Revvity Signals

What’s New

We’re delighted to introduce new enhancements that improve accuracy, performance, and flexibility in version 26.0 of ChemDraw Desktop. This release focuses on more efficient chemical property calculations, expanded HELM rendering capabilities, updated atomic standards, and extended Python support. We have also addressed several bugs to ensure a smoother experience.

ChemDraw Desktop

Chemistry Improvements
Advanced Biopolymer (HELM) Improvements
Extended Python Support

Chemdraw Desktop

Chemistry Improvements

A stereochemical warning is now shown when a stereo bond originates from a non-stereo atom, improving structural validation.

When viewing structures in 3D, selection highlighting is suppressed while dragging so that depth and perspective shading are easier to observe.

Chemical property calculations now run more efficiently, allowing you to continue drawing and editing seamlessly, even with large structures.

LogP calculations support up to 150 heavy atoms or 50 fluorine atoms, while other property calculations support up to 1,000 atoms.

Element atomic weights have been updated to IUPAC 2024 standards for Gadolinium, Lutetium, and Zirconium.

HELM Improvements

ChemDraw now supports hairpin structures in oligonucleotides. When hydrogen bonds are drawn between complementary bases within a single sequence, cleanup automatically forms the corresponding hairpin loop. Monomers within the hairpin can also be expanded and contracted. Pendant chemical and peptide attachments are also supported.

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Visual clarity for crosslinking between sequences has been enhanced, with bonds now vertically aligned whenever possible to minimize unnecessary wrapping between sequences.

ChemDraw now allows users to draw biopolymers with multiple complementary RNA strands for a single sense strand. When a set of hydrogen-bonded RNA sequences is created, ChemDraw detects the strands, and appropriately places each complement beneath the sense strand according to hydrogen bond positions on clean up. The sense backbone is stretched as needed to minimize overlap, enabling side-by-side display of complements with proper alignment.

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Selecting a routed bond between sequences now highlights the entire bond rather than only the center section.

Python Support

ChemScript now supports Python version 3.14, giving developers greater flexibility for integration and automation.

What’s New

This latest Signals release includes updates to ChemDraw+. Highlights include Drawing and Notebook properties, new filtering capabilities and expanded complex biopolymer support. This release also includes bug fixes.

The following improvements are available for users of Signals ChemDraw. Certain features may only be available with enablement by an administrator.

ChemDraw+

Drawing & Notebook Properties
New column filters for faster list view searching
Multi-strand and branched complex biopolymers now supported

ChemDraw+

Drawing & Notebook Properties

ChemDraw+ now includes a properties page for notebooks and drawings, making it easier to view and update details like name, description, created and modified information details in one place.

Image 1 from Signals ChemDraw What's New 26.4_May_2026.docx

Custom properties configured by an administrator can also be viewed and edited directly from the same page for Notebooks.

New column filters for faster list view searching

Image 2 from Signals ChemDraw What's New 26.4_May_2026.docx

New column filters in ChemDraw+ make it easier to find drawings and notebooks in Drawings, Notebooks, Notebook Details, and Favorites. Filter by name, creator, or last modified date using options like exact match, starts with, today, this week, last month, or a custom date range.

Image 3 from Signals ChemDraw What's New 26.4_May_2026.docx

Use multiple filters across one or more columns to narrow results faster. Active filters appear above the table and can be removed individually or cleared all at once.

Support for Multi-strand and Branched Biopolymers

ChemDraw Editor now supports cleanup for multi-strand and branched complex biopolymers, making these structures easier to display in a clear, aligned, and readable layout.

What's New

This latest Signals release includes updates to ChemDraw+, Signals Home Portal, and HELM Monomer Curation. Highlights include installer checksums in Signals Home Portal, structure search in HELM Monomer Curation, and accessibility improvements in ChemDraw+ that support WCAG 2.1 AA compliance. This release also includes bug fixes.

The following improvements are available for users of Signals ChemDraw. Certain features may only be available with enablement by an administrator.

Signals Home Portal

ChemDraw installer checksums are now available

ChemDraw+

Add/edit drawing descriptions from the breadcrumb
Pair multiple RNA/DNA strands to a single RNA/DNA sequence
Accessibility improvements towards WCAG 2.1 AA compliance

HELM Monomer Curation

Search for monomers by structure

Signals Home Portal

ChemDraw installer checksums are now available

SHA256 checksums are now available from the ‘ChemDraw Installers’ tile in the Signals portal so users and IT teams can verify ChemDraw installers before deployment.

ChemDraw+

Add/Edit drawing descriptions directly from the breadcrumb

Drawing descriptions can now be added or edited directly from the breadcrumb whenever needed.

Pair multiple RNA/DNA strands to a single RNA/DNA sequence

ChemDraw now allows users to draw biopolymers with multiple complementary RNA strands for a single sense strand. When a set of hydrogen-bonded RNA sequences is created, ChemDraw detects the sense strand, identifies each first-degree complementary strand, and automatically places each complement beneath the sense strand according to hydrogen bond positions. The sense backbone is stretched as needed to minimize overlap, enabling side-by-side display of complements with proper alignment.

Accessibility improvements towards WCAG 2.1 AA compliance

ChemDraw+ now includes accessibility improvements that support WCAG 2.1 AA compliance and make the experience easier to use with keyboards, screen readers, and zoomed displays. The following improvements have been made:

– Improved color contrast, focus states, and navigation cues
– Expanded keyboard support across navigation, toolbars, and popovers
– Enhanced screen reader support with better labels, headings, link text, and dialog names
– Improved form accessibility, error messaging, and autocomplete behavior
– Updated zoom, reflow, session timeout, and login page accessibility

HELM Monomer Curation

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New capabilities have been added to the HELM Monomer Curation application for filtering and searching monomers based on chemical structures. Available as a button next to the text search field in the HELM Libraries list view, the ‘Structure…’ button opens a structure editor.

Image 5 from Signals ChemDraw What's New 26.3_April 2026.docx

After drawing a structure, users can select from substructure, similarity, full, and exact search options. Selecting ‘Search’ will then initiate the search filter.

After completing a structure search, the ‘Structure…’ button transforms into an ‘Edit’ button. Selecting this button allows for previewing the structure, making changes to it, or removing it from the search filter. Structure searches can be combined with text-based searches to refine results even further.

What’s New

The latest release of Signals brings improvements to the ChemDraw+ application. This release enhances the drawing and analysis experience with predicted pKa calculations now available in the ChemDraw analysis panel and expanded capabilities of the auto-pair tool for complementary strands and hairpins. Finally, we have also fixed a small number of bugs.

The following improvements are available for users of Signals ChemDraw. Certain features may only be available with enablement by an administrator.

ChemDraw+

Edit notebook descriptions from the breadcrumb
Calculate predicted pKa in the Analysis panel
Generate hairpins with pendant linkers or peptides
Preserve user-defined hydrogen bonds when auto-pairing
Auto-pair selected oligonucleotide fragments

ChemDraw+

Edit notebook descriptions directly from the breadcrumb

Notebook descriptions can now be edited directly from the breadcrumb whenever needed.

Calculate predicted pKa in the Analysis panel

Predicted pKa is now available as a calculated property in the ChemDraw Analysis panel. The calculation uses the current selection, supports structures with fewer than 100 heavy atoms, and returns the predicted pKa value, type (acid or base), and atom label. When atom numbering is enabled in the drawing, the corresponding atom number is also shown in the Analysis panel.

Generate hairpins with pendant linkers or peptides

Hairpins can now be generated from oligonucleotide sequences that include pendant chemical linkers or peptides by using the auto-pair tool to automatically find base complementarity and place hydrogen bonds to form the hairpin structure.

Preserve user-defined hydrogen bonds when auto-pairing

When there are multiple ways to create a complementary strand or hairpin, the auto-pair tool can now be used after placing one or more hydrogen bonds between nucleobases. ChemDraw then uses those existing hydrogen bonds as a guide, preserves them, finds the best remaining base complementarity, and adds the hydrogen bonds needed to complete the complementary strand or hairpin.

Auto-pair selected oligonucleotide fragments

The auto-pair tool now supports partial selections of oligonucleotide strands, pairing compatible nucleobases within the selected regions and adding the corresponding hydrogen bonds between them.

What’s New

The latest release of Signals brings improvements to the ChemDraw+ application. This release enhances the drawing and analysis experience with LogP calculation in the ChemDraw analysis panel, new support for generating hairpins, and streamlined notebook workflows in ChemDraw+. Additionally, support has been added for SD/RD files in the application. Finally, we have also fixed a small number of bugs.

The following improvements are available for users of Signals ChemDraw. Certain features may only be available with enablement by an administrator.

ChemDraw+

Add drawing to a notebook from its detail page
Copy drawings into a notebook
Rename notebooks directly from the breadcrumb
Import now supports SD and RD files
Calculate LogP in the Analysis panel
Generate hairpins from a single oligonucleotide
Drag-and-drop SD/RD files onto the ChemDraw canvas

ChemDraw+

Add drawing to a notebook from its detail page

Create and add a new drawing to a Notebook directly from the Notebook detail page in ChemDraw+. The drawing is created using the most recently used style sheet and given an automatic name, which can be updated from the breadcrumb.

Copy drawings into a notebook

Drawings can now be copied into a Notebook in ChemDraw+ from the drawing view and added to any selected Notebook in the application

Rename notebooks directly from the breadcrumb

Notebooks can be renamed directly from the breadcrumb whenever needed. Renaming is available for any Notebook that is not automatically named when created.

Import now supports SD and RD files

ChemDraw+ now supports importing SD and RD files. When these files are brought into the application, they are automatically converted to CDXML format, enabling full editing capabilities within the application.

Calculate LogP in the Analysis panel

LogP is now available as a calculated property in the analysis panel of the ChemDraw editor. The calculation is based on the current selection and supports structures containing fewer than 1,000 atoms or 150 heavy atoms.

Generate hairpins from a single oligonucleotide

The ‘auto-pair’ tool in the ChemDraw editor can now generate hairpins from a single oligonucleotide sequence. It identifies the region of maximum complementarity within the strand, places hydrogen bonds between complementary nucleobases, and forms a hairpin loop from the remaining unpaired nucleobases.

Drag-and-drop SD/RD files onto the ChemDraw canvas

SD and RD files can now be dragged and dropped onto a ChemDraw canvas and converted automatically to cdxml for continued editing.

What’s New

The latest release of Signals brings improvements to the ChemDraw+ application. This release brings enhancements to the drawing experience including the introduction of a new context sensitive toolbar in the drawing editor, monomer searching in the HELM editor, and highlight coloring options. Additionally, import/export support has been expanded. Finally, we have also fixed a small number of bugs.

The following improvements are available for users of Signals ChemDraw. Certain features may only be available with enablement by an administrator.

ChemDraw+

New context-sensitive ChemDraw floating toolbar
RXN file support in the ChemDraw editor
Turn on atom numbers for chemical objects
HELM editor now supports monomer structure searching
Highlight coloring now available
Notebook descriptions are now viewable in the application
Import & Export options have expanded

ChemDraw+

New context-sensitive ChemDraw floating toolbar

A context-sensitive floating toolbar is now available in the ChemDraw editor. When objects are selected on the ChemDraw canvas, a toolbar appears above the selection, displaying commonly used tools based on the selected object. As the pointer moves away from the toolbar, it automatically hides to minimize disruption to the editing process.

RXN file support in the ChemDraw editor

RXN files can now be dragged and dropped onto a ChemDraw canvas and converted automatically to cdxml for continued editing.

Turn on atom numbers for chemical objects

Atom numbers in ChemDraw can now be enabled for a selected object by selecting 'Show atom numbers' in the Atom section of the Properties panel.

HELM editor now supports monomer structure searching

The HELM editor now supports structure-based monomer search alongside text search, using a new Structure button and preview panel in the Peptide, RNA/DNA, and Chem/Blob tabs. Structures can be pasted from common formats (cdxml, cdx, SMILES, molV2000/3000, InChI) and searched as substructure, similar, full, exact, or full including tautomers, with results returned directly in the monomer panel. Structure and text filters can be combined to refine monomer results within the active library.

Highlight coloring is now available

You can now highlight atoms, labels, and bonds to draw attention to specific parts of a chemical structure to facilitate clear communication and focused presentations. This feature is available in the Colors section of the Properties panel or as a tool in the right-hand context toolbar. Choose a highlight color from the predefined palette or enter an exact hex code to create publication-ready chemical drawings.

Notebook descriptions are now viewable in the application

Notebook descriptions are now displayed in ChemDraw+ in both the Notebook List and Notebook Details views.

Import & Export options have expanded

ChemDraw+ now supports importing MOL and RXN files. When these files are brought into the application, they are automatically converted to CDXML format, enabling full editing capabilities within ChemDraw+. Additionally, export options in ChemDraw+ have expanded to include expanded MOL and SD files (V3000) as well as RXN files.

What’s New

We’re excited to introduce new enhancements that improve accuracy, performance, and flexibility across Signals ChemDraw. This release focuses on property calculations, HELM handling, and extended Python support for ChemScript. Finally, we have also fixed a small number of bugs.

ChemDraw Desktop

Properties Calculations
HELM Improvements
Support of Python 3.13.x, 3.10.x & 3.9.x

ChemDraw Desktop

Properties Calculations

LogP and Molar Refractivity (MR) calculations are now powered by RDKit, delivering more accurate and consistent results in the Chemical Properties window.

Property calculations have also been optimized for efficiency: when editing large structures with the Chemical Properties window open, updates are now queued to minimize lag and ensure a smoother editing experience.

HELM Improvements

Biopolymer cleanup has been significantly. Sequences appended to complementary strands are now properly arranged, and pendant sequences are tidied for clarity.

Leading and trailing phosphates, when omitted from a sequence, are matched with natural phosphates in the complementary strand.

Sequence selection behavior has also been improved: double-click and triple-click actions now provide intuitive selection of monomers, sequences, and groups.

Finally, the menu option Edit > Copy As HELM (Natural Analog) has been renamed to Edit > Copy As FASTA for clarity.

Python Support

ChemScript now supports Python versions 3.13.x, 3.10.x, and 3.9.x, giving developers greater flexibility for integration and automation.

What’s New

The latest release of Signals brings improvements to the ChemDraw+ application. This release brings enhancements to the drawing experience including the introduction of a new periodic table tool, object and ring fill coloring options, as well as tools for mass fragmentation and alignment. Additionally, improvements to the biopolymer editing experience with the introduction of a find and replace capability within the HELM editor. Finally, we have also fixed a small number of bugs.

The following improvements are available for users of Signals ChemDraw. Certain features may only be available with enablement by an administrator.

ChemDraw+

Created by filter now available on the Dashboard
Periodic table available in ChemDraw editor
Creation of atom lists are now possible in the periodic table tool
Chemical objects can now be copied as 'MOLV3000 (Expanded)'
'Copy As HELM (natural analog)' updated to 'Copy as FASTA'
Chemical Object colors can now be changed
Ring Fill coloring can now be applied
Mass Fragmentation tool now available
Alignment tools now available
Monomers can now be searched for, found and replaced when editing biopolymers

ChemDraw+

Created by filter now available on the Dashboard

Periodic table available in ChemDraw editor

Use the new ‘Created by’ filter on the ChemDraw+ Dashboard to control what appears in Recent Drawings. Select ‘Created by me’ to see only recently modified drawings that you created (not ones shared by other users). Select ‘Created by anyone’ to see all recently modified drawings you can access in your account.

The periodic table tool, now available in the ChemDraw toolbar, enables selection of any element to add to the canvas. When an object is selected, choosing an element from the periodic table replaces it; otherwise, any atom or blank space on the canvas can be replaced with the selected element.

Creation of atom lists are now possible in the periodic table tool

Creation of atom lists for the generation of generic structures is now also possible with the new periodic table tool. Upon opening the tool in ChemDraw, users can select List which will allow the selection of multiple elements. Once the list is generated, selecting 'Apply' will allow the user to place the atom list on the canvas in brackets.

Chemical objects can now be copied as 'MOLV3000 (Expanded)'

Chemical objects on the ChemDraw canvas can now be copied as an expanded V3000 molfile. When using 'Copy As MOLV3000 (Expanded)', a fully expanded version of the chemical object will be copied, including the expansion of all nicknames, labels, and HELM biopolymers.

Monomers are now searchable and replaceable when editing biopolymers

The HELM Editor in ChemDraw now supports finding and selecting specific monomers on the canvas for replacement. One or more monomers can be identified and selected simultaneously using the ‘Find….’ dialog in the HELM editor, and all instances found will be selected for replacement. Selecting a new monomer from the HELM editor replaces all selected monomers on the canvas with the chosen selection. This bulk find and replace capability streamlines large-scale modifications of sequences, enabling rapid transformation of a natural sequence from a FASTA string into a highly complex sequence with custom modifications.

'Copy As HELM (natural analog)' replaced by 'Copy as FASTA'

The Copy As options for HELM biopolymers in ChemDraw have been updated. The 'Copy as HELM (natural analog)' function has been replaced by 'Copy as FASTA.' This change more accurately reflects that a FASTA sequence containing all natural analogs will be copied when this option is selected, with no change in the underlying behavior.

Object colors can now be changed

Object colors can be now adjusted directly from the Colors section in the Properties panel. Choose a hue from the color picker’s pre-defined palette or enter an exact hex code for precise control when creating publication-ready chemical drawings.

Ring Fill coloring is now available

Ring fill color can be now be applied to chemical rings enabling clearer communication of ideas and concepts by directing the focus of a reader or an audience to a given part of a chemical structure. Available in the Colors section of the Properties panel, users can choose a fill color from the color picker’s pre-defined palette or enter an exact hex code to fill ring systems and create publication-ready chemical drawings.

Mass Fragmentation tool now available

A new fragmentation tool is available in the left hand general drawing toolbar in the ChemDraw editor. When used, the mass fragmentation tool mimics the Mass Spec fragmentation to generate fragment structures with calculated molecular formulas and masses.

Alignment tools now available

Structure and reaction alignment is now available in the ChemDraw editor. With objects selected on the canvas, use the right-hand context toolbar to center, align horizontally or vertically, and distribute evenly to produce clean, consistent, publication-ready figures.

What’s New

The latest release of Signals brings improvements to the ChemDraw+ application. This release brings enhancements to the structure to name capabilities in the application. We also have new improvements to increase the efficiency of drawing biopolymers in ChemDraw. Finally, we have also fixed a small number of bugs. The following improvements are available for users of Signals ChemDraw. Certain features may only be available with enablement by an administrator.

The following improvements are available for users of Signals ChemDraw.

ChemDraw+

Name to Structure capability expanded to use ChemACX
Drawing of individual RNA or DNA monomers when editing biopolymers
Selection and replacement of multiple monomers at once in biopolymers

ChemDraw+

Name to Structure capability expanded to use ChemACX

Converting names to structures in ChemDraw+ now utilizes the ChemACX, which is a unified chemical database containing 10s of millions of substances. The use of ChemACX now allows the conversion of synonyms, trade names or common names of the substances within the database to a structure.

Drawing of individual RNA or DNA monomers when editing biopolymers

Support for drawing individual RNA/DNA monomers has been added to the HELM editor. When editing in the RNA/DNA tab of the HELM Editor, there is a new "none' option available in the dropdown menu for secondary monomers. When 'None' is selected, a monomer of that type will not be drawn when the primary monomer is added to the ChemDraw canvas. Additionally, if the user wishes to draw using only the primary monomer (ribose, base or phosphate), a modifier key is available. Selecting alt/option + the monomer will only add the primary monomer to the canvas.

Selection and replacement of multiple monomers at once in biopolymers

Bulk selection of monomers while in HELM edit mode is now possible by using the 'Shift' key and selecting multiple monomers on the canvas. Once selected, these monomers can be replaced simply by selecting a new monomer in the HELM editor.

What’s New

The latest release of Signals brings improvements to the ChemDraw+ application. Basic chemical properties of structures and biopolymers can now be selected for addition to a drawing from the Analysis panel. Additionally, hydrogen bonded fragments are now recognized as a single structure. This release also includes several bug fixes, further improving the overall user experience.

The following improvements are available for users of Signals ChemDraw.

ChemDraw+

Enhanced property selection control when adding to drawings
Hydrogen-bonded fragments are treated as a single structure

ChemDraw+

Add selected chemical properties to the ChemDraw canvas

The Analysis panel now offers improved flexibility when adding chemical properties to drawings. Users can now choose which properties to add to their drawing when using the 'Add to Drawing' button located at the bottom of the Analysis panel. Selecting this button now opens a window where properties can be selected to be pasted onto the canvas.

Hydrogen-bonded fragments are treated as a single structure

Hydrogen bonded fragments in ChemDraw will now be recognized as a single structure with properties such as molecular weight, molecular formula and exact mass being calculated accordingly.

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What's New