experiment-like objects, the audit trail captures previous and current versions for the layout changes including Rename Page, Add Page, Delete Page, & Reorder Page. This change only applies to content updated after the update.

Additionally, when an admin updates metadata within a User’s profile, the “Updated User” audit record within the Admin Audit Trail displays current and previous versions of the specific changes to the user’s metadata.

SAR & Decisioning

Inventa Analysis users can now filter SAR Groups data by Data Factory project to focus on the most relevant data.

Users can now include Details-level measurement types in the Combined Unsummarized Table within the the Integrated Summary App.

The Target Engagement Profiler now defaults to “continuous” x-axis when viewing Concentration vs. Time, within a convenient checkbox to switch to a categorical view.

Synergy

Sponsors often need to provide additional information related to a specific Design or Material (ExID) using Reference Table admin-defined fields. For example, a Sponsor may need to indicate which assays to run on specific compounds or the amount and minimum purity requested for each Design being synthesized. Sponsor users can now Bulk Fill values in Reference Tables using copy-paste from cells within the table or from an excel or csv file.

In addition, users can also Bulk Fill multiple cells in a column with the same value. After selecting a set of rows, users choose a column from the Bulk Fill menu and then enter or select a value. After pressing Bulk Fill, the same value is applied to the cells in all selected rows.

Salt information for a batch may be very important for a CRO to know when running an assay or analysis. Thus, Salt information can now be configured as Shareable to CRO in batch Reference Tables for Material libraries of type Compounds. When set to Shareable to CRO, a Sponsor can include the primary (first) Salt Name, MF, MW, and Coefficient in a batch Reference Table for a CRO Work Order.

When searching for Work Orders or Designs, it may be useful to search for those that recently changed Statuses. For example, which Work Orders were recently transitioned or which Designs were Proposed or Sent in the last week. Status Modified is a new properties on Work Orders and Designs available in Advanced Search and Smart Folder filters.

Finally, internal users and user groups now receive a notification (if configured) when a Design is assigned to them.

Chemistry

A new 'Analysis' panel in the ChemDraw editor now displays basic chemical properties for structures and biopolymers. These properties are context-sensitive, based on the selection on the canvas, and include information such as chemical name, molecular weight, molecular formula, and exact mass.

Specific properties from the Analysis Panel can be added directly to the ChemDraw canvas. Clicking the 'Add to Drawing' button at the bottom of the panel opens a window where properties can be selected and pasted onto the canvas.

Hydrogen bonded fragments in ChemDraw will now be recognized as a single structure with properties such as molecular weight, molecular formula and exact mass being calculated accordingly.

Admin Defined Tables & Variation Tables

Update to Material selection from experiment to include Name in Variation Table. Administrators will need to add the Material Name field and set it to be of type Variable Property. They will then be able to select the Name for the Variable Parameter and set the Material ID as the Internal Reference Column Name:

This allows the user when selecting material for the components in the Variation Table, to populate the Name (Chemical or otherwise) at the same time as the Material ID:

The user will see both columns fill in with data automatically:

Samples

To aid users in selecting the correct structure during the sample update process, we now include the Reaction ID in the sample update modal.

Plates

Users can now add a new Annotation layer type, Property. Annotation layers of type Property are collected in a properties tab on the plate and have a single value for every well in the plate.

Admins can add Property Annotation layers to plate templates as is currently done with other annotation layers. When end users fill in a value in a property, the value populates for every well in the plate table

Users can hide or edit the names of the property type annotation layers.

Inventory

Exponential notation update on Container Amount on Batch/Lots. Scientific notation will appear only after 5 digits (ex: mg in the screenshot)

Materials

For Materials libraries of type Compounds, Salts can now be included during Bulk Import. Salt Name and Coefficient can be matched to columns in an SD or CSV file. The Salt Name must match an existing system salt (Signals Configuration > System Settings > Salts and Solvates) and only one salt per compound batch is supported.

The ‘dd-MM-yyyy’ format (e.g. ’15-02-2019’) is now available as a Date Format option during bulk importing of materials.

Integrations & APIs

We have updated our Synergy API to support recalling of Work Orders.

PUT /synergy/workOrders/{workOrderId}/status now supports the “recall” action. A Work Order must be in the To-Do state for this action to succeed.

We have added new APIs to move a sub-location to a new parent location. This is an asynchronous API that follows our standard pattern of Begin Move Job, Check Status of Move and Download Report of Move. Only location that include the “movable” system property and have it enabled will be able to move to new parent locations.

We have also added a new API to register a new material from a material table. The table must be configured to allow for material registration in System Configuration. The row being registered as a new material must have all required data for the material to successfully register.

We have also added a method to download all the YAML files which back our Notebook Swagger page via Signals Configuration. This is to make it convenient to access these files for usage with SDK generation tools. They were tested with OpenAPI Generator.

Further Details

AI

Users with a Signals One license will now have access to the new Semantic Search. Semantic search is an AI-powered method of searching that focuses on understanding the meaning and context of a user's query, rather than just matching keywords. It leverages Natural Language Processing (NLP) and Machine Learning (ML) to interpret the user's intent and deliver more relevant search results.

To enable Semantic Search users just need to click the Sematic Search icon to enable semantic search.

Data Workflows & Analytics

The first rows of data assembled from multiple sources (instruments data, plates, external lookup tables,…) can now be previewed in the Data Assembly.

The Preview highlights the columns used for matching and the columns added to the instrument data. A column first added before being used for matching will have the column header highlighted as “Matched” and the content rows as “Added”. The Preview appears upon assembling the data when pressing the “Assemble” button.

Calculations can be applied when analyzing two instrument readouts in Vitro Analysis. Two instrument readouts can now be used (Read 1 and 2) and combined using a predefined calculation.

When user changes like exclusions or settings modification take place in the analytics steps, each step can be recalculated independently from the other steps using the new “Recalculate” button.

When the next step in the analytics is impacted, the recalculated button of the downstream step is enabled and the user notified that the steps are out of sync (e.g. normalization changes that impact curve fitting).

When potential problems are detected, warnings become visible in the user interface to help users identify early on the sources of problems.

In this example, the matching of two columns returns no rows, which is an indication of a wrong selection of columns to match.

SAR & Decisioning

Custom Entity data can now be published directly to Data Factory projects (beta version) from the Inventa Dashboard.

Inventa Sync now supports Data Factory projects (beta version). Map material libraries to projects using the new Data Factory Mapping section (accessible from the Material Management page), then activate sync on a per-project basis though the Project Activation and Status section.

Inventory

System Supplier List available in Material Library. Administrators can now add the System Supplier List to the Materials Library at both the asset level:

And the batch/lot level:

Multiple Fields can be associated with the System Supplier List and can be added to the Materials Table:

Users will see the fields in the Materials Table when they add them to an Experiment/ADO:

Bulk Import to a Materials Library supports the System Supplier List field type:

The mapping import screen as well as the example file supports the System Supplier List field:

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What's New

What's New

Further Details

Data Workflows & Analytics

SAR & Decisioning

Chemistry

Tables

Worksheets

Inventory

Materials

Tasks and Requests

Administration

Integrations & APIs

Beta Features

Fundamentals

Tables

Materials

What’s New

ChemDraw+

ChemDraw+

New context-sensitive ChemDraw floating toolbar

RXN file support in the ChemDraw editor

Turn on atom numbers for chemical objects

HELM editor now supports monomer structure searching

Highlight coloring is now available

Notebook descriptions are now viewable in the application

Import & Export options have expanded

What’s New

ChemDraw Desktop

ChemDraw Desktop

Properties Calculations

HELM Improvements

Python Support

What's New

Further Details

Fundamentals

AI

Data Workflows & Analytics

Synergy

Chemistry

Admin Defined Tables, Variation Tables and Hierarchical Tables

Materials

ELN Archive

Administration

Integrations & APIs

Further Details

SAR & Decisioning

Admin Defined Tables, Variation Tables and Hierarchical Tables

Materials

Administration

What’s New

ChemDraw+

ChemDraw+

Created by filter now available on the Dashboard

Periodic table available in ChemDraw editor

Creation of atom lists are now possible in the periodic table tool

Chemical objects can now be copied as 'MOLV3000 (Expanded)'

Monomers are now searchable and replaceable when editing biopolymers

'Copy As HELM (natural analog)' replaced by 'Copy as FASTA'

Object colors can now be changed

Ring Fill coloring is now available

Mass Fragmentation tool now available

Alignment tools now available

What's New

Further Details

Fundamentals

Data Workflows & Analytics

SAR & Decisioning

Synergy

Chemistry

Admin Defined Tables, Variation Tables and Hierarchical Tables

Inventory

Integrations & APIs

Further Details

Admin Defined Tables, Variation Tables and Hierarchical Tables

Worksheets

Administration

What's New

Further Details